CCM2_MOUSE - dbPTM
CCM2_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CCM2_MOUSE
UniProt AC Q8K2Y9
Protein Name Cerebral cavernous malformations protein 2 homolog
Gene Name Ccm2
Organism Mus musculus (Mouse).
Sequence Length 453
Subcellular Localization Cytoplasm . Treatment with sorbitol caused relocalization to ruffle-like structures.
Protein Description Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions. May also function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock..
Protein Sequence MEEEGKKGKKPGIVSPFKRVFLKGEKSRDKKAHEKVTERRPLHTVVLALPERVEPDRLLSDYIEKEVKYLGQLTSIPGYLNPSSRTEILHFIDKAKRSHQLPGHLTQEHDAVLSLSAYNVKLAWRDGEDIILRVPIHDIAAVSYVRDDAAHLVVLKTAQDPGISPSQSLCAESSRGLSAGSLSESAVGPVEACCLVIMATESKVAAEELCSLLSQVFQIVYTESTIDFLDRAIFDGASTPTHHLSLHSDDSSTKVDMKDSYDADASTFCFPDSGDVGGLPPLPFCMQTSPHSKTVSESELSTSATELLQDYMLTLRTKLSSQEIQQFAALLHEYRNGASIHEFCISLRQLYGDSRKFLLLGLRPFIPEKDSQHFENFLETIGVKDGRGIITDSFGRHRRALSTTSTSTINGNRTTGSPDDRSAPSEGDEWDRMISDISSDIEALGCSMDQDSA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
15PhosphorylationGKKPGIVSPFKRVFL
CCCCCCCCCCHHHEE		23.7727841257
69PhosphorylationYIEKEVKYLGQLTSI
HHHHHHHHHHHHCCC		22.6530635358
74PhosphorylationVKYLGQLTSIPGYLN
HHHHHHHCCCCCCCC		19.4030635358
75PhosphorylationKYLGQLTSIPGYLNP
HHHHHHCCCCCCCCC		35.0630635358
79PhosphorylationQLTSIPGYLNPSSRT
HHCCCCCCCCCCCCH		9.6530635358
83PhosphorylationIPGYLNPSSRTEILH
CCCCCCCCCCHHHHH		31.2330635358
84PhosphorylationPGYLNPSSRTEILHF
CCCCCCCCCHHHHHH		44.4730635358
157PhosphorylationAHLVVLKTAQDPGIS
CEEEEEECCCCCCCC		25.9523527152
164PhosphorylationTAQDPGISPSQSLCA
CCCCCCCCHHHHHHH		25.1425521595
166PhosphorylationQDPGISPSQSLCAES
CCCCCCHHHHHHHHH		26.1324759943
168PhosphorylationPGISPSQSLCAESSR
CCCCHHHHHHHHHCC		29.7429899451
178PhosphorylationAESSRGLSAGSLSES
HHHCCCCCCCCCCCC		33.1529899451
181PhosphorylationSRGLSAGSLSESAVG
CCCCCCCCCCCCCCC		28.5627600695
183PhosphorylationGLSAGSLSESAVGPV
CCCCCCCCCCCCCHH		31.0729899451
185PhosphorylationSAGSLSESAVGPVEA
CCCCCCCCCCCHHHH		25.5229899451
238PhosphorylationRAIFDGASTPTHHLS
HHHHCCCCCCCEECE		40.2128833060
239PhosphorylationAIFDGASTPTHHLSL
HHHCCCCCCCEECEE		31.5028833060
241PhosphorylationFDGASTPTHHLSLHS
HCCCCCCCEECEECC		23.2428833060
245PhosphorylationSTPTHHLSLHSDDSS
CCCCEECEECCCCCC		21.4928833060
248PhosphorylationTHHLSLHSDDSSTKV
CEECEECCCCCCCCC		48.7028833060
251PhosphorylationLSLHSDDSSTKVDMK
CEECCCCCCCCCCCC		44.9228833060
252PhosphorylationSLHSDDSSTKVDMKD
EECCCCCCCCCCCCC		38.9628833060
253PhosphorylationLHSDDSSTKVDMKDS
ECCCCCCCCCCCCCC		38.7528833060
289PhosphorylationLPFCMQTSPHSKTVS
CCCCEECCCCCCCCC		12.0629899451
294PhosphorylationQTSPHSKTVSESELS
ECCCCCCCCCHHHHC		32.0726745281
296PhosphorylationSPHSKTVSESELSTS
CCCCCCCCHHHHCCC		40.4127180971
298PhosphorylationHSKTVSESELSTSAT
CCCCCCHHHHCCCHH		36.0123649490
301PhosphorylationTVSESELSTSATELL
CCCHHHHCCCHHHHH		19.1026745281
302PhosphorylationVSESELSTSATELLQ
CCHHHHCCCHHHHHH		34.7026745281
303PhosphorylationSESELSTSATELLQD
CHHHHCCCHHHHHHH		29.8025338131
380PhosphorylationHFENFLETIGVKDGR
HHHHHHHHHCCCCCC		25.7725338131
391PhosphorylationKDGRGIITDSFGRHR
CCCCEEEECCCCCCC		24.5422324799
393PhosphorylationGRGIITDSFGRHRRA
CCEEEECCCCCCCCC		22.4327087446
402PhosphorylationGRHRRALSTTSTSTI
CCCCCCCCCCCCCEE		28.7525521595
403PhosphorylationRHRRALSTTSTSTIN
CCCCCCCCCCCCEEC		26.1427566939
404PhosphorylationHRRALSTTSTSTING
CCCCCCCCCCCEECC		26.9926643407
405PhosphorylationRRALSTTSTSTINGN
CCCCCCCCCCEECCC		22.0525521595
406PhosphorylationRALSTTSTSTINGNR
CCCCCCCCCEECCCC		28.0022324799
407PhosphorylationALSTTSTSTINGNRT
CCCCCCCCEECCCCC		27.3622324799
408PhosphorylationLSTTSTSTINGNRTT
CCCCCCCEECCCCCC		20.6722324799
414PhosphorylationSTINGNRTTGSPDDR
CEECCCCCCCCCCCC		39.2426643407
415PhosphorylationTINGNRTTGSPDDRS
EECCCCCCCCCCCCC		32.2124719451
417PhosphorylationNGNRTTGSPDDRSAP
CCCCCCCCCCCCCCC		24.0626643407
422PhosphorylationTGSPDDRSAPSEGDE
CCCCCCCCCCCCCCH		52.0726643407
425PhosphorylationPDDRSAPSEGDEWDR
CCCCCCCCCCCHHHH		54.6626643407
438PhosphorylationDRMISDISSDIEALG
HHHHHHHHHHHHHHC		27.2728833060
452PhosphorylationGCSMDQDSA------
CCCCCCCCC------		30.1928833060
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CCM2_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CCM2_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CCM2_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of CCM2_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CCM2_MOUSE

loading...

Related Literatures of Post-Translational Modification

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory