FEZ1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FEZ1_MOUSE
• UniProt AC: Q8K0X8
• Protein Name: Fasciculation and elongation protein zeta-1
• Gene Name: Fez1
• Organism: Mus musculus (Mouse).
• Sequence Length: 392
• Subcellular Localization: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell membrane. Colocalizes with both, alpha- and gamma-tubulin. Translocated from the plasma membrane to the cytoplasm by activation of the PKC zeta (By similarity)..
• Protein Description: May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. May participate in the transport of mitochondria and other cargos along microtubules (By similarity)..
• Protein Sequence: MEAPLVSLDEEFEDIRPSCTEEPEEKPQCLYGTSPHHLEDPSLSELENFSSEIISFKSMEDLVNEFDEKLNVCFRNYNAKTESLAPVKNQLQIQEEEETLRDEEVWDALTDNYIPSLSEDWRDPNIEALNGNSSDIEIHEKEEEEFNEKSENDSGINEEPLLTADQVIEEIEEMMQNSPDPEEEEEVLEEEDGGEISSQADSVLLQEMQALTQTFNNNWSYEGLRHMSGSELTELLDRVEGAIRDFSEELVHQLARRDELEFEKEVKNSFITVLIEVQNKQREQRELMKKRRKEKGLSLQSNRIEKGSQMPLKRFSMEGISNILQSGIRQTFGSSGADRQYLNTVIPYEKKSSPPSVEDLQMLTNILFAMKEDNEKVPTLLTDYILKVLCPT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
58	Phosphorylation	SEIISFKSMEDLVNE HHHCCCCCHHHHHHH	25.95	25521595
134	Phosphorylation	EALNGNSSDIEIHEK HHHCCCCCCCEEHHH	46.75	25521595
298	Phosphorylation	RRKEKGLSLQSNRIE HHHHHCCCCCCCCCC	32.79	26824392
306	Acetylation	LQSNRIEKGSQMPLK CCCCCCCCCCCCCHH	62.58	22902405
313	Acetylation	KGSQMPLKRFSMEGI CCCCCCHHHHCHHHH	45.59	22902405
316	Phosphorylation	QMPLKRFSMEGISNI CCCHHHHCHHHHHHH	21.69	25521595
321	Phosphorylation	RFSMEGISNILQSGI HHCHHHHHHHHHHCH	28.77	26643407
376	Ubiquitination	AMKEDNEKVPTLLTD HCHHCCCCCCHHHHH	60.82	22790023
379	Phosphorylation	EDNEKVPTLLTDYIL HCCCCCCHHHHHHHH	37.07	25338131
382	Phosphorylation	EKVPTLLTDYILKVL CCCCHHHHHHHHHHH	29.84	25338131
384	Phosphorylation	VPTLLTDYILKVLCP CCHHHHHHHHHHHCC	11.69	25338131

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FEZ1_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
26	K	ubiquitylation	Polyubiquitin linkage seems to be mainly through Lys-26 (By similarity).	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FEZ1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NECD_MOUSE	Ndn	physical	15649943
CDC20_MOUSE	Cdc20	physical	24726361

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-316, AND MASSSPECTROMETRY.
PubMed: 19367708

"Phosphoproteomic analysis of the developing mouse brain.";
Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.;
Mol. Cell. Proteomics 3:1093-1101(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-58, AND MASSSPECTROMETRY.
PubMed: 15345747