STRN4_MOUSE - dbPTM
STRN4_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID STRN4_MOUSE
UniProt AC P58404
Protein Name Striatin-4
Gene Name Strn4
Organism Mus musculus (Mouse).
Sequence Length 760
Subcellular Localization Cytoplasm. Membrane
Peripheral membrane protein. Cell projection, dendritic spine. CTTNBP2-binding may regulate dendritic spine distribution..
Protein Description Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein..
Protein Sequence MMEERAAAAVASAASSCRPLGSGTAPNPTAAAPASSPAPGPGPVGKGGGGGGSPGPTAGPEPLSLPGILHFIQHEWARFEAEKARWEAERAELQAQVAFLQGERKGQENLKTDLVRRIKMLEYALKQERAKYHKLKFGTDLNQGEKKTDLSEQVSNGPVESVTLENSPLVWKEGRQLLRQYLEEVGYTDTILDMRSKRVRSLLGRSLELNGAGEPVEGAPRASPGPGGLSGGESLLVKQIEEQIKRNAAGKDGKERLGGSVLEQIPFLQNCEDEDSDEDDELDSVQHKKQRVRLPSKALVPEMEDEDEEDDSEDAINEFDFLGSGEDGEGSPDPRRCTSEGNPHELESRRVKLQGILADLRDVDGLPPKVTVPPPGTPQPRPHEGSFGFSSDVFIMDTIGGGEVSLGDLADLTVTNDNDLSCDLSDSKDAFKKTWNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPVLAVTMGSNSEYCYSGGADARIHSWKIPDLNMDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSGPSCLCTFPMDGEHGIPTSVAFTSTEPAHVVASFRSGDTVLYDLEAGSALLTLESRGSSGPAQINQVVSHPSQPLTITAHDDRGIRFLDNRTGKSVHSMVAHLDAVTCLAVDPNGVFLMSGSHDCSLRLWSLDNKTCVQEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVFV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
16PhosphorylationAVASAASSCRPLGSG
HHHHHHHHCCCCCCC		14.9324453211
17GlutathionylationVASAASSCRPLGSGT
HHHHHHHCCCCCCCC		4.8724333276
35PhosphorylationPTAAAPASSPAPGPG
CCCCCCCCCCCCCCC		35.4829233185
36PhosphorylationTAAAPASSPAPGPGP
CCCCCCCCCCCCCCC		27.4726643407
53PhosphorylationKGGGGGGSPGPTAGP
CCCCCCCCCCCCCCC		29.9226824392
57PhosphorylationGGGSPGPTAGPEPLS
CCCCCCCCCCCCCCC		50.6026745281
64PhosphorylationTAGPEPLSLPGILHF
CCCCCCCCCCCHHHH		43.1425777480
148PhosphorylationLNQGEKKTDLSEQVS
CCCCCCCCCHHHHHH		53.9223984901
151PhosphorylationGEKKTDLSEQVSNGP
CCCCCCHHHHHHCCC		28.8823984901
155PhosphorylationTDLSEQVSNGPVESV
CCHHHHHHCCCCCEE		35.4523984901
161PhosphorylationVSNGPVESVTLENSP
HHCCCCCEEEECCCC		22.1923984901
163PhosphorylationNGPVESVTLENSPLV
CCCCCEEEECCCCCC		37.3223984901
167PhosphorylationESVTLENSPLVWKEG
CEEEECCCCCCHHHH		15.3823984901
201PhosphorylationMRSKRVRSLLGRSLE
HHHHHHHHHHCCCEE		25.7026745281
206PhosphorylationVRSLLGRSLELNGAG
HHHHHCCCEECCCCC		25.1325521595
223PhosphorylationVEGAPRASPGPGGLS
CCCCCCCCCCCCCCC		31.5026824392
230PhosphorylationSPGPGGLSGGESLLV
CCCCCCCCCHHHHHH		48.2928833060
234PhosphorylationGGLSGGESLLVKQIE
CCCCCHHHHHHHHHH		30.2228833060
260PhosphorylationGKERLGGSVLEQIPF
CCHHCCCCHHHHCCC		23.0223984901
276PhosphorylationQNCEDEDSDEDDELD
HCCCCCCCCCCCCHH		40.6327087446
284PhosphorylationDEDDELDSVQHKKQR
CCCCCHHHHHHHHHH		35.9825159016
296PhosphorylationKQRVRLPSKALVPEM
HHHCCCCHHCCCCCC		34.84-
312PhosphorylationDEDEEDDSEDAINEF
CCCCCCCCCHHHHHC		50.0929899451
324PhosphorylationNEFDFLGSGEDGEGS
HHCCCCCCCCCCCCC		40.9525195567
331PhosphorylationSGEDGEGSPDPRRCT
CCCCCCCCCCCCCCC		23.1025338131
377PhosphorylationVTVPPPGTPQPRPHE
CCCCCCCCCCCCCCC		25.2326824392
438UbiquitinationFKKTWNPKFTLRSHY
HHHHCCCCEEEECCC		48.0122790023
440PhosphorylationKTWNPKFTLRSHYDG
HHCCCCEEEECCCCH		27.6427600695
569GlutathionylationTSQRLASCSADGTVR
CHHHHHCCCCCCCEE		3.0224333276
720S-nitrosocysteineWSLDNKTCVQEITAH
EEECCCHHHHHHHHH		2.96-
720S-nitrosylationWSLDNKTCVQEITAH
EEECCCHHHHHHHHH		2.9620925432
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of STRN4_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of STRN4_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of STRN4_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of STRN4_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of STRN4_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations.";
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.;
Mol. Cell. Proteomics 6:283-293(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-206 AND SER-223, ANDMASS SPECTROMETRY.
"Phosphoproteomic analysis of the developing mouse brain.";
Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.;
Mol. Cell. Proteomics 3:1093-1101(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-206, AND MASSSPECTROMETRY.

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