NTRK1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NTRK1_MOUSE
• UniProt AC: Q3UFB7
• Protein Name: High affinity nerve growth factor receptor
• Gene Name: Ntrk1
• Organism: Mus musculus (Mouse).
• Sequence Length: 799
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein . Early endosome membrane ; Single-pass type I membrane protein . Late endosome membrane ; Single-pass type I membrane protein . Internalized to endosomes upon binding of NGF or NTF3 and further tra
• Protein Description: Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand, it can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors..
• Protein Sequence: MLRGQRLGQLGWHRPAAGLGSLMTSLMLACASAASCREVCCPVGPSGLRCTRAGSLDTLRGLRGAGNLTELYVENQQHLQRLEFEDLQGLGELRSLTIVKSGLRFVAPDAFRFTPRLSHLNLSSNALESLSWKTVQGLSLQDLTLSGNPLHCSCALFWLQRWEQEGLCGVHTQTLHDSGPGDQFLPLGHNTSCGVPTVKIQMPNDSVEVGDDVFLQCQVEGLALQQADWILTELEGAATVKKFGDLPSLGLILVNVTSDLNKKNVTCWAENDVGRAEVSVQVSVSFPASVHLGLAVEQHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTQFLESALTNETMRHGCLRLNQPTHVNNGNYTLLAANPYGQAAASVMAAFMDNPFEFNPEDPIPVSFSPVDGNSTSRDPVEKKDETPFGVSVAVGLAVSAALFLSALLLVLNKCGQRSKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIMENPQYFSDTCVHHIKRQDIILKWELGEGAFGKVFLAECYNLLNDQDKMLVAVKALKEASENARQDFQREAELLTMLQHQHIVRFFGVCTEGGPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLASLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFSTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIECITQGRELERPRACPPDVYAIMRGCWQREPQQRLSMKDVHARLQALAQAPPSYLDVLG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
67	N-linked_Glycosylation	RGLRGAGNLTELYVE HCCCCCCCCEEEEEC	43.16	-
121	N-linked_Glycosylation	TPRLSHLNLSSNALE CCCCCCCCCCCHHHH	32.24	-
123	Phosphorylation	RLSHLNLSSNALESL CCCCCCCCCHHHHHC	22.07	28973931
190	N-linked_Glycosylation	QFLPLGHNTSCGVPT CCCCCCCCCCCCCCE	31.71	-
204	N-linked_Glycosylation	TVKIQMPNDSVEVGD EEEEECCCCCEEECC	49.17	-
255	N-linked_Glycosylation	SLGLILVNVTSDLNK CCEEEEEEECCCCCC	28.09	-
264	N-linked_Glycosylation	TSDLNKKNVTCWAEN CCCCCCCCCEEEEEC	35.62	-
320	N-linked_Glycosylation	PSLRWLFNGSVLNET CCCHHHHCCCCCCCC	39.39	-
325	N-linked_Glycosylation	LFNGSVLNETSFIFT HHCCCCCCCCHHHHH	48.63	-
341	N-linked_Glycosylation	FLESALTNETMRHGC HHHHHHCCHHHHCCE	43.52	-
361	N-linked_Glycosylation	PTHVNNGNYTLLAAN CCEEECCCEEEEEEC	28.83	-
404	N-linked_Glycosylation	SFSPVDGNSTSRDPV CCCCCCCCCCCCCCC	37.34	-
499	Phosphorylation	HIMENPQYFSDTCVH CCCCCCCCCCCCHHH	13.30	21562256
679	Phosphorylation	FGMSRDIYSTDYYRV CCCCCCCEECCCEEE	15.14	-
683	Phosphorylation	RDIYSTDYYRVGGRT CCCEECCCEEECCEE	8.02	-
684	Phosphorylation	DIYSTDYYRVGGRTM CCEECCCEEECCEEE	11.13	-
776	Phosphorylation	REPQQRLSMKDVHAR CCCCCCCCHHHHHHH	26.44	30387612
794	Phosphorylation	LAQAPPSYLDVLG-- HHHCCCHHHHCCC--	16.82	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NTRK1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NTRK1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NTRK1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TR30A_MOUSE	Trim30a	physical	18598672
SQSTM_MOUSE	Sqstm1	physical	18598672
SQSTM_MOUSE	Sqstm1	physical	21574998
NECD_MOUSE	Ndn	physical	16049186
ULK1_MOUSE	Ulk1	physical	17389358
SQSTM_MOUSE	Sqstm1	physical	17389358
TRAF6_MOUSE	Traf6	physical	17389358

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.