CYS1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CYS1_MOUSE
• UniProt AC: Q8R4T1
• Protein Name: Cystin-1
• Gene Name: Cys1
• Organism: Mus musculus (Mouse).
• Sequence Length: 145
• Subcellular Localization: Cell projection, cilium membrane; Lipid-anchor. Cytoplasm, cytoskeleton, cilium axoneme. Localization to cilium is mediated via interaction with UNC119 and UNC119B, which bind to the myristoyl moiety of the N-terminus (By similarity). Expression is e
• Protein Sequence: MGSGSSRSGRIPRRRRSPDRRQTGPGETASEGGTADQAPTAAGQEESGRDPRPATPSGGREETLRLLDQLLAESEAWGPQELTPRGPARLAPAVSPEKKVKGNPEDSCASEAPGNSPKRPEGQSAISYDYSEEELMASIEREYCR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	N-myristoyl glycine	------MGSGSSRSG ------CCCCCCCCC	40.49	-
2	Myristoylation	------MGSGSSRSG ------CCCCCCCCC	40.49	19850956
47	Phosphorylation	TAAGQEESGRDPRPA CHHCCCCCCCCCCCC	38.07	23140645
55	Phosphorylation	GRDPRPATPSGGREE CCCCCCCCCCCCHHH	22.22	22817900
95	Phosphorylation	ARLAPAVSPEKKVKG CCCCCCCCCCCCCCC	29.46	26824392
110	Phosphorylation	NPEDSCASEAPGNSP CHHHCCCCCCCCCCC	38.32	27742792
116	Phosphorylation	ASEAPGNSPKRPEGQ CCCCCCCCCCCCCCC	37.40	25521595
130	Phosphorylation	QSAISYDYSEEELMA CCCCCCCCCHHHHHH	15.11	29899451
131	Phosphorylation	SAISYDYSEEELMAS CCCCCCCCHHHHHHH	35.32	29899451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CYS1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CYS1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CYS1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NECD_MOUSE	Ndn	physical	24349431

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Myristoylation

"Cystin localizes to primary cilia via membrane microdomains and atargeting motif.";
Tao B., Bu S., Yang Z., Siroky B., Kappes J.C., Kispert A.,Guay-Woodford L.M.;
J. Am. Soc. Nephrol. 20:2570-2580(2009).
Cited for: SUBCELLULAR LOCATION, CILIARY TARGETING MOTIF, AND MYRISTOYLATION ATGLY-2.
PubMed: 19850956