PKHG5_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PKHG5_RAT
• UniProt AC: Q6RFZ7
• Protein Name: Pleckstrin homology domain-containing family G member 5
• Gene Name: Plekhg5
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 1039
• Subcellular Localization: Cytoplasm . Cytoplasm, perinuclear region . Cell membrane . Cell junction . Cell projection, lamellipodium . Predominantly cytoplasmic, however when endothelial cells are stimulated with lysophosphatidic acid, PLEKHG5 is found in perinuclear regions
• Protein Description: Guanine nucleotide exchange factor that activates RHOA and maybe the NF-kappa-B signaling pathway. Involved in the control of neuronal cell differentiation. Plays a role in angiogenesis through regulation of endothelial cells chemotaxis (By similarity)..
• Protein Sequence: MDKGRAAKVCHHADCQQLHHRGPLNLCEICDSKFHNTTHYDGHVRFDLPPQGSVLARNVSTRSCPPRTSPAGDLEEEDEGYTNGKGDRKSAGLKISKKKARRRHTDDPSKECFTLKFDLNVDIETEIVPAMKKKSLGEVLLPVFERKGIALGKVDIYLDQSNTPLSLTFEAYRFGGHYLRVKAKPGDEGKVEQGVKDSKSLSLPALRPSGAGTPVLERVDPQSRRESSLDILAPGRRRKNMSEFLGDTSIPGQESPAPSSCSLPVGSSVGSSGSSESWKNRAASRFSGFFSSSPSTGAFGREVDKMEQLESKLHAYSLFGLPRMPRRLRFDHDSWEEEEDDEEEEDNSGLRLEDSWRELIDGHEKLTRRQCHQQEAVWELLHTEVSYIRKLRVITNLFLCCLLNLQESGLLCEVEAERLFSNIPELARLHRGLWSSVMVPVLEKARRTRALLQPSDFLKGFKMFGSLFKPYIRYCMEEEGCMEYMRSLLRDNDLFRAYVTWAEKHQQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTDEPRAKEAIITMISSVERFIHHVNTCMRQRQERQRLAGVVSRIDAYEVVEGSNDEVDKFLKEFLHLDLTAPMPGTSPEETRQLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTKAVKKAERTKVIRPPLLVDKIVCRELRDPGSFLLIHLNEFHSAVGAYTFQASSQALCRSWVDTLYNAQNQLQQLRAQLLCAQEHPGTQHLQSLEEEEDEQEEEGEESGTSAASSPTILRKSSNSLDSEHCASDGSTETLAMVVVEPGETLSSPEFDRGPFSSQSDEASLSNTTSSITPTSELLPLGPVDGRSCSMDSAYGTLSPTSLQDFAAPHPVVEPVPVPQTLSPQPSPRLRRRTPVQLLPRLPHLLKSKSEASLLQLLSGTTTSVSPPAPSRSLSELCLITMAPGVRTQSSLQEGGPGWNCPGACGPCQGPPLSESENRPSHKAGGPADSARRKCREMPCGTVPRVQPEPSPGISAQHRKLTLAQLYRIRTTLLLNSTLTASEV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
105	Phosphorylation	KKARRRHTDDPSKEC HHHHHHCCCCCCCCC	40.04	25575281
109	Phosphorylation	RRHTDDPSKECFTLK HHCCCCCCCCCEEEE	48.35	25575281
200	Phosphorylation	QGVKDSKSLSLPALR CCCCCCCCCCCCCCC	27.43	27097102
202	Phosphorylation	VKDSKSLSLPALRPS CCCCCCCCCCCCCCC	39.12	27097102
209	Phosphorylation	SLPALRPSGAGTPVL CCCCCCCCCCCCCCH	34.54	27097102
213	Phosphorylation	LRPSGAGTPVLERVD CCCCCCCCCCHHCCC	15.08	27097102
291	Phosphorylation	SRFSGFFSSSPSTGA HHHCCCCCCCCCCCC	27.87	30181290
292	Phosphorylation	RFSGFFSSSPSTGAF HHCCCCCCCCCCCCC	40.90	30181290
293	Phosphorylation	FSGFFSSSPSTGAFG HCCCCCCCCCCCCCC	22.98	30181290
295	Phosphorylation	GFFSSSPSTGAFGRE CCCCCCCCCCCCCCC	41.23	30181290
296	Phosphorylation	FFSSSPSTGAFGREV CCCCCCCCCCCCCCC	35.59	30181290
614	Phosphorylation	TAPMPGTSPEETRQL CCCCCCCCHHHHHHH	35.91	26022182
760	Phosphorylation	EEGEESGTSAASSPT HHHHCCCCCCCCCCC	25.19	-
765	Phosphorylation	SGTSAASSPTILRKS CCCCCCCCCCEECCC	22.72	-
856	Phosphorylation	AYGTLSPTSLQDFAA CCCCCCCCCHHHCCC	38.40	28689409
876	Phosphorylation	EPVPVPQTLSPQPSP ECCCCCCCCCCCCCC	24.12	28689409
878	Phosphorylation	VPVPQTLSPQPSPRL CCCCCCCCCCCCCCC	25.52	28689409
882	Phosphorylation	QTLSPQPSPRLRRRT CCCCCCCCCCCCCCC	19.87	28689409
903	Phosphorylation	RLPHLLKSKSEASLL CCHHHHCCCCHHHHH	41.19	27097102
905	Phosphorylation	PHLLKSKSEASLLQL HHHHCCCCHHHHHHH	45.55	27097102
908	Phosphorylation	LKSKSEASLLQLLSG HCCCCHHHHHHHHHC	26.09	27097102
914	Phosphorylation	ASLLQLLSGTTTSVS HHHHHHHHCCCCCCC	42.56	23984901
916	Phosphorylation	LLQLLSGTTTSVSPP HHHHHHCCCCCCCCC	24.43	23984901
917	Phosphorylation	LQLLSGTTTSVSPPA HHHHHCCCCCCCCCC	22.16	23984901
918	Phosphorylation	QLLSGTTTSVSPPAP HHHHCCCCCCCCCCC	27.28	23984901
919	Phosphorylation	LLSGTTTSVSPPAPS HHHCCCCCCCCCCCC	20.64	23984901
921	Phosphorylation	SGTTTSVSPPAPSRS HCCCCCCCCCCCCCC	25.57	27097102
926	Phosphorylation	SVSPPAPSRSLSELC CCCCCCCCCCHHHHH	36.29	27097102
928	Phosphorylation	SPPAPSRSLSELCLI CCCCCCCCHHHHHHH	40.35	27097102
930	Phosphorylation	PAPSRSLSELCLITM CCCCCCHHHHHHHHC	29.75	27097102

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PKHG5_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PKHG5_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PKHG5_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MPDZ_RAT	Mpdz	physical	18537874

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.