HMHA1_MOUSE - dbPTM
HMHA1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID HMHA1_MOUSE
UniProt AC Q3TBD2
Protein Name Rho GTPase-activating protein 45 {ECO:0000312|MGI:MGI:1917969}
Gene Name Arhgap45 {ECO:0000312|MGI:MGI:1917969}
Organism Mus musculus (Mouse).
Sequence Length 1116
Subcellular Localization Cytoplasm . Cell projection, ruffle membrane .
Protein Description Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR-domin which is able to play an autoinhibitory effect on this RhoGAP activity..
Protein Sequence MFSRKKRELMKTPSISKKNRAGSPNPQSSSGELPRKDWTEAPGLEPPATSLSTVAKGTGTLKRPTSLSRHASAAGFPLSGTATWTLVRGYRSPLSAASPAELPTEGAFPDGVEDISTLLADVARFAEGLEKLKECVLQDDLLEARRPLAHECLGEALRVMRQVISRYPLLNTVETLTAAGTLIAKVKAFHYECNNESDKREFEKALETIAVSFSCTVSEFLLGEVDSSTLLAVPPGDPSQSMENLYGAGTEGPPHNVEECEEGCLPPEEVDMLLQRCEGGVDAALQYAKDMARYMKDLISYLEKRTTLEMEFAKGLQKVVHNCRQSVTHEPHMPLLSIYSLALEQDLEFGHGMVQAAGTLQTQTFMQPLTLRRLEHERRRKEIKESWHRAQRKLQEAEANLRKAKQGYKQRCEDHDKARLQVAKAEEEQQGTGPGAGTAASKALDKRRRLEEEAKNKAEEAMATYRTCVADAKTQKQELEDTKVTALRQIQEVIRQSDQTIKSATISYYQLMHMQTAPLPVNFQMLCESSKLYDPGQQYASHVRQLQRGEEPDVRYDFEPYVSNNSWSPIMRTRKGSFNPGDASGPEAAGSPPEEGGTSEAAPNKDHRGGRGHQVHKSWPISISDTEVGLDTSSGDLKKFDRTSSSGTMSSSEELGDQEAGLVASAFDSADLNGMDPELPVAMPSGPFRHVGLSKAARTHRLRKLRTPAKCRECNSYVYFQGAECEECCLACHKKCLETLAIQCGHKKLQGRLQLFGQDFSQAALSTPDGVPFIVKKCVCEIERRALHTKGIYRVNGVKTRVEKLCQAFENGKELVELSQASPHDISNVLKLYLRQLPEPLISFRFYHELVGLAKDSLKAEAEAKAASRGRQGGSESEAATLAMVGRLRELMQDLPAENRATLLYLLKHLRRIVEMEQDNKMTPGNLGIVFGPTLLRPRPTDATVSLSSLVDYPHQARVIETLIVHYGLVFEEEPEEAPGSQEGASTQCGQLESAEGIVFPLQEEAEDGSRESHAASNDSDSELEDASDPLSSSDASALHRLSFLEQTEAGLEEGPQSHSGSEEQLEGEDGAPGPWLCHFNTNQSNNTSRAPLPTMRLRGGQITGGTSQERQPQFV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
12PhosphorylationKKRELMKTPSISKKN
HHHHHHCCCCCCCCC		14.3328833060
14PhosphorylationRELMKTPSISKKNRA
HHHHCCCCCCCCCCC		44.7328833060
16PhosphorylationLMKTPSISKKNRAGS
HHCCCCCCCCCCCCC		41.7528833060
23PhosphorylationSKKNRAGSPNPQSSS
CCCCCCCCCCCCCCC		22.1026824392
28PhosphorylationAGSPNPQSSSGELPR
CCCCCCCCCCCCCCC		27.9428833060
29PhosphorylationGSPNPQSSSGELPRK
CCCCCCCCCCCCCCC		36.8028833060
30PhosphorylationSPNPQSSSGELPRKD
CCCCCCCCCCCCCCC		41.3528833060
39PhosphorylationELPRKDWTEAPGLEP
CCCCCCCCCCCCCCC		32.1925367039
60PhosphorylationTVAKGTGTLKRPTSL
HHHCCCCCCCCCCCC		29.0129176673
65PhosphorylationTGTLKRPTSLSRHAS
CCCCCCCCCCCCCHH		46.4629472430
66PhosphorylationGTLKRPTSLSRHASA
CCCCCCCCCCCCHHH		27.3424704852
68PhosphorylationLKRPTSLSRHASAAG
CCCCCCCCCCHHHCC		23.0624719451
72PhosphorylationTSLSRHASAAGFPLS
CCCCCCHHHCCCCCC		16.7222817900
88MethylationTATWTLVRGYRSPLS
CEEEEEECCCCCCCC		39.2757714807
90PhosphorylationTWTLVRGYRSPLSAA
EEEEECCCCCCCCCC		9.4323984901
92PhosphorylationTLVRGYRSPLSAASP
EEECCCCCCCCCCCC		23.0027180971
95PhosphorylationRGYRSPLSAASPAEL
CCCCCCCCCCCCCCC		25.7726745281
98PhosphorylationRSPLSAASPAELPTE
CCCCCCCCCCCCCCC		25.1025266776
104PhosphorylationASPAELPTEGAFPDG
CCCCCCCCCCCCCCC		60.7323984901
300PhosphorylationRYMKDLISYLEKRTT
HHHHHHHHHHHHHCC		30.84-
465PhosphorylationAEEAMATYRTCVADA
HHHHHHHHHHHHHCH		8.39-
561PhosphorylationVRYDFEPYVSNNSWS
CCCCCCCCCCCCCCC		14.8728833060
563PhosphorylationYDFEPYVSNNSWSPI
CCCCCCCCCCCCCCC		25.1728833060
566PhosphorylationEPYVSNNSWSPIMRT
CCCCCCCCCCCCCCC		32.9328833060
568PhosphorylationYVSNNSWSPIMRTRK
CCCCCCCCCCCCCCC		12.3626824392
573PhosphorylationSWSPIMRTRKGSFNP
CCCCCCCCCCCCCCC		21.2520531401
577PhosphorylationIMRTRKGSFNPGDAS
CCCCCCCCCCCCCCC		25.5325521595
584PhosphorylationSFNPGDASGPEAAGS
CCCCCCCCCCCCCCC		60.6723375375
591PhosphorylationSGPEAAGSPPEEGGT
CCCCCCCCCCCCCCC		32.3322942356
598PhosphorylationSPPEEGGTSEAAPNK
CCCCCCCCCCCCCCC		33.9628833060
599PhosphorylationPPEEGGTSEAAPNKD
CCCCCCCCCCCCCCC		28.6328833060
618PhosphorylationRGHQVHKSWPISISD
CCCCCCCCCCCCCCC		24.1728725479
622PhosphorylationVHKSWPISISDTEVG
CCCCCCCCCCCCEEE		16.3826745281
624PhosphorylationKSWPISISDTEVGLD
CCCCCCCCCCEEEEC		31.5225266776
626PhosphorylationWPISISDTEVGLDTS
CCCCCCCCEEEECCC		26.2726745281
632PhosphorylationDTEVGLDTSSGDLKK
CCEEEECCCCCCCCC		29.8126745281
633PhosphorylationTEVGLDTSSGDLKKF
CEEEECCCCCCCCCC		31.8026745281
634PhosphorylationEVGLDTSSGDLKKFD
EEEECCCCCCCCCCC		38.1226745281
875PhosphorylationSRGRQGGSESEAATL
HCCCCCCCHHHHHHH		44.7822942356
877PhosphorylationGRQGGSESEAATLAM
CCCCCCHHHHHHHHH		33.9428833060
881PhosphorylationGSESEAATLAMVGRL
CCHHHHHHHHHHHHH		23.3028285833
923PhosphorylationMEQDNKMTPGNLGIV
HHHCCCCCCCCCEEE		29.6523984901
934PhosphorylationLGIVFGPTLLRPRPT
CEEEECCCCCCCCCC		38.5123984901
941PhosphorylationTLLRPRPTDATVSLS
CCCCCCCCCCEEEHH		39.2723984901
944PhosphorylationRPRPTDATVSLSSLV
CCCCCCCEEEHHHHC		17.2823984901
946PhosphorylationRPTDATVSLSSLVDY
CCCCCEEEHHHHCCC		20.4119060867
948PhosphorylationTDATVSLSSLVDYPH
CCCEEEHHHHCCCHH		17.7025266776
949PhosphorylationDATVSLSSLVDYPHQ
CCEEEHHHHCCCHHH		37.3919060867
953PhosphorylationSLSSLVDYPHQARVI
EHHHHCCCHHHHHHH		8.6423984901
1013PhosphorylationAEDGSRESHAASNDS
CCCCCCCCCCCCCCC		19.8124704852
1017PhosphorylationSRESHAASNDSDSEL
CCCCCCCCCCCCHHH		41.7921082442
1020PhosphorylationSHAASNDSDSELEDA
CCCCCCCCCHHHHHC		47.4921082442
1022PhosphorylationAASNDSDSELEDASD
CCCCCCCHHHHHCCC		48.2922942356
1028PhosphorylationDSELEDASDPLSSSD
CHHHHHCCCCCCCCC		52.6725159016
1032PhosphorylationEDASDPLSSSDASAL
HHCCCCCCCCCHHHH		32.9325159016
1033PhosphorylationDASDPLSSSDASALH
HCCCCCCCCCHHHHH		39.6625159016
1034PhosphorylationASDPLSSSDASALHR
CCCCCCCCCHHHHHH		33.5425159016
1037PhosphorylationPLSSSDASALHRLSF
CCCCCCHHHHHHHHH		36.0325159016
1048PhosphorylationRLSFLEQTEAGLEEG
HHHHHHHHHHHHCCC		20.58-
1099MethylationPLPTMRLRGGQITGG
CCCEEEEECCCCCCC		36.5130987655
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of HMHA1_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of HMHA1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of HMHA1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of HMHA1_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of HMHA1_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"The phagosomal proteome in interferon-gamma-activated macrophages.";
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.;
Immunity 30:143-154(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-23; SER-577; SER-1017;SER-1020 AND SER-1022, AND MASS SPECTROMETRY.
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-23 AND SER-577, AND MASSSPECTROMETRY.
"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1017; SER-1020 ANDSER-1022, AND MASS SPECTROMETRY.

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