CND2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CND2_MOUSE
• UniProt AC: Q8C156
• Protein Name: Condensin complex subunit 2
• Gene Name: Ncaph
• Organism: Mus musculus (Mouse).
• Sequence Length: 731
• Subcellular Localization: Nucleus. Cytoplasm. Chromosome. In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromos
• Protein Description: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (By similarity)..
• Protein Sequence: MRIPRSETMNSSFLKARGQQDVLSSPLERVPPASRPGKAPLGTPKTPVLEDFPQNDDEKERMQRRRSRVFDLQFSTDSIHLASPNRNIDVSTTISKFTNTQITEHYSTCIKLSSENKITTKNAFGLHLIDFMSEILKQKDAEPTNFKVAAGTLDASTKIYAVRVDAVHADVYRVLGGLGKDTPPQGEESHSGDGSTLETERTKKPAKPKKKQSCKTIEQNLSNINVSEADGKCAVDPMFQKTAASFDECSTTGVFLSTLHCQDYRSELLFPSDMQTLSSGEPLELPDLGFVDMTDLEASLQQCVEDRPLCPSLAGFQFTKWDSETHNESVSALVDKFKKNDQVFDINAEAEDDEEDVPDGPLVEDFVDNDEPDLSAAGDHEEFRSWKELCQVQSNQEEVISLEDRDIQVMCSFLSMKPGEYSYFSPRTMKMWAGPDHWRFRPRPKQDATSCTEHKKKSAKKDFEINFDDDIDFDAYFQKTKAATILTKSTLENQNWKATTLPTDFHYETDNLIQLHLKPGKRSLKMDQDQKAKTEHYEEIEDYDYNNPNDTSNYCPGLQAADSDYEEADDLFADPVGTLDLESDPKTTQENGHISPENQGVDITTYQELNLVAEPQKVNKIEIHYAKTAKKMDMKKLKQSMWSLLTKFSRKEADTEANHTESGQEGAPEEVADEKKLSGLTKDLQTRLPPLMAQNLSIPLAFACLLHLANEKNLKLEGTEDLSDVLVMQGD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MRIPRSETMNSSFLK CCCCCHHHCCHHHHH	23.93	29514104
11	Phosphorylation	PRSETMNSSFLKARG CCHHHCCHHHHHHHC	16.19	25266776
12	Phosphorylation	RSETMNSSFLKARGQ CHHHCCHHHHHHHCC	29.60	22942356
24	Phosphorylation	RGQQDVLSSPLERVP HCCCCHHCCCHHCCC	29.74	22942356
25	Phosphorylation	GQQDVLSSPLERVPP CCCCHHCCCHHCCCC	29.37	26824392
43	Phosphorylation	PGKAPLGTPKTPVLE CCCCCCCCCCCCCCC	29.33	27149854
46	Phosphorylation	APLGTPKTPVLEDFP CCCCCCCCCCCCCCC	21.60	26824392
67	Phosphorylation	ERMQRRRSRVFDLQF HHHHHHHHHHHEEEC	30.86	-
75	Phosphorylation	RVFDLQFSTDSIHLA HHHEEECCCCEEEEC	20.53	21149613
76	Phosphorylation	VFDLQFSTDSIHLAS HHEEECCCCEEEECC	34.75	21149613
78	Phosphorylation	DLQFSTDSIHLASPN EEECCCCEEEECCCC	16.40	21149613
83	Phosphorylation	TDSIHLASPNRNIDV CCEEEECCCCCCCEE	29.12	27087446
91	Phosphorylation	PNRNIDVSTTISKFT CCCCCEECCHHHHCC	18.98	28066266
92	Phosphorylation	NRNIDVSTTISKFTN CCCCEECCHHHHCCC	28.18	28066266
93	Phosphorylation	RNIDVSTTISKFTNT CCCEECCHHHHCCCC	18.75	28066266
95	Phosphorylation	IDVSTTISKFTNTQI CEECCHHHHCCCCCC	21.45	28066266
133	Phosphorylation	LHLIDFMSEILKQKD HHHHHHHHHHHHCCC	22.83	29514104
182	Phosphorylation	LGGLGKDTPPQGEES HCCCCCCCCCCCCCC	40.11	21659605
189	Phosphorylation	TPPQGEESHSGDGST CCCCCCCCCCCCCCC	20.74	21149613
191	Phosphorylation	PQGEESHSGDGSTLE CCCCCCCCCCCCCCC	48.10	26824392
195	Phosphorylation	ESHSGDGSTLETERT CCCCCCCCCCCCCCC	34.26	21149613
196	Phosphorylation	SHSGDGSTLETERTK CCCCCCCCCCCCCCC	33.86	21149613
199	Phosphorylation	GDGSTLETERTKKPA CCCCCCCCCCCCCCC	33.60	28066266
222	Phosphorylation	KTIEQNLSNINVSEA HHHHHHHHCCCHHHC	43.12	26745281
227	Phosphorylation	NLSNINVSEADGKCA HHHCCCHHHCCCCEE	23.68	28066266
323	Phosphorylation	FQFTKWDSETHNESV CEEEECCCCCCCHHH	43.19	28066266
325	Phosphorylation	FTKWDSETHNESVSA EEECCCCCCCHHHHH	33.67	28066266
329	Phosphorylation	DSETHNESVSALVDK CCCCCCHHHHHHHHH	27.04	28066266
331	Phosphorylation	ETHNESVSALVDKFK CCCCHHHHHHHHHHH	25.76	28066266
394	Phosphorylation	KELCQVQSNQEEVIS HHHHHCCCCCCCEEE	41.44	25619855
401	Phosphorylation	SNQEEVISLEDRDIQ CCCCCEEECHHHCHH	30.77	25619855
422	Phosphorylation	SMKPGEYSYFSPRTM CCCCCCCCEECCCCC	18.52	26643407
423	Phosphorylation	MKPGEYSYFSPRTMK CCCCCCCEECCCCCC	13.74	26643407
425	Phosphorylation	PGEYSYFSPRTMKMW CCCCCEECCCCCCCC	12.77	26643407
457	Acetylation	SCTEHKKKSAKKDFE CCCHHCHHHCCCCEE	61.52	6566421
479	Acetylation	DFDAYFQKTKAATIL CHHHHHHHHHHEEEE	41.94	6566829
487	Phosphorylation	TKAATILTKSTLENQ HHHEEEECHHHHHCC	21.06	26745281
489	Phosphorylation	AATILTKSTLENQNW HEEEECHHHHHCCCC	32.75	26745281
490	Phosphorylation	ATILTKSTLENQNWK EEEECHHHHHCCCCE	39.38	26745281
523	Phosphorylation	HLKPGKRSLKMDQDQ EECCCCCCCCCCHHH	35.51	25266776
551	Phosphorylation	DYNNPNDTSNYCPGL CCCCCCCCCCCCCCH	26.05	22668510
552	Phosphorylation	YNNPNDTSNYCPGLQ CCCCCCCCCCCCCHH	28.76	22668510
563	Phosphorylation	PGLQAADSDYEEADD CCHHHCCCCHHHHHH	37.05	22668510
565	Phosphorylation	LQAADSDYEEADDLF HHHCCCCHHHHHHHC	21.44	22668510
587	Phosphorylation	DLESDPKTTQENGHI CCCCCCCCCCCCCCC	38.82	26745281
588	Phosphorylation	LESDPKTTQENGHIS CCCCCCCCCCCCCCC	39.76	23984901
595	Phosphorylation	TQENGHISPENQGVD CCCCCCCCCCCCCCC	22.08	21082442
604	Phosphorylation	ENQGVDITTYQELNL CCCCCCCEEEHEECC	18.26	23984901
605	Phosphorylation	NQGVDITTYQELNLV CCCCCCEEEHEECCC	24.44	23984901
606	Phosphorylation	QGVDITTYQELNLVA CCCCCEEEHEECCCC	7.43	23984901
625	Phosphorylation	VNKIEIHYAKTAKKM CCEEEEEEHHHCCCC	18.56	28066266
627	Acetylation	KIEIHYAKTAKKMDM EEEEEEHHHCCCCCH	41.68	-
638	Acetylation	KMDMKKLKQSMWSLL CCCHHHHHHHHHHHH	49.56	22826441
651	Acetylation	LLTKFSRKEADTEAN HHHHHHHHHHCCCCC	56.93	7719707
655	Phosphorylation	FSRKEADTEANHTES HHHHHHCCCCCCCCC	44.01	25266776
660	Phosphorylation	ADTEANHTESGQEGA HCCCCCCCCCCCCCC	31.49	26745281
662	Phosphorylation	TEANHTESGQEGAPE CCCCCCCCCCCCCCH	47.10	27087446
675	Acetylation	PEEVADEKKLSGLTK CHHHCCHHHHCCCCH	60.61	7719717

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CND2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CND2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CND2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PFD2_HUMAN	PFDN2	physical	26496610
SRPK1_HUMAN	SRPK1	physical	26496610
ATPK_HUMAN	ATP5J2	physical	26496610
ESPL1_HUMAN	ESPL1	physical	26496610
CND1_HUMAN	NCAPD2	physical	26496610
SMC4_HUMAN	SMC4	physical	26496610
RCL1_HUMAN	RCL1	physical	26496610
DHRS2_HUMAN	DHRS2	physical	26496610
SMC2_HUMAN	SMC2	physical	26496610
YMEL1_HUMAN	YME1L1	physical	26496610
C1TM_HUMAN	MTHFD1L	physical	26496610
SCLY_HUMAN	SCLY	physical	26496610
NAT10_HUMAN	NAT10	physical	26496610
S39AA_HUMAN	SLC39A10	physical	26496610
CND3_HUMAN	NCAPG	physical	26496610
IN80B_HUMAN	INO80B	physical	26496610
UTP15_HUMAN	UTP15	physical	26496610
MED10_HUMAN	MED10	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.