SSR3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SSR3_HUMAN
• UniProt AC: P32745
• Protein Name: Somatostatin receptor type 3
• Gene Name: SSTR3
• Organism: Homo sapiens (Human).
• Sequence Length: 418
• Subcellular Localization: Cell membrane; Multi-pass membrane protein. Internalized into endoplasmic vesicles upon somatostatin-stimulation..
• Protein Description: Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase..
• Protein Sequence: MDMLHPSSVSTTSEPENASSAWPPDATLGNVSAGPSPAGLAVSGVLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLVMAVDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPEPAAAWRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVWAPSCQRRRRSERRVTRMVVAVVALFVLCWMPFYVLNIVNVVCPLPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGFRRVLLRPSRRVRSQEPTVGPPEKTEEEDEEEEDGEESREGGKGKEMNGRVSQITQPGTSGQERPPSRVASKEQQLLPQEASTGEKSSTMRISYL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MDMLHPSSVSTTSE -CCCCCCCCCCCCCC	32.40	23836654
8	Phosphorylation	MDMLHPSSVSTTSEP CCCCCCCCCCCCCCC	25.25	23836654
10	Phosphorylation	MLHPSSVSTTSEPEN CCCCCCCCCCCCCCC	28.10	23836654
11	Phosphorylation	LHPSSVSTTSEPENA CCCCCCCCCCCCCCC	31.99	23836654
12	Phosphorylation	HPSSVSTTSEPENAS CCCCCCCCCCCCCCC	24.48	23836654
13	Phosphorylation	PSSVSTTSEPENASS CCCCCCCCCCCCCCC	51.77	23836654
17	N-linked_Glycosylation	STTSEPENASSAWPP CCCCCCCCCCCCCCC	56.70	UniProtKB CARBOHYD
30	N-linked_Glycosylation	PPDATLGNVSAGPSP CCCCCCCCCCCCCCH	27.90	UniProtKB CARBOHYD
71	Methylation	LVIYVVLRHTASPSV HHHEEEECCCCCCCC	17.32	30761223
142	Phosphorylation	TVMSVDRYLAVVHPT EECCCCEEEEECCCC	8.44	24114839
162	Phosphorylation	RTAPVARTVSAAVWV CCCCCHHHHHHHHHH	14.74	22210691
164	Phosphorylation	APVARTVSAAVWVAS CCCHHHHHHHHHHHH	15.19	22210691
171	Phosphorylation	SAAVWVASAVVVLPV HHHHHHHHHHHEEEE	16.39	22210691
182	Phosphorylation	VLPVVVFSGVPRGMS EEEEEEECCCCCCCC	27.54	22210691
303	Phosphorylation	FLVVALPYANSCANP HHHHHHHHCCCCCCH	21.18	-
332	Phosphorylation	RRVLLRPSRRVRSQE HHHHCCCCCCCCCCC	26.70	9295322
337	Phosphorylation	RPSRRVRSQEPTVGP CCCCCCCCCCCCCCC	35.72	9295322
341	Phosphorylation	RVRSQEPTVGPPEKT CCCCCCCCCCCCCCC	37.02	-
348	Phosphorylation	TVGPPEKTEEEDEEE CCCCCCCCCCCCCCC	47.14	9295322

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SSR3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SSR3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SSR3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SMS_HUMAN	SST	physical	1337145
MPDZ_HUMAN	MPDZ	physical	19071123
MPDZ_RAT	Mpdz	physical	19071123
ZO1_HUMAN	TJP1	physical	19071123
SCRIB_HUMAN	SCRIB	physical	19071123
ZO2_HUMAN	TJP2	physical	19071123
MAGI3_HUMAN	MAGI3	physical	19071123
MAGI1_HUMAN	MAGI1	physical	19071123
MPP6_HUMAN	MPP6	physical	19071123
HSP74_HUMAN	HSPA4	physical	19071123
GOPC_HUMAN	GOPC	physical	19071123

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• D00442: Octreotide (USAN/INN)
• D02108: Indium In 111 pentetreotide (USP); OctreoScan (TN)
• D02250: Octreotide acetate (JAN); Octreotide diacetate; Sandostatin (TN)
• D04666: Lanreotide acetate (JAN/USAN); Somatuline (TN)
• D05230: Octreotide pamoate (USAN)
• D06281: Vapreotide (USAN/INN)
• D06495: Octreotide acetate (USAN); Sandostatin (TN)
• D07431: Somatostatin (INN)
• D09988: Vapreotide acetate (USAN)
• DrugBank
• There are no disease associations of PTM sites.