dbPTM

DNER_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DNER_MOUSE
UniProt AC	Q8JZM4
Protein Name	Delta and Notch-like epidermal growth factor-related receptor
Gene Name	Dner
Organism	Mus musculus (Mouse).
Sequence Length	737
Subcellular Localization	Cell membrane Single-pass type I membrane protein . Present on the membrane of dendrites and cell bodies but excluded from axonal membrane. Also found in early endosomes in the somatodendritic region.
Protein Description	Mediates neuron-glia interaction during astrocytogenesis. May promote differentiation of Bergmann glia during cerebellar development by activating DELTEX-dependent NOTCH1 signaling..
Protein Sequence	MPPRRAQAPGAPLLPVLALLPLLLGAGPQSGCLASPVSAAPLPAPGPCASQPCRNGGVCTPRSVTDQEHPAADAEPRYSCTCPAGVSGTYCQFVADPCASNPCHHGNCSSSSSSSSDSYLCICNDGYEGLNCEQPLPSIPTSGWTESTAPRQLQPVPATQEPDIILPRSQATVTLPTWQPKTGQKVVEMKWDQVEVVPDVACGNASSNNSAGGRLVSFEVPQNTSVKIRQDANSLLILLWKVTATGFQQCSLIDGRSVTPLQAPGGLVLLEEMLALGPNHFIGFVNDSVAKSIVALRLTLVVKASNCVPGDSHSNDLECSGKGKCATKPSEATFSCTCQDQYIGTFCEEFDACQRKPCQNEASCIDANEKQDGSNFTCLCLPGYTGELCQSKIDYCVLDPCRNGATCVSSLSGFTCQCLEGYFGSACEEKVDPCMSSPCQNNGTCYVDGVHFTCSCSPGFTGPTCAQLVDFCALSPCAHGMCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLINGYECVCLAEYKGTHCELYKDPCANISCLNGGTCDSEGLNGTCICAPGFTGEECDIDINECDSNPCHHAGTCLDQPNGYTCHCPHGWVGANCEIHLQWKSGHMAESLTNMPRHSLYIIIGALCVAFILMLIILIVGICRISRIEYQGSSRPAYEEFYNCRSIDSEFSNAIASIRHARFGKKSRPAMYDVTPIAYEDYSPDDKPLVTLIKTKDL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
204	N-linked_Glycosylation	VPDVACGNASSNNSA ECCCCCCCCCCCCCC	36.21	-
224	Phosphorylation	SFEVPQNTSVKIRQD EEECCCCCEEEEEEC	29.65	22345495
225	Phosphorylation	FEVPQNTSVKIRQDA EECCCCCEEEEEECH	29.03	22345495
564	N-linked_Glycosylation	TCDSEGLNGTCICAP CCCCCCCCCCEEECC	55.36	-
685	Phosphorylation	EEFYNCRSIDSEFSN HHHHCCCCCCHHHHH	32.71	22817900
688	Phosphorylation	YNCRSIDSEFSNAIA HCCCCCCHHHHHHHH	38.58	29899451
696	Phosphorylation	EFSNAIASIRHARFG HHHHHHHHHHHHHCC	17.65	29899451
711	Phosphorylation	KKSRPAMYDVTPIAY CCCCCCEEECCCCCC	14.90	22817900
714	Phosphorylation	RPAMYDVTPIAYEDY CCCEEECCCCCCCCC	13.18	22817900
718	Phosphorylation	YDVTPIAYEDYSPDD EECCCCCCCCCCCCC	15.28	22817900
721	Phosphorylation	TPIAYEDYSPDDKPL CCCCCCCCCCCCCCC	15.34	22817900
722	Phosphorylation	PIAYEDYSPDDKPLV CCCCCCCCCCCCCCE	33.89	22817900
733	Ubiquitination	KPLVTLIKTKDL--- CCCEEEEECCCC---	53.27	22790023

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of DNER_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DNER_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DNER_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of DNER_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DNER_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale identification and evolution indexing of tyrosinephosphorylation sites from murine brain."; Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.; J. Proteome Res. 7:311-318(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-711; TYR-718 ANDTYR-721, AND MASS SPECTROMETRY.	18034455 [Abstract]