NIN_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NIN_MOUSE
• UniProt AC: Q61043
• Protein Name: Ninein {ECO:0000303|PubMed:8834802}
• Gene Name: Nin {ECO:0000312|MGI:MGI:105108}
• Organism: Mus musculus (Mouse).
• Sequence Length: 2113
• Subcellular Localization: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Component of the core centrosome. Arranged in a tubular conformation with an open and a closed end wi
• Protein Description: Centrosomal protein required for the positioning and anchorage of the microtubule minus-end in epithelial cells. [PubMed: 15784680]
• Protein Sequence: MDEVEEDQHEARLKELFDSFDTLGTGSLGQEELTDLCHVLCLEDVGPVLQQTLLQDNLLGRVHFDQFKEALILILSRTLSSEEHFEESDCSPEAQPKYVRGGKRYGRRSLPEFQESGEEIEEVTVLEPLEEEARSSPIPAGDCGEHWKTQRSEEYEAEGQLRFWNPDDLNASHGGSCPPPDWIEEKLQEVCEDLGITRDGHLNRKKLVSICEQYGLQNVDGAMLEEVFLSLDPDGTMSVEDFFYGLFKTGKSLTPSASTPYRQLKRHLSMQSFDESGRRTATSSAMTSTIGFRVFSCLDDGMGQASVERILDTWQEEGIENSQEILKALDFSLDGNINLTELTLALENELLVTKNGIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRQEREQMLQQVGKQRVELEQEIQKAKTEENYIRDRLALSLKENNRLETELLENAEKLAEYESLTQKLQRSLENVLAEKFGDLDPSSAEFFLQEERLAQMRNEYEQQCRLLQDQVDELQSELEEYQAQGRVLRLPLKNSLSEELDGHSGGIEPDQGPGSEECNPLNMSIEAELVIEQMKEQHHRDLCHLRLELEDKVRHYEKQLDDTRVASEQEQAAMKQKYEQGVHTLEKRVSELRSEIADLEGQAAVLREAHHKASCRHEEEKRQLQMAFDEEKAQLQEELRQEHERELQARLQQAAESFRQEREGLAQAAWTEEKVRGLEQSYQEQLLSLEEKHALEKEELREELSEHHRRELQEGREEMETECNRRVSQIEAQCQADCEKVTEHCEQTLQSLEVRHRQELRDLLDQHLEERSQWEFEKDELTQECTDAQEQLKEALQRERATAAAMKQEQEILERTYKDRLNILSTERKQLLQDLKDLQNASESQHGLLSGQILELKRSQERELRDQGQALCQTGVSEQLASQQLERLRVEHEQERREMTGKLAALESAHRASLERADQEKAEMSTEICRLQNTVKDMQQAASLLMLQGGCQATAGEEAEGDGAMSLLQQGEQLLEENGDVLISLQRAHEHAVKENAKMATEISRLQQRLKKLEPGSVISSCLEEGTSEISGSSREQVEPIMKQGPATKHFLSDLGDHEARDLASTGTSSVQRQECKTEASEASLDCFSELENSEDTRTESWDLKSQISQLREQLTVLRADCDRASERKQDLLFDISVLKKKLKMLERLPEASSRYKVLYEDAARENSCLQEELRLVETRYEESLDSNKELTAEVYRLQDEMKKMEEVMETFLSLEKSYDEVKVENEELRALVLRLQGKMEKVLGRAALQGDSYALWEAPSENLEVASDEKMLELRQTPKECTPKVVSMHHIIEECTQETQCCEQGSTKLLARIKAHEIAWFHRAIKTHPEKPSAQNRVIPEGSAALLGLQDKHLQQEATIAELELEKQKLQELTRNLRERVTALVRQKDAPSQGQKEEELKAMMQDLQITCGEMQRKVELLRYESEKLQEENSILRNEITTLNEEDSISNLKLEELNGSQEELWQKIETIEQEKASIQTMVEKLKKQVSDLKIKNQQLDSENIELSQKNSQNKEELKTLNQRLAEMLCQREEPGACTSEKWEQENASLKEELDHYKVQTSTLVSSLEAELSEVKLQTHVMEQENLLLKDELERLKQLHRCPDLSDFQQKMSSILSYNEKLLKEKEVLSEELKSCADKLAESSLLEHRIATMKQEQTAWEEQSESLKSQLAVSQAKVQNLEDVLQNVNLQMAEIESDLQVTRQEKEALKQEVMSLHRQLQNAIDKDWVSETAPHLSGLRGQQRRLSWDKLDHLMNEEPQLLCQESKRLQTVVQNTQADLTHSREKVRQLESNLLPTKHQKQLNQPCTVKSTEQEKLTLKRECEQSQKEQSPTSRKVGQMGSLERGLETIHLENEGLKKKQMQPLRSTVTRSPSSHWDLQLLQQQACPMVPREQFLQLQQQLLQAEKRSQHLQEELENRTSETNTPQGNQEHLVNLMEERMIEVEQKLKLVKRLLQEKVNQLKEQLCKNTKTDAVVKDLYVENAQLLKALEMTEQRQKTAEKRNFLLEEKIASLSTIVRNLAPAPLTSMPPLRS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
80	Phosphorylation	LILSRTLSSEEHFEE HHHHCCCCCHHHHCC	34.78	30635358
81	Phosphorylation	ILSRTLSSEEHFEES HHHCCCCCHHHHCCC	50.55	30635358
88	Phosphorylation	SEEHFEESDCSPEAQ CHHHHCCCCCCCCCC	36.40	30635358
91	Phosphorylation	HFEESDCSPEAQPKY HHCCCCCCCCCCCCC	30.66	30635358
135	Phosphorylation	PLEEEARSSPIPAGD CCCHHHHCCCCCCCC	47.73	28418008
136	Phosphorylation	LEEEARSSPIPAGDC CCHHHHCCCCCCCCC	22.69	22942356
149	Phosphorylation	DCGEHWKTQRSEEYE CCCHHCCCCCCHHHH	24.83	28833060
152	Phosphorylation	EHWKTQRSEEYEAEG HHCCCCCCHHHHCCC	25.59	28833060
155	Phosphorylation	KTQRSEEYEAEGQLR CCCCCHHHHCCCCCC	19.18	24759943
252	Phosphorylation	GLFKTGKSLTPSAST HHHHCCCCCCCCCCC	38.53	29176673
254	Phosphorylation	FKTGKSLTPSASTPY HHCCCCCCCCCCCHH	23.45	22942356
256	Phosphorylation	TGKSLTPSASTPYRQ CCCCCCCCCCCHHHH	29.62	29176673
261	Phosphorylation	TPSASTPYRQLKRHL CCCCCCHHHHHHHHH	15.87	24759943
269	Phosphorylation	RQLKRHLSMQSFDES HHHHHHHHCCCCCCC	14.51	25266776
272	Phosphorylation	KRHLSMQSFDESGRR HHHHHCCCCCCCCCC	26.48	25367039
343	Phosphorylation	NINLTELTLALENEL CCCHHHHHHHHHCCE	12.07	26239621
353	Phosphorylation	LENELLVTKNGIHQA HHCCEEEECCCHHHH	20.82	26239621
540	Phosphorylation	LAQMRNEYEQQCRLL HHHHHHHHHHHHHHH	23.68	-
670	Phosphorylation	HTLEKRVSELRSEIA HHHHHHHHHHHHHHH	34.64	27149854
1133	Phosphorylation	PATKHFLSDLGDHEA HHHHHHHHHCCCHHH	29.82	27600695
1150	Phosphorylation	LASTGTSSVQRQECK HHHCCCHHHHHHHHH	23.31	27566939
1186	Phosphorylation	TESWDLKSQISQLRE HHCCCHHHHHHHHHH	39.79	23737553
1189	Phosphorylation	WDLKSQISQLREQLT CCHHHHHHHHHHHHH	18.61	23737553
1455	Phosphorylation	KQKLQELTRNLRERV HHHHHHHHHHHHHHH	19.43	24719451
1473	Phosphorylation	VRQKDAPSQGQKEEE HHCCCCCCCCCCHHH	48.98	29514104
1521	Phosphorylation	SILRNEITTLNEEDS CHHHCCCCCCCCCCC	21.03	29472430
1522	Phosphorylation	ILRNEITTLNEEDSI HHHCCCCCCCCCCCC	32.99	29472430
1528	Phosphorylation	TTLNEEDSISNLKLE CCCCCCCCCHHCCHH	31.06	27180971
1530	Phosphorylation	LNEEDSISNLKLEEL CCCCCCCHHCCHHHH	39.81	29472430
1540	Phosphorylation	KLEELNGSQEELWQK CHHHHCCCHHHHHHH	33.09	27180971
1557	Phosphorylation	TIEQEKASIQTMVEK HHHHHHHHHHHHHHH	26.71	30482847
1560	Phosphorylation	QEKASIQTMVEKLKK HHHHHHHHHHHHHHH	22.86	30482847
1745	Phosphorylation	AWEEQSESLKSQLAV HHHHHHHHHHHHHHH	46.47	23140645
1748	Phosphorylation	EQSESLKSQLAVSQA HHHHHHHHHHHHHHH	35.40	-
1753	Phosphorylation	LKSQLAVSQAKVQNL HHHHHHHHHHHHCCH	20.86	-
1826	Phosphorylation	RGQQRRLSWDKLDHL CCCHHCCCHHHHHHH	31.27	25266776
1921	Phosphorylation	RKVGQMGSLERGLET CCHHHCHHHHHHHCH	23.01	22802335
1954	Phosphorylation	TVTRSPSSHWDLQLL CCCCCCCCHHHHHHH	36.64	24719451
1963	Phosphorylation	WDLQLLQQQACPMVP HHHHHHHHHCCCCCC	31.79	24759943
2059	Phosphorylation	DAVVKDLYVENAQLL CHHHHHHHHHHHHHH		25159016

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NIN_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NIN_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NIN_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of NIN_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.