MT21A_HUMAN - dbPTM
MT21A_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MT21A_HUMAN
UniProt AC Q8WXB1
Protein Name Protein N-lysine methyltransferase METTL21A
Gene Name METTL21A
Organism Homo sapiens (Human).
Sequence Length 218
Subcellular Localization Cytoplasm .
Protein Description Protein-lysine methyltransferase that selectively trimethylates residues in heat shock protein 70 (HSP70) family members. Contributes to the in vivo trimethylation of Lys residues in HSPA1 and HSPA8. In vitro methylates 'Lys-561' in HSPA1, 'Lys-564' in HSPA2, 'Lys-585' in HSPA5, 'Lys-563' in HSPA6 and 'Lys-561' in HSPA8..
Protein Sequence MALVPYEETTEFGLQKFHKPLATFSFANHTIQIRQDWRHLGVAAVVWDAAIVLSTYLEMGAVELRGRSAVELGAGTGLVGIVAALLGAHVTITDRKVALEFLKSNVQANLPPHIQTKTVVKELTWGQNLGSFSPGEFDLILGADIIYLEETFTDLLQTLEHLCSNHSVILLACRIRYERDNNFLAMLERQFTVRKVHYDPEKDVHIYEAQKRNQKEDL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
68 (in isoform 2)Phosphorylation-39.2228634298
76 (in isoform 2)Phosphorylation-27.1528634298
103AcetylationKVALEFLKSNVQANL
HHHHHHHHHHHHHCC		45.3530588665
104PhosphorylationVALEFLKSNVQANLP
HHHHHHHHHHHHCCC		44.3630619164
192PhosphorylationAMLERQFTVRKVHYD
HHHEEEEEEEEEECC		15.8625690035
198PhosphorylationFTVRKVHYDPEKDVH
EEEEEEECCCCCCCC		35.8630576142
202UbiquitinationKVHYDPEKDVHIYEA
EEECCCCCCCCHHHH		71.13-
207PhosphorylationPEKDVHIYEAQKRNQ
CCCCCCHHHHHHHHH		7.1330576142
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MT21A_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MT21A_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MT21A_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
GRDN_HUMANCCDC88Aphysical
23349634
DYHC1_HUMANDYNC1H1physical
23349634
HS71L_HUMANHSPA1Lphysical
23349634
HSP72_HUMANHSPA2physical
23349634
HSP74_HUMANHSPA4physical
23349634
HS74L_HUMANHSPA4Lphysical
23349634
GRP78_HUMANHSPA5physical
23349634
HSP7C_HUMANHSPA8physical
23349634
GRP75_HUMANHSPA9physical
23349634
HPBP1_HUMANHSPBP1physical
23349634
HS105_HUMANHSPH1physical
23349634
MT21D_HUMANVCPKMTphysical
23349634
NCALD_HUMANNCALDphysical
23349634
HSP7C_HUMANHSPA8physical
26186194
HSP74_HUMANHSPA4physical
26186194
ZBED8_HUMANZBED8physical
21516116
HSP7C_HUMANHSPA8physical
28514442
HPBP1_HUMANHSPBP1physical
28514442
BAG3_HUMANBAG3physical
28514442
HSP74_HUMANHSPA4physical
28514442
HSP71_YEASTSSA1physical
26115316
HSP73_YEASTSSA3physical
26115316
HSP7C_HUMANHSPA8physical
26115316
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MT21A_HUMAN

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Related Literatures of Post-Translational Modification

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