CLD3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CLD3_HUMAN
• UniProt AC: O15551
• Protein Name: Claudin-3
• Gene Name: CLDN3
• Organism: Homo sapiens (Human).
• Sequence Length: 220
• Subcellular Localization: Cell junction, tight junction . Cell membrane ; Multi-pass membrane protein .
• Protein Description: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity..
• Protein Sequence: MSMGLEITGTALAVLGWLGTIVCCALPMWRVSAFIGSNIITSQNIWEGLWMNCVVQSTGQMQCKVYDSLLALPQDLQAARALIVVAILLAAFGLLVALVGAQCTNCVQDDTAKAKITIVAGVLFLLAALLTLVPVSWSANTIIRDFYNPVVPEAQKREMGAGLYVGWAAAALQLLGGALLCCSCPPREKKYTATKVVYSAPRSTGPGASLGTGYDRKDYV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
103	S-palmitoylation	VALVGAQCTNCVQDD HHHHCCCCCCCCCCC	2.68	29097667
106	S-palmitoylation	VGAQCTNCVQDDTAK HCCCCCCCCCCCCHH	1.24	29097667
182	S-palmitoylation	LGGALLCCSCPPREK HCCHHHHCCCCCCCC	4.78	29097667
184	S-palmitoylation	GALLCCSCPPREKKY CHHHHCCCCCCCCCC	3.16	29097667
191	Phosphorylation	CPPREKKYTATKVVY CCCCCCCCEEEEEEE	16.81	26657352
192	Phosphorylation	PPREKKYTATKVVYS CCCCCCCEEEEEEEC	36.41	26657352
194	Phosphorylation	REKKYTATKVVYSAP CCCCCEEEEEEECCC	19.30	28857561
195	Ubiquitination	EKKYTATKVVYSAPR CCCCEEEEEEECCCC	27.52	-
198	Phosphorylation	YTATKVVYSAPRSTG CEEEEEEECCCCCCC	11.34	21945579
199	Phosphorylation	TATKVVYSAPRSTGP EEEEEEECCCCCCCC	21.86	21945579
203	Phosphorylation	VVYSAPRSTGPGASL EEECCCCCCCCCCCC	36.34	21945579
204	Phosphorylation	VYSAPRSTGPGASLG EECCCCCCCCCCCCC	48.99	21945579
209	Phosphorylation	RSTGPGASLGTGYDR CCCCCCCCCCCCCCC	32.99	21945579
212	Phosphorylation	GPGASLGTGYDRKDY CCCCCCCCCCCCCCC	37.55	21945579
214	Phosphorylation	GASLGTGYDRKDYV- CCCCCCCCCCCCCC-	16.65	21945579
219	Phosphorylation	TGYDRKDYV------ CCCCCCCCC------	15.87	27259358

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
192	T	Phosphorylation	Kinase	PRKACA	P17612	GPS
192	T	Phosphorylation	Kinase	PKA-FAMILY	-	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CLD3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CLD3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CLD1_HUMAN	CLDN1	physical	12909588
CLD5_HUMAN	CLDN5	physical	12909588
ZO1_HUMAN	TJP1	physical	10601346
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer.";
Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.;
Cell 131:1190-1203(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-214 AND TYR-219, ANDMASS SPECTROMETRY.
PubMed: 18083107