ITB5_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ITB5_MOUSE
• UniProt AC: O70309
• Protein Name: Integrin beta-5
• Gene Name: Itgb5
• Organism: Mus musculus (Mouse).
• Sequence Length: 798
• Subcellular Localization: Membrane; Single-pass type I membrane protein.
• Protein Description: Integrin alpha-V/beta-5 (ITGAV:ITGB5) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand..
• Protein Sequence: MPRVPATLYACLLGLCALVPRLAGLNICTSGSATSCEECLLIHPKCAWCSKEYFGNPRSITSRCDLKANLIRNGCEGEIESPASSTHVLRNLPLSSKGSSATGSDVIQMTPQEIAVSLRPGEQTTFQLQVRQVEDYPVDLYYLMDLSLSMKDDLENIRSLGTKLAEEMRKLTSNFRLGFGSFVDKDISPFSYTAPRYQTNPCIGYKLFPNCVPSFGFRHLLPLTDRVDSFNEEVRKQRVSRNRDAPEGGFDAVLQAAVCKEKIGWRKDALHLLVFTTDDVPHIALDGKLGGLVQPHDGQCHLNEANEYTASNQMDYPSLALLGEKLAENNINLIFAVTKNHYMLYKNFTALIPGTTVEILHGDSKNIIQLIINAYSSIRAKVELSVWDQPEDLNLFFTATCQDGISYPGQRKCEGLKIGDTASFEVSVEARSCPGRQAAQSFTLRPVGFRDSLQVEVAYNCTCGCSTGLEPNSARCSGNGTYTCGLCECDPGYLGTRCECQEGENQSGYQNLCREAEGKPLCSGRGECSCNQCSCFESEFGRIYGPFCECDSFSCARNKGVLCSGHGECHCGECKCHAGYIGDNCNCSTDVSTCKAKDGQICSDRGRCVCGQCQCTEPGAFGETCEKCPTCPDACSSKRDCVECLLLHQGKPDNQTCHHQCKDEVITWVDTIVKDDQEAVLCFYKTAKDCVMMFSYTELPNGRSNLTVLREPECGSAPNAMTILLAVVGSILLIGMALLAIWKLLVTIHDRREFAKFQSERSRARYEMASNPLYRKPISTHTVDFAFNKFNKSYNGSV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
110	Phosphorylation	GSDVIQMTPQEIAVS CCCCEECCCCEEEEE	12.87	26026062
117	Phosphorylation	TPQEIAVSLRPGEQT CCCEEEEEECCCCCE	15.05	26026062
124	Phosphorylation	SLRPGEQTTFQLQVR EECCCCCEEEEEEEE	25.85	26026062
125	Phosphorylation	LRPGEQTTFQLQVRQ ECCCCCEEEEEEEEE	14.74	26026062
149	Phosphorylation	YLMDLSLSMKDDLEN EEEECCCCCHHHHHH	22.02	22802335
347	N-linked_Glycosylation	NHYMLYKNFTALIPG CCEEEECCEEEECCC	26.41	-
460	N-linked_Glycosylation	LQVEVAYNCTCGCST EEEEEEEECCCCCCC	12.60	-
479	N-linked_Glycosylation	NSARCSGNGTYTCGL CCCEECCCCCEEECE	24.28	-
505	N-linked_Glycosylation	CECQEGENQSGYQNL EEECCCCCCCHHHHH	52.77	-
586	N-linked_Glycosylation	GYIGDNCNCSTDVST EECCCCCCCCCCHHH	29.09	-
654	N-linked_Glycosylation	LHQGKPDNQTCHHQC HCCCCCCCCCCCHHH	47.81	-
705	N-linked_Glycosylation	ELPNGRSNLTVLREP ECCCCCCCEEEEECC	38.07	-
759	Phosphorylation	REFAKFQSERSRARY HHHHHHHHHHHHHHH	37.80	24719451
770	Phosphorylation	RARYEMASNPLYRKP HHHHHHHCCCCCCCC	37.36	26824392
774	Phosphorylation	EMASNPLYRKPISTH HHHCCCCCCCCCCHH	20.18	29514104
779	Phosphorylation	PLYRKPISTHTVDFA CCCCCCCCHHHHEEC	23.74	26824392
780	Phosphorylation	LYRKPISTHTVDFAF CCCCCCCHHHHEECC	23.45	27087446
782	Phosphorylation	RKPISTHTVDFAFNK CCCCCHHHHEECCCC	23.12	27087446

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ITB5_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ITB5_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ITB5_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MK01_MOUSE	Mapk1	physical	11857080

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.