CLD1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CLD1_HUMAN
• UniProt AC: O95832
• Protein Name: Claudin-1
• Gene Name: CLDN1
• Organism: Homo sapiens (Human).
• Sequence Length: 211
• Subcellular Localization: Cell junction, tight junction . Cell membrane ; Multi-pass membrane protein . Basolateral cell membrane . Associates with CD81 and the CLDN1-CD81 complex localizes to the basolateral cell membrane.
• Protein Description: Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions. [PubMed: 23407391; (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes]
• Protein Sequence: MANAGLQLLGFILAFLGWIGAIVSTALPQWRIYSYAGDNIVTAQAMYEGLWMSCVSQSTGQIQCKVFDSLLNLSSTLQATRALMVVGILLGVIAIFVATVGMKCMKCLEDDEVQKMRMAVIGGAIFLLAGLAILVATAWYGNRIVQEFYDPMTPVNARYEFGQALFTGWAAASLCLLGGALLCCSCPRKTTSYPTPRPYPKPAPSSGKDYV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
47	Phosphorylation	IVTAQAMYEGLWMSC CEEHHHHHCHHHHHH	15.17	23663014
53	Phosphorylation	MYEGLWMSCVSQSTG HHCHHHHHHHCCCCC	10.37	23663014
56	Phosphorylation	GLWMSCVSQSTGQIQ HHHHHHHCCCCCCEE	23.81	23663014
58	Phosphorylation	WMSCVSQSTGQIQCK HHHHHCCCCCCEEHH	27.31	23663014
59	Phosphorylation	MSCVSQSTGQIQCKV HHHHCCCCCCEEHHH	26.01	23663014
115	Ubiquitination	LEDDEVQKMRMAVIG CCCHHHHHHHHHHHH	33.38	-
153	Phosphorylation	QEFYDPMTPVNARYE HHHCCCCCCCCCCHH	29.49	-
189	Ubiquitination	LCCSCPRKTTSYPTP HHHCCCCCCCCCCCC	41.10	-
190	Phosphorylation	CCSCPRKTTSYPTPR HHCCCCCCCCCCCCC	23.43	23312004
191	Phosphorylation	CSCPRKTTSYPTPRP HCCCCCCCCCCCCCC	29.33	23312004
191	O-linked_Glycosylation	CSCPRKTTSYPTPRP HCCCCCCCCCCCCCC	29.33	56220399
192	Phosphorylation	SCPRKTTSYPTPRPY CCCCCCCCCCCCCCC	34.05	28102081
192	O-linked_Glycosylation	SCPRKTTSYPTPRPY CCCCCCCCCCCCCCC	34.05	54344803
193	Phosphorylation	CPRKTTSYPTPRPYP CCCCCCCCCCCCCCC	14.72	28102081
195	Phosphorylation	RKTTSYPTPRPYPKP CCCCCCCCCCCCCCC	24.56	23312004
199	Phosphorylation	SYPTPRPYPKPAPSS CCCCCCCCCCCCCCC	25.76	29759185
201	Ubiquitination	PTPRPYPKPAPSSGK CCCCCCCCCCCCCCC	48.22	-
205	O-linked_Glycosylation	PYPKPAPSSGKDYV- CCCCCCCCCCCCCC-	54.55	94959
205	Phosphorylation	PYPKPAPSSGKDYV- CCCCCCCCCCCCCC-	54.55	25348954
206	O-linked_Glycosylation	YPKPAPSSGKDYV-- CCCCCCCCCCCCC--	49.13	63995
206	Phosphorylation	YPKPAPSSGKDYV-- CCCCCCCCCCCCC--	49.13	25348954
208	Ubiquitination	KPAPSSGKDYV---- CCCCCCCCCCC----	48.08	-
210	Phosphorylation	APSSGKDYV------ CCCCCCCCC------	16.14	21082442

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CLD1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CLD1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CLD1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CLD3_HUMAN	CLDN3	physical	12909588
INADL_HUMAN	INADL	physical	12021270
ZO2_HUMAN	TJP2	physical	10601346
ZO1_HUMAN	TJP1	physical	10601346
ZO3_HUMAN	TJP3	physical	10601346
DRG1_HUMAN	DRG1	physical	21988832

Drug and Disease Associations

• Kegg Disease
• H00742: Neonatal ichthyosis-sclerosing cholangitis (NISCH) syndrome; Ichthyosis, leukocyte vacuoles, alopeci
• OMIM Disease
• 607626: Ichthyosis-sclerosing cholangitis neonatal syndrome (NISCH)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.