TYW1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TYW1_MOUSE
• UniProt AC: Q8BJM7
• Protein Name: S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase
• Gene Name: Tyw1
• Organism: Mus musculus (Mouse).
• Sequence Length: 721
• Protein Description: Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis (By similarity)..
• Protein Sequence: MGPLDVWDLSPLLSLWMNRFYIYMGCALGLTLCICVQIIKKQVTRSQEKRVPGAPDSSLSPQKKQTHVSGVKIFYGSQTGTAKGFAVVLAKAVTSLDLPVAIINLKEYDPDDSLIGEITSKTVCAFLVATYTDGCPTESAEWFCKWLEESANDFRFGKTYLKGLRYAVFGLGDSAYRSHFNKVSTNVDKWLWMLGAQRVLTRGEGDCNAVQSKHGSIEADFTAWKTKFISRLQALQRGEKKACGGNCKRGKCESAQHGPGEARPHPQGELHPGDAEEEEPCESSSEDELGTQDYQSLTSVVDVEDLGNIMNPVKREKREKSHQDGKAAMQRNPEKTEDGEGRAMITPALREALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGTEWRWKMDQPELILKEAIENHQNMIKQFKGVPGLKAERFEEGMEVKHCALSLVGEPIMYPEINRLLKLLHQHGISSFLVTNAQFPEEIRKLTPVTQLYVSVDASTRDGLKKIDRPLFKDFWQRFLDSLKALSAKQQRTVYRLTLVKCWNVDELQAYAELVSLGNPDFIEVKGVTYCGESAASSLTMANVPWHEEVVRFVRELVDLLPDYEVACEHEHSNCLLIGHKKFKIDGEWWTWINYSRFQELVLQYEESGGSKTFSSRDYMARTPQWALFGARERGFDPKDTRYQRKNKTKDISGC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21	Phosphorylation	SLWMNRFYIYMGCAL HHHHHHHHHHHHHHH	6.47	29895711
23	Phosphorylation	WMNRFYIYMGCALGL HHHHHHHHHHHHHHH	3.98	29895711
31	Phosphorylation	MGCALGLTLCICVQI HHHHHHHHHHHHHHH	20.13	29895711
57	Phosphorylation	RVPGAPDSSLSPQKK CCCCCCCCCCCCCCC	31.92	27600695
58	Phosphorylation	VPGAPDSSLSPQKKQ CCCCCCCCCCCCCCC	40.00	28066266
60	Phosphorylation	GAPDSSLSPQKKQTH CCCCCCCCCCCCCCC	27.51	25159016
159	Phosphorylation	NDFRFGKTYLKGLRY CCCCCCHHHHHHHHH	34.17	24719451
385	Acetylation	RGRGGCYKHTFYGIE CCCCCCHHHCCCEEC	40.00	22826441

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TYW1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TYW1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TYW1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of TYW1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.