RN114_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RN114_MOUSE
• UniProt AC: Q9ET26
• Protein Name: E3 ubiquitin-protein ligase RNF114
• Gene Name: Rnf114
• Organism: Mus musculus (Mouse).
• Sequence Length: 229
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: E3 ubiquitin-protein ligase promoting the ubiquitination and degradation of the CDK inhibitor CDKN1A and probably also CDKN1B and CDKN1C. These activities stimulate cell cycle's G1-to-S phase transition and suppress cellular senescence. May play a role in spermatogenesis..
• Protein Sequence: MAAAQPESRDGAAQSAKPASETDPLSRFTCPVCLEVFEKPVQVPCGHVFCSACLQECLKPKKPVCGVCRSALAPGVRAVELERQIESIETSCHGCRKNFILSKIRAHVTSCSKYQNYIMEGVKATTKDASLQPRNIPNRYTFPCPYCPEKNFDQEGLVEHCKLTHSTDTKSVVCPICASMPWGDPSYRSANFMEHIQRRHRFSYDTFVDYDVDEDDMINQVLQRSIIDQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	Ubiquitination	DGAAQSAKPASETDP CCCCCCCCCCCCCCC	46.49	27667366
61	Ubiquitination	LQECLKPKKPVCGVC HHHHHCCCCCCCHHH	69.03	-
62	Ubiquitination	QECLKPKKPVCGVCR HHHHCCCCCCCHHHH	51.73	-
62	Malonylation	QECLKPKKPVCGVCR HHHHCCCCCCCHHHH	51.73	32601280
65	Glutathionylation	LKPKKPVCGVCRSAL HCCCCCCCHHHHHHC	4.60	24333276
97	Ubiquitination	TSCHGCRKNFILSKI HHHCHHHHHHHHHHH	61.35	-
97	Malonylation	TSCHGCRKNFILSKI HHHCHHHHHHHHHHH	61.35	26320211
103	Acetylation	RKNFILSKIRAHVTS HHHHHHHHHHHHHHH	32.53	-
103	Ubiquitination	RKNFILSKIRAHVTS HHHHHHHHHHHHHHH	32.53	-
113	Acetylation	AHVTSCSKYQNYIME HHHHHHHHHHHHHHH	56.00	-
117	Phosphorylation	SCSKYQNYIMEGVKA HHHHHHHHHHHHHHE	6.01	29514104
123	Ubiquitination	NYIMEGVKATTKDAS HHHHHHHHEECCCCC	51.37	27667366
127	Ubiquitination	EGVKATTKDASLQPR HHHHEECCCCCCCCC	47.12	27667366
161	S-nitrosylation	QEGLVEHCKLTHSTD CCCHHHHHCCCCCCC	2.15	21278135
161	S-nitrosocysteine	QEGLVEHCKLTHSTD CCCHHHHHCCCCCCC	2.15	-
162	Ubiquitination	EGLVEHCKLTHSTDT CCHHHHHCCCCCCCC	59.33	-
187	Phosphorylation	MPWGDPSYRSANFME CCCCCCCHHCHHHHH	17.61	-
189	Phosphorylation	WGDPSYRSANFMEHI CCCCCHHCHHHHHHH	21.23	28066266

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RN114_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RN114_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RN114_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of RN114_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.