TNR18_HUMAN - dbPTM
TNR18_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TNR18_HUMAN
UniProt AC Q9Y5U5
Protein Name Tumor necrosis factor receptor superfamily member 18
Gene Name TNFRSF18
Organism Homo sapiens (Human).
Sequence Length 241
Subcellular Localization Isoform 1: Cell membrane
Single-pass type I membrane protein.
Isoform 2: Secreted.
Protein Description Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway..
Protein Sequence MAQHGAMGAFRALCGLALLCALSLGQRPTGGPGCGPGRLLLGTGTDARCCRVHTTRCCRDYPGEECCSEWDCMCVQPEFHCGDPCCTTCRHHPCPPGQGVQSQGKFSFGFQCIDCASGTFSGGHEGHCKPWTDCTQFGFLTVFPGNKTHNAVCVPGSPPAEPLGWLTVVLLAVAACVLLLTSAQLGLHIWQLRSQCMWPRETQLLLEVPPSTEDARSCQFPEEERGERSAEEKGRLGDLWV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
146N-linked_GlycosylationFLTVFPGNKTHNAVC
EEEEECCCCCCCEEE
46.41UniProtKB CARBOHYD
202PhosphorylationQCMWPRETQLLLEVP
HCCCCCCCEEEEECC
26.2930624053
211PhosphorylationLLLEVPPSTEDARSC
EEEECCCCCCCHHHC
38.0623312004
212PhosphorylationLLEVPPSTEDARSCQ
EEECCCCCCCHHHCC
43.5928985074
217PhosphorylationPSTEDARSCQFPEEE
CCCCCHHHCCCCHHH
17.6228985074

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TNR18_HUMAN !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TNR18_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TNR18_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TRAF1_HUMANTRAF1physical
10037686
TRAF3_HUMANTRAF3physical
10037686
TRAF2_HUMANTRAF2physical
10037686
TNR18_HUMANTNFRSF18physical
10074428
TRAF1_HUMANTRAF1physical
15944293
TRAF2_HUMANTRAF2physical
15944293
TRAF3_HUMANTRAF3physical
15944293

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TNR18_HUMAN

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Related Literatures of Post-Translational Modification

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