MPDZ_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MPDZ_RAT
• UniProt AC: O55164
• Protein Name: Multiple PDZ domain protein
• Gene Name: Mpdz
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 2054
• Subcellular Localization: Endomembrane system. Cell junction, tight junction. Cell junction, synapse. Apical cell membrane. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, dendrite. Cell junction, synapse, synaptosome. Associated wit
• Protein Description: Interacts with HTR2C and provokes its clustering at the cell surface. Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses..
• Protein Sequence: MLETIDKNRALQAAERLQSKLKERGDVANEDKLSLLKSVLQSPLFSQILSLQTSLQQLKDQVNVATLATANADHAHTPQFSSAIISNLQSESLLLSPSNGNLEAISGPGAPPAMDGKPACEELDQLIKSMAQGRHVEIFELLKPPCGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQVLDQTITHQQAISILQKAKDTIQLVIARGSLPHISSPRISRSPSAASTVSAHSNPTHWQHVETIELVNDGSGLGFGIIGGKATGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMIARGAVEETPAPSSLGITLSSSTSTSEMRVDASTQKNEESETFDVELTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVELDGRIQIGDQIVAVDGTNLQGFTNQQAVEVLRHTGQTVRLTLMRKGASQEAEITSREDTAKDVDLPAENYEKDEESLSLKRSTSILPIEEEGYPLLSTELEETEDVQQEAALLTKWQRIMGINYEIVVAHVSKFSENSGLGISLEATVGHHFIRSVLPEGPVGHSGKLFSGDELLEVNGINLLGENHQDVVNILKELPIDVTMVCCRRTVPPTALSEVDSLDIHDLELTEKPHIDLGEFIGSSETEDPMLAMSDVDQNAEEIQTPLAMWEAGIQAIELEKGSRGLGFSILDYQDPIDPANTVIVIRSLVPGGIAEKDGRLFPGDRLMFVNDINLENSTLEEAVEALKGAPSGMVRIGVAKPLPLSPEEGYVSAKEDTFLCSPHTCKEMGLSDKALFRADLALIDTPDAESVAESRFESQFSPDNDSVYSTQASVLSLHDGACSDGMNYGPSLPSSPPKDVTNSSDLVLGLHLSLEELYTQNLLQRQHAGSPPTDMSPAATSGFTVSDYTPANAVEQKYECANTVAWTPSQLPSGLSTTELAPALPAVAPKYLTEQSSLVSDAESVTLQSMSQEAFERTVTIAKGSSSLGMTVSANKDGLGVIVRSIIHGGAISRDGRIAVGDCILSINEESTISLTNAQARAMLRRHSLIGPDIKITYVPAEHLEEFRVSFGQQAGGIMALDIFSSYTGRDIPELPEREEGEGEESELQNAAYSSWSQPRRVELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKAGSPVVFMVQSIVNRPRKSPLPSLPHSLYPKCSFSSTNPFAESLQLTSDKAPSQSESESEKATLCSVPSSSPSVFSEMSSDYAQPSATTVAEDEDKEDEFGYSWKNIQERYGTLTGQLHMIELEKGHSGLGLSLAGNKDRTRMSVFIVGIDPTGAAGRDGRLQIADELLEINGQILYGRSHQNASSIIKCAPSKVKIIFIRNADAVNQMAVCPGSAADPLPSTSESPQNKEVEPSITTSASAVDLSSLTNVYHLELPKDQGGLGIAICEEDTLNGVTIKSLTERGGAAKDGRLKPGDRILAVDDELVAGCPIEKFISLLKTAKTTVKLTVGAENPGCQAVPSAAVTASGERKDSSQTPAVPAPDLEPIPSTSRSSTPAIFASDPATCPIIPGCETTIEISKGQTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYRDEAPYKEEDVCDTFTVELQKRPGKGLGLSIVGKRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKCSLGTVTLEVGRIKAAPFHSERRPSQSSQVSESSLSSFSLPRSGIHTSESSESSAKKNALASEIQGLRTVEIKKGPADALGLSIAGGVGSPLGDVPIFIAMMHPNGVAAQTQKLRVGDRIVTICGTSTDGMTHTQAVNLMKNASGSIEVQVVAGGDVSVVTGHQQELANPCLAFTGLTSSTIFPDDLGPPQSKTITLDRGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAAAEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLMVLS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
230	Phosphorylation	RGSLPHISSPRISRS CCCCCCCCCCCCCCC	31.12	27097102
231	Phosphorylation	GSLPHISSPRISRSP CCCCCCCCCCCCCCC	20.00	27097102
342	Phosphorylation	ARGAVEETPAPSSLG EECCCCCCCCCCCCC	15.96	26022182
346	Phosphorylation	VEETPAPSSLGITLS CCCCCCCCCCCEEEE	40.06	26022182
347	Phosphorylation	EETPAPSSLGITLSS CCCCCCCCCCEEEEC	29.56	26022182
465	Phosphorylation	TLMRKGASQEAEITS EEEECCCCCCEEECC	36.90	21630457
493	Phosphorylation	NYEKDEESLSLKRST HCCCCHHHHCCCCCC	22.62	30181290
495	Phosphorylation	EKDEESLSLKRSTSI CCCHHHHCCCCCCCE	40.92	22673903
782	Phosphorylation	VAKPLPLSPEEGYVS ECCCCCCCCCCCCCC	28.46	30240740
907	Phosphorylation	LQRQHAGSPPTDMSP HHHCCCCCCCCCCCC	28.61	27097102
910	Phosphorylation	QHAGSPPTDMSPAAT CCCCCCCCCCCCCCC	47.95	27097102
913	Phosphorylation	GSPPTDMSPAATSGF CCCCCCCCCCCCCCC	17.75	27097102
917	Phosphorylation	TDMSPAATSGFTVSD CCCCCCCCCCCCCCC	31.33	27097102
918	Phosphorylation	DMSPAATSGFTVSDY CCCCCCCCCCCCCCC	27.47	27097102
921	Phosphorylation	PAATSGFTVSDYTPA CCCCCCCCCCCCCCC	23.72	27097102
923	Phosphorylation	ATSGFTVSDYTPANA CCCCCCCCCCCCCCH	23.11	27097102
925	Phosphorylation	SGFTVSDYTPANAVE CCCCCCCCCCCCHHH	13.71	27097102
1065	Phosphorylation	RAMLRRHSLIGPDIK HHHHHHHCCCCCCCE	21.63	25403869
1157	Methylation	GISIVGGRGMGSRLS CEEEECCCCCCCCCC	26.46	-
1270	Phosphorylation	LTSDKAPSQSESESE CCCCCCCCCCCCHHH	51.72	29779826
1439	Phosphorylation	SAADPLPSTSESPQN CCCCCCCCCCCCCCC	52.85	27097102
1440	Phosphorylation	AADPLPSTSESPQNK CCCCCCCCCCCCCCC	34.28	27097102
1441	Phosphorylation	ADPLPSTSESPQNKE CCCCCCCCCCCCCCC	40.18	27097102
1443	Phosphorylation	PLPSTSESPQNKEVE CCCCCCCCCCCCCCC	31.39	27097102
1452	Phosphorylation	QNKEVEPSITTSASA CCCCCCCCCCCCCCE	21.04	23984901
1454	Phosphorylation	KEVEPSITTSASAVD CCCCCCCCCCCCEEC	21.02	23984901
1455	Phosphorylation	EVEPSITTSASAVDL CCCCCCCCCCCEECH	22.18	23984901
1456	Phosphorylation	VEPSITTSASAVDLS CCCCCCCCCCEECHH	16.15	23984901
1458	Phosphorylation	PSITTSASAVDLSSL CCCCCCCCEECHHHC	28.70	23984901
1463	Phosphorylation	SASAVDLSSLTNVYH CCCEECHHHCCCEEE	20.88	23984901
1464	Phosphorylation	ASAVDLSSLTNVYHL CCEECHHHCCCEEEE	46.65	23984901
1466	Phosphorylation	AVDLSSLTNVYHLEL EECHHHCCCEEEEEC	25.28	30181290
1534	Phosphorylation	CPIEKFISLLKTAKT CCHHHHHHHHHHCCE	30.68	25575281
1538	Phosphorylation	KFISLLKTAKTTVKL HHHHHHHHCCEEEEE	33.10	25575281
1571	Phosphorylation	ASGERKDSSQTPAVP CCCCCCCCCCCCCCC	27.64	27097102
1572	Phosphorylation	SGERKDSSQTPAVPA CCCCCCCCCCCCCCC	48.48	27097102
1574	Phosphorylation	ERKDSSQTPAVPAPD CCCCCCCCCCCCCCC	18.37	27097102
1587	Phosphorylation	PDLEPIPSTSRSSTP CCCCCCCCCCCCCCC	39.47	27097102
1588	Phosphorylation	DLEPIPSTSRSSTPA CCCCCCCCCCCCCCC	23.86	27097102
1589	Phosphorylation	LEPIPSTSRSSTPAI CCCCCCCCCCCCCCE	34.21	27097102
1591	Phosphorylation	PIPSTSRSSTPAIFA CCCCCCCCCCCCEEC	38.03	25575281
1592	Phosphorylation	IPSTSRSSTPAIFAS CCCCCCCCCCCEECC	36.98	25575281
1593	Phosphorylation	PSTSRSSTPAIFASD CCCCCCCCCCEECCC	20.27	25575281
1599	Phosphorylation	STPAIFASDPATCPI CCCCEECCCCCCCCC	33.12	25575281
1802	Phosphorylation	FHSERRPSQSSQVSE CCCCCCCCCCCCCCH	40.66	27097102
1804	Phosphorylation	SERRPSQSSQVSESS CCCCCCCCCCCCHHH	27.37	27097102
1805	Phosphorylation	ERRPSQSSQVSESSL CCCCCCCCCCCHHHH	27.28	27097102
1808	Phosphorylation	PSQSSQVSESSLSSF CCCCCCCCHHHHHCC	24.91	27097102
1810	Phosphorylation	QSSQVSESSLSSFSL CCCCCCHHHHHCCCC	29.13	27097102
1811	Phosphorylation	SSQVSESSLSSFSLP CCCCCHHHHHCCCCC	28.37	27097102
1813	Phosphorylation	QVSESSLSSFSLPRS CCCHHHHHCCCCCCC	31.14	27097102
1814	Phosphorylation	VSESSLSSFSLPRSG CCHHHHHCCCCCCCC	24.93	27097102
1816	Phosphorylation	ESSLSSFSLPRSGIH HHHHHCCCCCCCCCC	39.14	27097102
1824	Phosphorylation	LPRSGIHTSESSESS CCCCCCCCCCCCHHH	32.06	28689409
1825	Phosphorylation	PRSGIHTSESSESSA CCCCCCCCCCCHHHH	22.71	28689409
1827	Phosphorylation	SGIHTSESSESSAKK CCCCCCCCCHHHHHH	38.89	28689409

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MPDZ_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MPDZ_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MPDZ_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CSPG4_RAT	Cspg4	physical	10967549
PKHG5_RAT	Plekhg5	physical	18537874

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.