CHMP5_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CHMP5_MOUSE
• UniProt AC: Q9D7S9
• Protein Name: Charged multivesicular body protein 5
• Gene Name: Chmp5
• Organism: Mus musculus (Mouse).
• Sequence Length: 219
• Subcellular Localization: Cytoplasm, cytosol. Endosome membrane; Peripheral membrane protein. Localizes to the midbody of dividing cells. Localized in two distinct rings on either side of the Fleming body (By similarity)..
• Protein Description: Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4 (By similarity)..
• Protein Sequence: MNRFFGKAKPKAPPPSLTDCIGTVDSRAESIDKKISRLDAELVKYKDQIKKMREGPAKNMVKQKALRVLKQKRMYEQQRDNLAQQSFNMEQANYTIQSLKDTKTTVDAMKLGVKEMKKAYKEVKIDQIEDLQDQLEDMMEDANEIQEALGRSYGTPELDEDDLEAELDALGDELLADEDSSYLDEAASAPAIPEGVPTDTKNKDGVLVDEFGLPQIPAS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	Phosphorylation	KPKAPPPSLTDCIGT CCCCCCCCHHHHCCC	50.07	24719451
20	S-nitrosocysteine	PPPSLTDCIGTVDSR CCCCHHHHCCCCHHH	2.32	-
20	Glutathionylation	PPPSLTDCIGTVDSR CCCCHHHHCCCCHHH	2.32	24333276
20	S-nitrosylation	PPPSLTDCIGTVDSR CCCCHHHHCCCCHHH	2.32	22178444
23	Phosphorylation	SLTDCIGTVDSRAES CHHHHCCCCHHHHHH	10.96	26643407
26	Phosphorylation	DCIGTVDSRAESIDK HHCCCCHHHHHHHHH	29.11	26643407
30	Phosphorylation	TVDSRAESIDKKISR CCHHHHHHHHHHHHH	34.79	26643407
44	Acetylation	RLDAELVKYKDQIKK HHHHHHHHHHHHHHH	60.24	22826441
86	Phosphorylation	RDNLAQQSFNMEQAN HHHHHHHHHCHHHHC	13.40	27180971
94	Phosphorylation	FNMEQANYTIQSLKD HCHHHHCHHHHHHHC	14.29	24224561
95	Phosphorylation	NMEQANYTIQSLKDT CHHHHCHHHHHHHCC	16.61	24719451
98	Phosphorylation	QANYTIQSLKDTKTT HHCHHHHHHHCCCHH	33.27	27087446
121	Acetylation	KEMKKAYKEVKIDQI HHHHHHHHHCCHHHH	61.97	6567447
219	Phosphorylation	GLPQIPAS------- CCCCCCCC-------	35.09	25338131

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CHMP5_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CHMP5_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CHMP5_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of CHMP5_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.