| UniProt ID | RASF1_MOUSE | |
|---|---|---|
| UniProt AC | Q99MK9 | |
| Protein Name | Ras association domain-containing protein 1 | |
| Gene Name | Rassf1 {ECO:0000312|EMBL:AAK21200.1} | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 340 | |
| Subcellular Localization | Isoform A: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Localizes to cytoplasmic microtubules during interphase, to bipolar centr | |
| Protein Description | Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage (By similarity).. | |
| Protein Sequence | MSAEPELIELRELAPSGRIGPGRTRLERANALRIAPGTTRNPSQQHVPGRGHRFQPAGPTTHTWCDLCGDFIWGVVRKGLQCAHCKFTCHYRCRALVCLDCCGPRDLGWDSALERDTNVDEAVERETPDLSQAETEQKIKDYNGQINSNLFMSLNKDGSYTGFIKVQLKLVRPVSVPSSKKPPSLQDARRGTGRSTAVKRRTSFYLPKDAIKHLHVLSRTRAREVIEALLRKFMVVDDPRKFALFERTERHGQVYLRKLSDDEQPLKLRLLAGPSEKALSFVLKENDSGEVNWDAFSMPELHNFLRILQREEEEHLRQILQKYSRCRQKIQEALHACPLG | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MSAEPELIE ------CCCCHHHHH | 41.14 | - | |
| 2 | Phosphorylation | ------MSAEPELIE ------CCCCHHHHH | 41.14 | 28066266 | |
| 12 (in isoform 2) | Phosphorylation | - | 63.01 | - | |
| 43 | Phosphorylation | PGTTRNPSQQHVPGR CCCCCCHHHCCCCCC | 46.12 | 27566939 | |
| 133 (in isoform 1) | Phosphorylation | - | 23.46 | 24719451 | |
| 142 | Phosphorylation | TEQKIKDYNGQINSN HHHHHHHCCCCCCCC | 19.05 | 28507225 | |
| 195 | Phosphorylation | ARRGTGRSTAVKRRT HHCCCCCCHHHHHCC | 23.28 | 29899451 | |
| 202 | Phosphorylation | STAVKRRTSFYLPKD CHHHHHCCCEECCHH | 27.50 | 25159016 | |
| 203 | Phosphorylation | TAVKRRTSFYLPKDA HHHHHCCCEECCHHH | 15.30 | 28418008 | |
| 205 | Phosphorylation | VKRRTSFYLPKDAIK HHHCCCEECCHHHHH | 23.12 | 25159016 | |
| 255 | Phosphorylation | TERHGQVYLRKLSDD CHHCCEEEEEECCCC | 7.91 | 22499769 | |
| 260 | Phosphorylation | QVYLRKLSDDEQPLK EEEEEECCCCCCCEE | 46.15 | 28066266 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RASF1_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RASF1_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RASF1_MOUSE !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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