NFX1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NFX1_MOUSE
• UniProt AC: B1AY10
• Protein Name: Transcriptional repressor NF-X1
• Gene Name: Nfx1
• Organism: Mus musculus (Mouse).
• Sequence Length: 1114
• Subcellular Localization: Nucleus.
• Protein Description: Binds to the X-box motif of MHC class II genes and represses their expression. May play an important role in regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced by interferon-gamma. Together with PABPC1 or PABPC4, acts as a coactivator for TERT expression. Mediates E2-dependent ubiquitination..
• Protein Sequence: MAEAPPVSGTFKFNTDAAEFIPQERKTSGLNCGTQRRLDSSRIGRRNYSSSPPCHLPRHIPYEDISAVHQHSYASGSKPKSPQGFFQSSNKSLKNHGLQNQPWQKARNEKHQNRNKKAQGLSEQTSDTSSLESVARSESGTNPREHSPSESEKEVVIADPRGAKPKKAAQLTYNYGRGPKAKGRLRSEWGNRMSPKSEDENTRPVAISHTDSSDASCRKPVVDPCVCRRNEQRRYPQKRPPWEVEGARPRPGRNPPKQESQRHINAGPKTNMSPIPKDNLRERPTKSACDTGNLAVVSKSSRRVNQEKTAVRRQDPQVLSPFPRGKQNHMLKNVETHTGSLIEQLTTEKYECMVCCELVQVTAPVWSCQSCFHVFHLNCIKKWARSPASHADGQSGWRCPACQNVSAHVPNTYTCFCGKVKNPEWSRNEIPHSCGEVCRKKQPGQDCPHSCNLLCHPGPCPPCPAFTTKTCECGRTRHTVRCGQPVSVHCSNACENILNCGQHHCAELCHGGQCQPCRIILNQVCYCGSTSRDVLCGTDVGKSDGFGDFSCLKICGKDLKCGSHTCSQVCHPQPCQPCPRLPHLVRYCPCGQTPLSQLLEHGSNARKTCMDPVPSCGKVCGKPLACGSSDFIHTCEKLCHEGDCGPCSRTSVISCRCSFRTKELPCTSLKSEDATFMCDKRCNKKRLCGRHKCNEICCVDKEHKCPLICGRKLRCGLHRCEEPCHRGNCQTCWQASFDELTCHCGASVIYPPVPCGTRPPECTQTCARIHECDHPVYHSCHSEEKCPPCTFLTQKWCMGKHELRSNIPCHLVDISCGLPCSAMLPCGMHKCQRLCHKGECLVDEACKQPCTTPRGDCGHPCMAPCHPSLPCPVTACKAKVELQCECGRRKEMVICSEASGTYQRIVAISMASKITDMQLGDSVEISKLITKKEVQQARLQCDEECAALERRKRLAEAFDITDDSDPFNVRSSASKFSDSLKDDARKDLKFVSDVEKEMETLVEAVNKGKNNKKSHCFPPMNRDHRRIIHDLAQVYGLESISYDSEPKRNVVVTAVRGKSVCPPTTLTSVIERETQTRPPPPIPHHRHQADKAPGSSTLQKIVKEAVIDYFDVQD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MAEAPPVSGTFKFNT CCCCCCCCCEEEECC	37.58	-
34	Phosphorylation	TSGLNCGTQRRLDSS CCCCCCCCCCCCCCC	22.54	28059163
48	Phosphorylation	SRIGRRNYSSSPPCH CCCCCCCCCCCCCCC	14.23	25619855
49	Phosphorylation	RIGRRNYSSSPPCHL CCCCCCCCCCCCCCC	28.08	26824392
50	Phosphorylation	IGRRNYSSSPPCHLP CCCCCCCCCCCCCCC	36.18	25521595
51	Phosphorylation	GRRNYSSSPPCHLPR CCCCCCCCCCCCCCC	27.24	25521595
62	Phosphorylation	HLPRHIPYEDISAVH CCCCCCCHHHHHHHH	26.15	25367039
66	Phosphorylation	HIPYEDISAVHQHSY CCCHHHHHHHHHCCC	36.24	25777480
72	Phosphorylation	ISAVHQHSYASGSKP HHHHHHCCCCCCCCC	18.80	25777480
73	Phosphorylation	SAVHQHSYASGSKPK HHHHHCCCCCCCCCC	11.58	25777480
75	Phosphorylation	VHQHSYASGSKPKSP HHHCCCCCCCCCCCC	35.05	25777480
77	Phosphorylation	QHSYASGSKPKSPQG HCCCCCCCCCCCCCC	43.20	25777480
81	Phosphorylation	ASGSKPKSPQGFFQS CCCCCCCCCCCCCCC	30.86	25521595
88	Phosphorylation	SPQGFFQSSNKSLKN CCCCCCCCCCHHHHH	30.62	25777480
89	Phosphorylation	PQGFFQSSNKSLKNH CCCCCCCCCHHHHHC	37.18	25777480
91	Ubiquitination	GFFQSSNKSLKNHGL CCCCCCCHHHHHCCC	60.14	22790023
92	Phosphorylation	FFQSSNKSLKNHGLQ CCCCCCHHHHHCCCC	49.15	-
117	Ubiquitination	KHQNRNKKAQGLSEQ HHHHHHHHHCCCCCC	49.87	-
122	Phosphorylation	NKKAQGLSEQTSDTS HHHHCCCCCCCCCCC	34.19	25293948
125	Phosphorylation	AQGLSEQTSDTSSLE HCCCCCCCCCCCHHH	25.23	25293948
126	Phosphorylation	QGLSEQTSDTSSLES CCCCCCCCCCCHHHH	38.29	25521595
128	Phosphorylation	LSEQTSDTSSLESVA CCCCCCCCCHHHHHH	21.71	25521595
129	Phosphorylation	SEQTSDTSSLESVAR CCCCCCCCHHHHHHH	37.61	19060867
130	Phosphorylation	EQTSDTSSLESVARS CCCCCCCHHHHHHHC	37.94	30352176
133	Phosphorylation	SDTSSLESVARSESG CCCCHHHHHHHCCCC	26.77	25293948
137	Phosphorylation	SLESVARSESGTNPR HHHHHHHCCCCCCCC	26.78	27087446
139	Phosphorylation	ESVARSESGTNPREH HHHHHCCCCCCCCCC	52.76	25266776
141	Phosphorylation	VARSESGTNPREHSP HHHCCCCCCCCCCCC	51.86	26643407
147	Phosphorylation	GTNPREHSPSESEKE CCCCCCCCCCHHHCC	25.93	27087446
149	Phosphorylation	NPREHSPSESEKEVV CCCCCCCCHHHCCEE	57.69	27742792
151	Phosphorylation	REHSPSESEKEVVIA CCCCCCHHHCCEEEE	59.30	27087446
167	Ubiquitination	PRGAKPKKAAQLTYN CCCCCCCHHHHCEEC	58.44	-
173	Phosphorylation	KKAAQLTYNYGRGPK CHHHHCEECCCCCCC	18.25	29514104
175	Phosphorylation	AAQLTYNYGRGPKAK HHHCEECCCCCCCCC	9.59	29514104
194	Phosphorylation	SEWGNRMSPKSEDEN CCCCCCCCCCCCCCC	26.41	25266776
196	Ubiquitination	WGNRMSPKSEDENTR CCCCCCCCCCCCCCC	60.20	-
197	Phosphorylation	GNRMSPKSEDENTRP CCCCCCCCCCCCCCC	54.38	25266776
202	Phosphorylation	PKSEDENTRPVAISH CCCCCCCCCCEEEEE	34.01	29550500
208	Phosphorylation	NTRPVAISHTDSSDA CCCCEEEEECCCCCC	15.59	29472430
269	Ubiquitination	RHINAGPKTNMSPIP HHHCCCCCCCCCCCC	52.17	-
273	Phosphorylation	AGPKTNMSPIPKDNL CCCCCCCCCCCCCCC	23.03	29472430
286	Ubiquitination	NLRERPTKSACDTGN CCCCCCCCCCCCCCC	38.44	-
300	Phosphorylation	NLAVVSKSSRRVNQE CEEEEECCCCCCCHH	22.90	28464351
301	Phosphorylation	LAVVSKSSRRVNQEK EEEEECCCCCCCHHH	28.04	28464351
320	Phosphorylation	RQDPQVLSPFPRGKQ HCCCCCCCCCCCCCC	26.16	25266776
926	Phosphorylation	LGDSVEISKLITKKE CCCCCHHHHHCCHHH	14.12	28285833
1035	Phosphorylation	IHDLAQVYGLESISY HHHHHHHHCCCCCCC	12.15	28059163
1039	Phosphorylation	AQVYGLESISYDSEP HHHHCCCCCCCCCCC	23.13	21183079
1042	Phosphorylation	YGLESISYDSEPKRN HCCCCCCCCCCCCCC	23.09	22871156
1044	Phosphorylation	LESISYDSEPKRNVV CCCCCCCCCCCCCEE	47.79	22871156

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NFX1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NFX1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NFX1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of NFX1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.