NKG2C_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NKG2C_HUMAN
• UniProt AC: P26717
• Protein Name: NKG2-C type II integral membrane protein
• Gene Name: KLRC2
• Organism: Homo sapiens (Human).
• Sequence Length: 231
• Subcellular Localization: Membrane; Single-pass type II membrane protein.
• Protein Description: Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells..
• Protein Sequence: MSKQRGTFSEVSLAQDPKRQQRKPKGNKSSISGTEQEIFQVELNLQNPSLNHQGIDKIYDCQGLLPPPEKLTAEVLGIICIVLMATVLKTIVLIPFLEQNNSSPNTRTQKARHCGHCPEEWITYSNSCYYIGKERRTWEESLLACTSKNSSLLSIDNEEEMKFLASILPSSWIGVFRNSSHHPWVTINGLAFKHKIKDSDNAELNCAVLQVNRLKSAQCGSSMIYHCKHKL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
100	N-linked_Glycosylation	LIPFLEQNNSSPNTR HHHHHHHCCCCCCHH	40.76	UniProtKB CARBOHYD
149	N-linked_Glycosylation	LLACTSKNSSLLSID HHHHCCCCCCCCCCC	36.28	UniProtKB CARBOHYD
178	N-linked_Glycosylation	SWIGVFRNSSHHPWV HHEEEECCCCCCCEE	36.08	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NKG2C_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NKG2C_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NKG2C_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KLRD1_HUMAN	KLRD1	physical	10320637

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.