dbPTM

MIER2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MIER2_MOUSE
UniProt AC	Q3U3N0
Protein Name	Mesoderm induction early response protein 2
Gene Name	Mier2
Organism	Mus musculus (Mouse).
Sequence Length	541
Subcellular Localization	Nucleus .
Protein Description	Transcriptional repressor..
Protein Sequence	MAEASSLERQSPRVASCLVHSLCPREPSLQTTAVVSMGSADHQFNLAELLTQNYNLQEGCAEAPQCPDKPEEELDKDFIDQSSDMPLDELLALYGYESSDPISEQESEGGDTAPALPDMTLDKEQIAKDLLSGEEEEETQSSADDLTPSVTSHEASDLFHNQSGSRFLAGDNGPGSSASSDTEEDALPANKCKKEIMVGPQFQADLNILHLNRHCDKIYENEDQLLWSPSVLPEREVEEFLYRAVKRRWQEMAGPQIPEGEVVKDSEQALYELVKCNFNVEEALRRLRFNVKVIRDGLCAWSEEECRNFEHGFRVHGKNFHLIQANKVRTRSVGECVEYYYLWKKSERYDYFAQQTRLGRRKFVSSGTTDTEQDLDGLDPDGHARLHSEAGVPVEPLNVDIEAGGLDQPGVGSDDLPSSEPGPRPFQQLDEPPAVPSLQQPTSLAASAELPPAAAAAPEPGTSPRLPVDLALPEELPLVSSPVALSEDTAEPMAPAQVALSVTEFGLIGIGDVNPFLTGHPACPTSTLHSEPLSQCNVMTC

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MAEASSLERQSP ---CCCCHHHHHCCH	27.28	30635358
6	Phosphorylation	--MAEASSLERQSPR --CCCCHHHHHCCHH	41.10	30635358
11	Phosphorylation	ASSLERQSPRVASCL CHHHHHCCHHHHHHH	22.39	25266776
132	Phosphorylation	QIAKDLLSGEEEEET HHHHHHHCCCHHHHH	52.00	28507225
176	Phosphorylation	AGDNGPGSSASSDTE CCCCCCCCCCCCCCH	26.34	24759943
177	Phosphorylation	GDNGPGSSASSDTEE CCCCCCCCCCCCCHH	37.78	24759943
179	Phosphorylation	NGPGSSASSDTEEDA CCCCCCCCCCCHHHC	30.60	24759943
180	Phosphorylation	GPGSSASSDTEEDAL CCCCCCCCCCHHHCC	48.55	25293948
182	Phosphorylation	GSSASSDTEEDALPA CCCCCCCCHHHCCCH	43.13	25293948

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of MIER2_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MIER2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MIER2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of MIER2_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MIER2_MOUSE

Related Literatures of Post-Translational Modification