| UniProt ID | TNR18_HUMAN | |
|---|---|---|
| UniProt AC | Q9Y5U5 | |
| Protein Name | Tumor necrosis factor receptor superfamily member 18 | |
| Gene Name | TNFRSF18 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 241 | |
| Subcellular Localization |
Isoform 1: Cell membrane Single-pass type I membrane protein. Isoform 2: Secreted. |
|
| Protein Description | Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway.. | |
| Protein Sequence | MAQHGAMGAFRALCGLALLCALSLGQRPTGGPGCGPGRLLLGTGTDARCCRVHTTRCCRDYPGEECCSEWDCMCVQPEFHCGDPCCTTCRHHPCPPGQGVQSQGKFSFGFQCIDCASGTFSGGHEGHCKPWTDCTQFGFLTVFPGNKTHNAVCVPGSPPAEPLGWLTVVLLAVAACVLLLTSAQLGLHIWQLRSQCMWPRETQLLLEVPPSTEDARSCQFPEEERGERSAEEKGRLGDLWV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 146 | N-linked_Glycosylation | FLTVFPGNKTHNAVC EEEEECCCCCCCEEE | 46.41 | UniProtKB CARBOHYD | |
| 202 | Phosphorylation | QCMWPRETQLLLEVP HCCCCCCCEEEEECC | 26.29 | 30624053 | |
| 211 | Phosphorylation | LLLEVPPSTEDARSC EEEECCCCCCCHHHC | 38.06 | 23312004 | |
| 212 | Phosphorylation | LLEVPPSTEDARSCQ EEECCCCCCCHHHCC | 43.59 | 28985074 | |
| 217 | Phosphorylation | PSTEDARSCQFPEEE CCCCCHHHCCCCHHH | 17.62 | 28985074 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TNR18_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TNR18_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TNR18_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| TRAF1_HUMAN | TRAF1 | physical | 10037686 | |
| TRAF3_HUMAN | TRAF3 | physical | 10037686 | |
| TRAF2_HUMAN | TRAF2 | physical | 10037686 | |
| TNR18_HUMAN | TNFRSF18 | physical | 10074428 | |
| TRAF1_HUMAN | TRAF1 | physical | 15944293 | |
| TRAF2_HUMAN | TRAF2 | physical | 15944293 | |
| TRAF3_HUMAN | TRAF3 | physical | 15944293 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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