CLD5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CLD5_HUMAN
• UniProt AC: O00501
• Protein Name: Claudin-5
• Gene Name: CLDN5
• Organism: Homo sapiens (Human).
• Sequence Length: 218
• Subcellular Localization: Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
• Protein Description: Plays a major role in tight junction-specific obliteration of the intercellular space..
• Protein Sequence: MGSAALEILGLVLCLVGWGGLILACGLPMWQVTAFLDHNIVTAQTTWKGLWMSCVVQSTGHMQCKVYDSVLALSTEVQAARALTVSAVLLAFVALFVTLAGAQCTTCVAPGPAKARVALTGGVLYLFCGLLALVPLCWFANIVVREFYDPSVPVSQKYELGAALYIGWAATALLMVGGCLLCCGAWVCTGRPDLSFPVKYSAPRRPTATGDYDKKNYV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
86	Phosphorylation	AARALTVSAVLLAFV HHHHHHHHHHHHHHH	13.87	-
148	Phosphorylation	NIVVREFYDPSVPVS HHHHHHHCCCCCCCC	23.38	22671590
155	Phosphorylation	YDPSVPVSQKYELGA CCCCCCCCCCCCCCC	18.19	22461510
207	Phosphorylation	YSAPRRPTATGDYDK CCCCCCCCCCCCCCC	34.73	21082442
209	Phosphorylation	APRRPTATGDYDKKN CCCCCCCCCCCCCCC	32.82	23403867
212	Phosphorylation	RPTATGDYDKKNYV- CCCCCCCCCCCCCC-	30.89	21253578
217	Phosphorylation	GDYDKKNYV------ CCCCCCCCC------	19.20	21253578
233	Phosphorylation	---------------------- ----------------------		-
240	Phosphorylation	----------------------------- -----------------------------		-
292	Phosphorylation	--------------------------------------------------------------------------------- ---------------------------------------------------------------------------------		-
297	Phosphorylation	-------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------		18083107
302	Phosphorylation	------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------		18083107

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CLD5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CLD5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CLD5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CLD3_HUMAN	CLDN3	physical	12909588
ZO1_HUMAN	TJP1	physical	10601346

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer.";
Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.;
Cell 131:1190-1203(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-212 AND TYR-217, ANDMASS SPECTROMETRY.
PubMed: 18083107