CADH4_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CADH4_MOUSE
• UniProt AC: P39038
• Protein Name: Cadherin-4
• Gene Name: Cdh4
• Organism: Mus musculus (Mouse).
• Sequence Length: 913
• Subcellular Localization: Cell membrane; Single-pass type I membrane protein.
• Protein Description: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May play an important role in retinal development..
• Protein Sequence: MTTGSVLPLLLLGLSGALRAHREDLTVREACKAGFSEEGYTALISPNVLEGEKLLKVEFSSCVGTKGMQYETNSLDFKVGADGTVFATRELKIPSEQVAFTVTARERQSAEQWAAMVRLLVAQTSSAHSEHKKGQTVALDPSQPPNDTLLPWPQHQSSGGLRRQKRDWVIPPINVPENSRGPFPQQLVRIRSDKDNDIPIRYSITGVGADQPPMEVFNIDSMSGRMYVTRPMDREERASYHLRAHAVDMNGNKVENPIDLYIYVIDMNDNRPEFINQVYNGSVDEGSKPGTYVMTVTANDADDSTTANGMVRYRIVTQTPQSPSQNMFTINSETGDIVTVAAGLDREKVQQYTVIVQATDMEGNLNYGLSNTATAIITVTDVNDNPPEFTTSTFAGEVPENRIETVVANLTVMDRDQPHSPNWNAVYRIISGDPSGHFSVRTDPVTNEGMVTVVKAVDYELNRAFMLTVMVSNQAPLASGIQMSFQSTAGVTISVTDVNEAPYFPSNHKLIRLEEGVPAGTALTTFSAVDPDRFMQQAVRYSKLSDPANWLHINTSNGQITTAAILDRESLYTKNNVYEATFLAADNGIPPASGTGTLQIYLIDINDNAPQLLPKEAQICERPGLNAINITAADADMDPNIGPYVFELPFIPTTVRKNWTITRLNGDYAQLSLRILYLEAGVYDVPIIVTDSGNPPLSNTSVIKVKVCPCDENGDCTTVGAVAAAGLGTGAIVAILICIVILLIMVLLFVVWMKRREKERHTKQLLIDPEDDVRDNILKYDEEGGGEEDQDYDLSQLQQPEAMEHVLSKTPGVRRVDERPVGAEPQYPVRPVVPHPGDIGDFINEGLRAADNDPTAPPYDSLLVFDYEGSGSTAGSVSSLNSSSSGDQDYDYLNDWGPRFKKLADMYGGGEED

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
26	Phosphorylation	RAHREDLTVREACKA HHHHHCCHHHHHHHC	29.82	-
74	Phosphorylation	GMQYETNSLDFKVGA CCEEEECCCEEEECC	36.41	-
146	N-linked_Glycosylation	LDPSQPPNDTLLPWP CCCCCCCCCCCCCCC	62.68	-
280	N-linked_Glycosylation	EFINQVYNGSVDEGS HHHHHHHCCCCCCCC	37.09	-
282	Phosphorylation	INQVYNGSVDEGSKP HHHHHCCCCCCCCCC	23.82	23375375
359	Phosphorylation	YTVIVQATDMEGNLN EEEEEEEECCCCCCC	20.84	-
367	Phosphorylation	DMEGNLNYGLSNTAT CCCCCCCCCCCCCCE	23.70	-
409	N-linked_Glycosylation	RIETVVANLTVMDRD CEEEEEEECEEECCC	25.32	-
446	Phosphorylation	SVRTDPVTNEGMVTV EEECCCCCCCCCEEE	32.70	28285833
452	Phosphorylation	VTNEGMVTVVKAVDY CCCCCCEEEEEEEEH	15.64	28285833
554	N-linked_Glycosylation	PANWLHINTSNGQIT CCCEEEEECCCCCEE	27.06	-
629	N-linked_Glycosylation	RPGLNAINITAADAD CCCCCEEEEEEECCC	24.13	-
658	N-linked_Glycosylation	IPTTVRKNWTITRLN CCCEECCCEEEEEEC	30.47	-
672	Phosphorylation	NGDYAQLSLRILYLE CCCHHHEEHHHHHHH	11.97	22942356
699	N-linked_Glycosylation	SGNPPLSNTSVIKVK CCCCCCCCCEEEEEE	44.02	-
859	Phosphorylation	NDPTAPPYDSLLVFD CCCCCCCCCEEEEEE	19.66	10502299

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CADH4_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CADH4_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CADH4_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of CADH4_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.