HIP1R_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HIP1R_MOUSE
• UniProt AC: Q9JKY5
• Protein Name: Huntingtin-interacting protein 1-related protein
• Gene Name: Hip1r
• Organism: Mus musculus (Mouse).
• Sequence Length: 1068
• Subcellular Localization: Cytoplasm, perinuclear region. Endomembrane system. Cytoplasmic vesicle, clathrin-coated vesicle membrane. Membrane-associated protein, mainly localized at the endocytic compartments and in the perinuclear region.
• Protein Description: Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis..
• Protein Sequence: MNSIKNVPARVLSRRPGHSLEAEREQFDKTQAISISKAINSQEAPVKEKHARRIILGTHHEKGAFTFWSYAIGLPLSSSSILSWKFCHVLHKVLRDGHPNVLHDYQRYRSNIREIGDLWGHLRDQYGHLVNIYTKLLLTKISFHLKHPQFPAGLEVTDEVLEKAAGTDVNNIFQLTVEMFDYMDCELKLSESVFRQLNTAIAVSQMSSGQCRLAPLIQVIQDCSHLYHYTVKLMFKLHSCLPADTLQGHRDRFHEQFHSLKNFFRRASDMLYFKRLIQIPRLPEGPPNFLRASALAEHIKPVVVIPEEAPEEEEPENLIEISSAPPAGEPVVVADLFDQTFGPPNGSMKDDRDLQIENLKREVETLRAELEKIKMEAQRYISQLKGQVNGLEAELEEQRKQKQKALVDNEQLRHELAQLKALQLEGARNQGLREEAERKASATEARYSKLKEKHSELINTHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQMEQAKRESEMKMEEQSDQLEKLKRELAARAGELARAQEALSRTEQSGSELSSRLDTLNAEKEALSGVVRQREAELLAAQSLVREKEEALSQEQQRSSQEKGELRGQLAEKESQEQGLRQKLLDEQLAVLRSAAAEAEAILQDAVSKLDDPLHLRCTSSPDYLVSRAQAALDSVSGLEQGHTQYLASSEDASALVAALTRFSHLAADTIVNGAATSHLAPTDPADRLMDTCRECGARALELVGQLQDQTVLPRAQPSLMRAPLQGILQLGQDLKPKSLDVRQEELGAMVDKEMAATSAAIEDAVRRIEDMMSQARHESSGVKLEVNERILNSCTDLMKAIRLLVMTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVESADKVVLHMGKYEELIVCSHEIAASTAQLVAASKVKANKNSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERVRLGELRKQHYVLAGGMGTPSEEEPSRPSPAPRSGATKKPPLAQKPSIAPRTDNQLDKKDGVYPAQLVNY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MNSIKNVP -------CCCCCCCC	39.71	-
3	Phosphorylation	-----MNSIKNVPAR -----CCCCCCCCHH	46.96	24759943
5	Ubiquitination	---MNSIKNVPARVL ---CCCCCCCCHHHH	52.27	-
19	Phosphorylation	LSRRPGHSLEAEREQ HCCCCCCCHHHHHHH	33.54	26643407
29	Ubiquitination	AEREQFDKTQAISIS HHHHHCCHHHHHHHH	43.77	27667366
34	Phosphorylation	FDKTQAISISKAINS CCHHHHHHHHHHHCC	24.67	22817900
37	Ubiquitination	TQAISISKAINSQEA HHHHHHHHHHCCCCC	52.17	27667366
92	Ubiquitination	KFCHVLHKVLRDGHP HHHHHHHHHHHCCCC	38.51	-
126	Phosphorylation	WGHLRDQYGHLVNIY HHHHHHHHHHHHHHH	15.71	29514104
133	Phosphorylation	YGHLVNIYTKLLLTK HHHHHHHHHHHHHHH	7.82	29514104
134	Phosphorylation	GHLVNIYTKLLLTKI HHHHHHHHHHHHHHH	16.06	29514104
146	Ubiquitination	TKISFHLKHPQFPAG HHHHHHCCCCCCCCC	44.67	-
293	Phosphorylation	PPNFLRASALAEHIK CCCCHHHHHHHHHCC	19.85	29472430
455	Phosphorylation	SKLKEKHSELINTHA HHHHHHHHHHHHHHH	45.20	30165576
460	Phosphorylation	KHSELINTHAELLRK HHHHHHHHHHHHHHH	18.57	30165576
481	Phosphorylation	QLTVTQQSQEEVARV HHEECHHHHHHHHHH	29.73	25521595
652	Phosphorylation	PLHLRCTSSPDYLVS CCCCCCCCCHHHHHH	43.42	29472430
653	Phosphorylation	LHLRCTSSPDYLVSR CCCCCCCCHHHHHHH	12.02	29472430
656	Phosphorylation	RCTSSPDYLVSRAQA CCCCCHHHHHHHHHH	16.64	29472430
659	Phosphorylation	SSPDYLVSRAQAALD CCHHHHHHHHHHHHH	21.21	27818261
1045	Phosphorylation	PPLAQKPSIAPRTDN CCCCCCCCCCCCCCC	38.12	25266776

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HIP1R_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HIP1R_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HIP1R_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of HIP1R_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.