SENP2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SENP2_MOUSE
• UniProt AC: Q91ZX6
• Protein Name: Sentrin-specific protease 2
• Gene Name: Senp2
• Organism: Mus musculus (Mouse).
• Sequence Length: 588
• Subcellular Localization: Isoform 1: Nucleus, nuclear pore complex . Nucleus membrane ; Peripheral membrane protein ; Nucleoplasmic side . Shuttles between cytoplasm and nucleus.; Isoform 2: Cytoplasm. Cytoplasmic vesicle. Found in the cytoplasm and in cytoplasmic vesicl
• Protein Description: Protease that catalyzes two essential functions in the SUMO pathway. The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway. Deconjugates SUMO2 from MTA1 (By similarity). Plays a dynamic role in adipogenesis by desumoylating and promoting the stabilization of CEBPB. [PubMed: 20194620 Isoform 3 activates transcription.]
• Protein Sequence: MYRWLAKVLGTILRLCERPAPGARALLKRRRSSSTLFSTAVDTDEIPAKRPRLDCFIHQVKNSLYNAASLFGFPFQLTTKPMVSSACNGTRNVAPSGEVFSNSSSCELMSSGSCSSMLKLGNKSPNGISDYPKIRVTVTRDQPRRVLPSFGFTLKSEGYNRRPSGRRHSKSNPESSLTWKPQEQGVTEMISEEGGKGVRRPHCTVEEGVQKDEREKYRKLLERLKEGAHGSTFPPTVSHHSSQRIQMDTLKTKGWVEEQNHGVRTTHFVPKQYRVVETRGPLCSMRSEKRYSKGKADTEKVVGLRFEKEGTRGHQMEPDLSEEVSARLRLGSGSNGLLRRKISVLEIKEKNFPSKEKDRRTEDLFEFTEDMEKEISNALGHGPPDEILSSAFKLRITRGDIQTLKNYHWLNDEVINFYMNLLVERSKKQGYPALHAFSTFFYPKLKSGGYQAVKRWTKGVNLFEQELVLVPIHRKVHWSLVVMDLRKKCLKYLDSMGQKGHRICEILLQYLQDESKTKRNTDLNLLEWTHYSMKPHEIPQQLNGSDCGMFTCKYADYISRDKPITFTQHQMPLFRKKMVWEILHQQLL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
32	Phosphorylation	ALLKRRRSSSTLFST HHHHHHHCCCCCEEC	27.16	25159016
33	Phosphorylation	LLKRRRSSSTLFSTA HHHHHHCCCCCEECC	26.07	25159016
34	Phosphorylation	LKRRRSSSTLFSTAV HHHHHCCCCCEECCC	30.31	25159016
35	Phosphorylation	KRRRSSSTLFSTAVD HHHHCCCCCEECCCC	33.50	25159016
38	Phosphorylation	RSSSTLFSTAVDTDE HCCCCCEECCCCCCC	20.69	25293948
43	Phosphorylation	LFSTAVDTDEIPAKR CEECCCCCCCCCCCC	29.00	29899451
124	Phosphorylation	MLKLGNKSPNGISDY HHHCCCCCCCCCCCC	27.83	22817900
131	Phosphorylation	SPNGISDYPKIRVTV CCCCCCCCCCEEEEE	10.30	28059163
178	Phosphorylation	SNPESSLTWKPQEQG CCCCCCCCCCCHHCC	33.13	-
273	Phosphorylation	THFVPKQYRVVETRG EEECCCEEEEEEECC	16.11	29514104
332	Phosphorylation	SARLRLGSGSNGLLR HHHHHCCCCCCHHHH	43.57	26643407
334	Phosphorylation	RLRLGSGSNGLLRRK HHHCCCCCCHHHHCC	29.44	28066266
343	Phosphorylation	GLLRRKISVLEIKEK HHHHCCEEEEEHHHH	24.55	26824392
368	Phosphorylation	TEDLFEFTEDMEKEI HHHHHHHCHHHHHHH	24.71	-
376	Phosphorylation	EDMEKEISNALGHGP HHHHHHHHHHHCCCC	19.69	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
35	T	Phosphorylation	Kinase	RPS6KA1	Q15418	GPS
38	S	Phosphorylation	Kinase	RPS6KA1	Q15418	GPS
368	T	Phosphorylation	Kinase	RPS6KA1	Q15418	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SENP2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SENP2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MDM2_MOUSE	Mdm2	physical	21183956
RAGP1_HUMAN	RANGAP1	physical	12419228
PML_HUMAN	PML	physical	12419228

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.