IFIX_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IFIX_MOUSE
• UniProt AC: Q8BV49
• Protein Name: Pyrin and HIN domain-containing protein 1
• Gene Name: Pyhin1
• Organism: Mus musculus (Mouse).
• Sequence Length: 420
• Subcellular Localization: Nucleus.
• Protein Sequence: MVNEYKRIVLLTGLMGINDHDFRMVKSLLSKELKLNRMQDQYDRVKIADLMEDKFPKDAGVDQLIKLYKQIPGLGDIANKLKNEKAKAKRTRTGKRKTAAKRQRQEEPSTSQPMSTTNEDAEPESGRSTPDTQVAQLSLPTASRRNQAIQISPTIASSSGQTSSRSSETLQSIIQSPKTPKRPSSSILDPPVSSGTASSSAQALGVPLATIAKRQRLKNVPKEPSEENGHQQGSKKVMVLKVTEPFSYDVTEEKMFHATVATETEFFRVKVFDIVLKEKFIPNKVLTISNYVGCNGFINIYSASSVSEVNDGEPMNIPLSLRKSANRTPKINYLCSKKRGIFVNGVFTVCKKEEKWNYICYEIGDDTGMMEVEVYGRLTNIACNPGDKLRLICFKLIPDEEKAQLRSTTHSNMQVIKAKN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
27	Phosphorylation	HDFRMVKSLLSKELK HHHHHHHHHHHHHHH	24.11	24719451
109	Phosphorylation	RQRQEEPSTSQPMST HHHHCCCCCCCCCCC	43.93	30635358
110	Phosphorylation	QRQEEPSTSQPMSTT HHHCCCCCCCCCCCC	41.94	30635358
111	Phosphorylation	RQEEPSTSQPMSTTN HHCCCCCCCCCCCCC	36.30	29472430
115	Phosphorylation	PSTSQPMSTTNEDAE CCCCCCCCCCCCCCC	38.47	30635358
116	Phosphorylation	STSQPMSTTNEDAEP CCCCCCCCCCCCCCC	27.65	24704852
117	Phosphorylation	TSQPMSTTNEDAEPE CCCCCCCCCCCCCCC	29.33	27555448
125	Phosphorylation	NEDAEPESGRSTPDT CCCCCCCCCCCCCCC	50.66	24704852
128	Phosphorylation	AEPESGRSTPDTQVA CCCCCCCCCCCCEEE	48.06	24704852
129	Phosphorylation	EPESGRSTPDTQVAQ CCCCCCCCCCCEEEE	24.67	24704852
132	Phosphorylation	SGRSTPDTQVAQLSL CCCCCCCCEEEEEEC	26.58	24704852
138	Phosphorylation	DTQVAQLSLPTASRR CCEEEEEECCCHHCC	21.88	30635358
141	Phosphorylation	VAQLSLPTASRRNQA EEEEECCCHHCCCCC	42.43	30635358
143	Phosphorylation	QLSLPTASRRNQAIQ EEECCCHHCCCCCEE	33.96	30635358
152	Phosphorylation	RNQAIQISPTIASSS CCCCEEECCCCCCCC	10.30	25266776
154	Phosphorylation	QAIQISPTIASSSGQ CCEEECCCCCCCCCC	23.53	25266776
157	Phosphorylation	QISPTIASSSGQTSS EECCCCCCCCCCCCC	22.61	28285833
162	Phosphorylation	IASSSGQTSSRSSET CCCCCCCCCCCCHHH	31.99	24759943
163	Phosphorylation	ASSSGQTSSRSSETL CCCCCCCCCCCHHHH	18.83	28285833
164	Phosphorylation	SSSGQTSSRSSETLQ CCCCCCCCCCHHHHH	39.30	28285833
166	Phosphorylation	SGQTSSRSSETLQSI CCCCCCCCHHHHHHH	34.18	28833060
167	Phosphorylation	GQTSSRSSETLQSII CCCCCCCHHHHHHHH	33.23	28833060
169	Phosphorylation	TSSRSSETLQSIIQS CCCCCHHHHHHHHHC	31.85	28833060
172	Phosphorylation	RSSETLQSIIQSPKT CCHHHHHHHHHCCCC	25.44	23984901
176	Phosphorylation	TLQSIIQSPKTPKRP HHHHHHHCCCCCCCC	20.25	28833060
179	Phosphorylation	SIIQSPKTPKRPSSS HHHHCCCCCCCCCCC	37.11	22942356
184	Phosphorylation	PKTPKRPSSSILDPP CCCCCCCCCCCCCCC	40.53	27600695
185	Phosphorylation	KTPKRPSSSILDPPV CCCCCCCCCCCCCCC	24.87	22802335
186	Phosphorylation	TPKRPSSSILDPPVS CCCCCCCCCCCCCCC	31.35	27600695
225	Phosphorylation	KNVPKEPSEENGHQQ HCCCCCCCCCCCCCC	59.64	28285833
379	Phosphorylation	VEVYGRLTNIACNPG EEEEEEEECCCCCCC	24.18	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IFIX_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IFIX_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IFIX_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of IFIX_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.