PTC1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PTC1_MOUSE
• UniProt AC: Q61115
• Protein Name: Protein patched homolog 1
• Gene Name: Ptch1
• Organism: Mus musculus (Mouse).
• Sequence Length: 1434
• Subcellular Localization: Membrane; Multi-pass membrane protein.
• Protein Description: Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis..
• Protein Sequence: MASAGNAAGALGRQAGGGRRRRTGGPHRAAPDRDYLHRPSYCDAAFALEQISKGKATGRKAPLWLRAKFQRLLFKLGCYIQKNCGKFLVVGLLIFGAFAVGLKAANLETNVEELWVEVGGRVSRELNYTRQKIGEEAMFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELITETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAYLLGKPPLRWTNFDPLEFLEELKKINYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDVALVLNGGCQGLSRKYMHWQEELIVGGTVKNATGKLVSAHALQTMFQLMTPKQMYEHFRGYDYVSHINWNEDRAAAILEAWQRTYVEVVHQSVAPNSTQKVLPFTTTTLDDILKSFSDVSVIRVASGYLLMLAYACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVSRVIQVEPQAYTEPHSNTRYSPPPPYTSHSFAHETHITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVTVTQDNLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEKHYAPFLLKPKAKVVVILLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQKADYPNIQHLLYDLHKSFSNVKYVMLEENKQLPQMWLHYFRDWLQGLQDAFDSDWETGRIMPNNYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDPVAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAIEKVRVICNNYTSLGLSSYPNGYPFLFWEQYISLRHWLLLSISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDKNHRAMLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRYFFAVLAILTVLGVLNGLVLLPVLLSFFGPCPEVSPANGLNRLPTPSPEPPPSVVRFAVPPGHTNNGSDSSDSEYSSQTTVSGISEELRQYEAQQGAGGPAHQVIVEATENPVFARSTVVHPDSRHQPPLTPRQQPHLDSGSLSPGRQGQQPRRDPPREGLRPPPYRPRRDAFEISTEGHSGPSNRDRSGPRGARSHNPRNPTSTAMGSSVPSYCQPITTVTASASVTVAVHPPPGPGRNPRGGPCPGYESYPETDHGVFEDPHVPFHVRCERRDSKVEVIELQDVECEERPWGSSSN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
127	N-linked_Glycosylation	GRVSRELNYTRQKIG HHHHHHHCCCCHHHC	31.23	-
255	Ubiquitination	LEFLEELKKINYQVD HHHHHHHHHHCCCCC	55.69	-
263	Phosphorylation	KINYQVDSWEEMLNK HHCCCCCCHHHHHHH	37.21	29514104
298	N-linked_Glycosylation	PATAPNKNSTKPLDV CCCCCCCCCCCCCEE	62.64	-
335	N-linked_Glycosylation	IVGGTVKNATGKLVS ECCCEEECCCCCCCH	38.10	-
400	N-linked_Glycosylation	VHQSVAPNSTQKVLP EHHCCCCCCCCCCCC	48.21	-
652	Phosphorylation	QSTVQLRTEYDPHTH EEEEEEECCCCCCCE	47.71	21930439
861	N-linked_Glycosylation	IMPNNYKNGSDDGVL CCCCCCCCCCCCCCC	44.86	-
986	N-linked_Glycosylation	KVRVICNNYTSLGLS HHHHHCCCCCCCCCC	36.73	-
1065	Phosphorylation	GLIGIKLSAVPVVIL HHHHHHCCCCCEEEE	23.40	-
1075	Phosphorylation	PVVILIASVGIGVEF CEEEEECCCCCCCCH	17.55	-
1181	Phosphorylation	NGLNRLPTPSPEPPP CCCCCCCCCCCCCCC	40.78	22817900
1183	Phosphorylation	LNRLPTPSPEPPPSV CCCCCCCCCCCCCCE	44.36	26824392
1189	Phosphorylation	PSPEPPPSVVRFAVP CCCCCCCCEEEEECC	38.73	28066266
1276	Phosphorylation	RQQPHLDSGSLSPGR CCCCCCCCCCCCCCC	36.32	25338131
1278	Phosphorylation	QPHLDSGSLSPGRQG CCCCCCCCCCCCCCC	29.62	27566939
1280	Phosphorylation	HLDSGSLSPGRQGQQ CCCCCCCCCCCCCCC	27.31	27566939
1413	Ubiquitination	RCERRDSKVEVIELQ EECCCCCCEEEEEEE	46.86	25092867

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PTC1_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
1413	K	ubiquitylation	In the absence of Hh ligands, ubiquitination by ITCH at Lys-1413 promotes endocytosis and both proteasomal and lysosomal degradation.	25092867

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PTC1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PTC1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.