RAP2C_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RAP2C_MOUSE
• UniProt AC: Q8BU31
• Protein Name: Ras-related protein Rap-2c
• Gene Name: Rap2c
• Organism: Mus musculus (Mouse).
• Sequence Length: 183
• Subcellular Localization: Cytoplasm. Recycling endosome membrane ; Lipid-anchor ; Cytoplasmic side .
• Protein Description: Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May play a role in SRE-mediated gene transcription..
• Protein Sequence: MREYKVVVLGSGGVGKSALTVQFVTGTFIEKYDPTIEDFYRKEIEVDSSPSVLEILDTAGTEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIVRVKRYEKVPLILVGNKVDLEPEREVMSSEGRALAQEWGCPFMETSAKSKSMVDELFAEIVRQMNYSSLPEKQDQCCTTCVVQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
27	Phosphorylation	TVQFVTGTFIEKYDP EEEEEEECHHHHCCC	16.45	-
31	Ubiquitination	VTGTFIEKYDPTIED EEECHHHHCCCCHHH	50.57	-
48	Phosphorylation	RKEIEVDSSPSVLEI HCCCCCCCCHHHHHH	49.69	20415495
49	Phosphorylation	KEIEVDSSPSVLEIL CCCCCCCCHHHHHHH	19.41	20415495
51	Phosphorylation	IEVDSSPSVLEILDT CCCCCCHHHHHHHHC	41.08	29899451
61	Phosphorylation	EILDTAGTEQFASMR HHHHCCCCHHHHHHH	24.93	20415495
66	Phosphorylation	AGTEQFASMRDLYIK CCCHHHHHHHHEEEE	18.68	19144319
149	Phosphorylation	FMETSAKSKSMVDEL CHHCCCCCHHHHHHH	29.67	22817900
151	Phosphorylation	ETSAKSKSMVDELFA HCCCCCHHHHHHHHH	31.00	22817900
166	Phosphorylation	EIVRQMNYSSLPEKQ HHHHHCCCCCCCHHH	8.36	22817900
167	Phosphorylation	IVRQMNYSSLPEKQD HHHHCCCCCCCHHHC	22.01	-
176	S-palmitoylation	LPEKQDQCCTTCVVQ CCHHHCCCCCEEEEC	2.75	19061864
177	S-palmitoylation	PEKQDQCCTTCVVQ- CHHHCCCCCEEEEC-	2.68	19061864
180	Methylation	QDQCCTTCVVQ---- HCCCCCEEEEC----	1.20	19061864
180	Geranylgeranylation	QDQCCTTCVVQ---- HCCCCCEEEEC----	1.20	19061864
180	Geranylgeranylation	QDQCCTTCVVQ---- HCCCCCEEEEC----	1.20	19061864

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RAP2C_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RAP2C_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RAP2C_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of RAP2C_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"The phagosomal proteome in interferon-gamma-activated macrophages.";
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.;
Immunity 30:143-154(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-66, AND MASSSPECTROMETRY.
PubMed: 19144319