PDIA3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PDIA3_MOUSE
• UniProt AC: P27773
• Protein Name: Protein disulfide-isomerase A3
• Gene Name: Pdia3
• Organism: Mus musculus (Mouse).
• Sequence Length: 505
• Subcellular Localization: Endoplasmic reticulum . Endoplasmic reticulum lumen. Melanosome .
• Protein Sequence: MRFSCLALLPGVALLLASARLAAASDVLELTDENFESRVSDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKGIVPLAKVDCTANTNTCNKYGVSGYPTLKIFRDGEEAGAYDGPRTADGIVSHLKKQAGPASVPLRTEEEFKKFISDKDASVVGFFRDLFSDGHSEFLKAASNLRDNYRFAHTNIESLVKEYDDNGEGITIFRPLHLANKFEDKTVAYTEKKMTSGKIKKFIQDSIFGLCPHMTEDNKDLIQGKDLLTAYYDVDYEKNAKGSNYWRNRVMMVAKKFLDAGHKLNFAVASRKTFSHELSDFGLESTTGEVPVVAIRTAKGEKFVMQEEFSRDGKALEQFLQEYFDGNLKRYLKSEPIPESNEGPVKVVVAENFDDIVNEEDKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVIAKMDATANDVPSPYEVKGFPTIYFSPANKKLTPKKYEGGRELNDFISYLQREATNPPIIQEEKPKKKKKAQEDL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
61	Methylation	APWCGHCKRLAPEYE HHCCCHHHHHHHHHH	44.78	-
75	Acetylation	EAAATRLKGIVPLAK HHHHHHHCCCCEEEE	43.21	22826441
82	Succinylation	KGIVPLAKVDCTANT CCCCEEEEEEECCCC	46.41	23806337
82	Acetylation	KGIVPLAKVDCTANT CCCCEEEEEEECCCC	46.41	23806337
85	Glutathionylation	VPLAKVDCTANTNTC CEEEEEEECCCCCCC	4.30	24333276
91	Phosphorylation	DCTANTNTCNKYGVS EECCCCCCCCCCCCC	18.54	-
92	Glutathionylation	CTANTNTCNKYGVSG ECCCCCCCCCCCCCC	4.48	24333276
94	Acetylation	ANTNTCNKYGVSGYP CCCCCCCCCCCCCCC	45.59	22826441
98	Phosphorylation	TCNKYGVSGYPTLKI CCCCCCCCCCCEEEE	28.39	-
104	Acetylation	VSGYPTLKIFRDGEE CCCCCEEEEECCCCC	42.13	22826441
104	Ubiquitination	VSGYPTLKIFRDGEE CCCCCEEEEECCCCC	42.13	22790023
126	Phosphorylation	RTADGIVSHLKKQAG CCCHHHHHHHHHHCC	22.60	-
129	Acetylation	DGIVSHLKKQAGPAS HHHHHHHHHHCCCCC	37.10	22826441
129	Succinylation	DGIVSHLKKQAGPAS HHHHHHHHHHCCCCC	37.10	-
129	Succinylation	DGIVSHLKKQAGPAS HHHHHHHHHHCCCCC	37.10	23806337
136	Phosphorylation	KKQAGPASVPLRTEE HHHCCCCCCCCCCHH	27.66	-
146	Acetylation	LRTEEEFKKFISDKD CCCHHHHHHHCCCCC	50.48	23864654
146	Succinylation	LRTEEEFKKFISDKD CCCHHHHHHHCCCCC	50.48	23954790
147	Acetylation	RTEEEFKKFISDKDA CCHHHHHHHCCCCCC	53.93	22826441
152	Acetylation	FKKFISDKDASVVGF HHHHCCCCCCHHHHH	48.69	23806337
152	Ubiquitination	FKKFISDKDASVVGF HHHHCCCCCCHHHHH	48.69	22790023
173	Ubiquitination	DGHSEFLKAASNLRD CCHHHHHHHHHCCHH	47.42	22790023
173	Acetylation	DGHSEFLKAASNLRD CCHHHHHHHHHCCHH	47.42	23236377
214	Acetylation	RPLHLANKFEDKTVA EEHHHCCCCCCCCEE	44.52	23201123
218	Succinylation	LANKFEDKTVAYTEK HCCCCCCCCEEEECC	37.39	-
218	Succinylation	LANKFEDKTVAYTEK HCCCCCCCCEEEECC	37.39	23806337
218	Acetylation	LANKFEDKTVAYTEK HCCCCCCCCEEEECC	37.39	23806337
225	Acetylation	KTVAYTEKKMTSGKI CCEEEECCCCCCCHH	39.79	23201123
225	Succinylation	KTVAYTEKKMTSGKI CCEEEECCCCCCCHH	39.79	23954790
231	Acetylation	EKKMTSGKIKKFIQD CCCCCCCHHHHHHHH	51.63	23864654
234	Acetylation	MTSGKIKKFIQDSIF CCCCHHHHHHHHHHH	51.69	22826441
244	Glutathionylation	QDSIFGLCPHMTEDN HHHHHCCCCCCCCCC	1.91	24333276
244	S-palmitoylation	QDSIFGLCPHMTEDN HHHHHCCCCCCCCCC	1.91	28526873
244	S-nitrosylation	QDSIFGLCPHMTEDN HHHHHCCCCCCCCCC	1.91	22178444
252	Acetylation	PHMTEDNKDLIQGKD CCCCCCCCHHHCCHH	67.25	23806337
271	Acetylation	YYDVDYEKNAKGSNY EEECCHHHCCCCCCH	56.85	23864654
274	Ubiquitination	VDYEKNAKGSNYWRN CCHHHCCCCCCHHHH	72.73	-
274	Succinylation	VDYEKNAKGSNYWRN CCHHHCCCCCCHHHH	72.73	23954790
289	Acetylation	RVMMVAKKFLDAGHK HHHHHHHHHHHHHHH	41.23	22826441
296	Succinylation	KFLDAGHKLNFAVAS HHHHHHHHHHEEHHC	44.18	23954790
296	Acetylation	KFLDAGHKLNFAVAS HHHHHHHHHHEEHHC	44.18	22826441
303	Phosphorylation	KLNFAVASRKTFSHE HHHEEHHCCCCCCCH	27.93	24899341
305	Ubiquitination	NFAVASRKTFSHELS HEEHHCCCCCCCHHH	51.96	22790023
306	Phosphorylation	FAVASRKTFSHELSD EEHHCCCCCCCHHHH	29.29	22817900
308	Phosphorylation	VASRKTFSHELSDFG HHCCCCCCCHHHHCC	22.68	23984901
312	Phosphorylation	KTFSHELSDFGLEST CCCCCHHHHCCCCCC	28.10	23984901
318	Phosphorylation	LSDFGLESTTGEVPV HHHCCCCCCCCCCCE	35.99	-
319	Phosphorylation	SDFGLESTTGEVPVV HHCCCCCCCCCCCEE	29.46	-
330	Phosphorylation	VPVVAIRTAKGEKFV CCEEEEEECCCCEEE	26.97	-
335	Ubiquitination	IRTAKGEKFVMQEEF EEECCCCEEEEEEEC	52.51	22790023
335	Acetylation	IRTAKGEKFVMQEEF EEECCCCEEEEEEEC	52.51	22826441
362	Ubiquitination	EYFDGNLKRYLKSEP HHHCCCHHHHHHCCC	42.89	-
362	Succinylation	EYFDGNLKRYLKSEP HHHCCCHHHHHHCCC	42.89	23806337
362	Acetylation	EYFDGNLKRYLKSEP HHHCCCHHHHHHCCC	42.89	23806337
366	Acetylation	GNLKRYLKSEPIPES CCHHHHHHCCCCCCC	43.78	22826441
373	Phosphorylation	KSEPIPESNEGPVKV HCCCCCCCCCCCEEE	34.52	27818261
425	Acetylation	ELGEKLSKDPNIVIA HHHHHHCCCCCEEEE	83.84	23201123
425	Ubiquitination	ELGEKLSKDPNIVIA HHHHHHCCCCCEEEE	83.84	22790023
433	Succinylation	DPNIVIAKMDATAND CCCEEEEEEECCCCC	26.62	23954790
437	Phosphorylation	VIAKMDATANDVPSP EEEEEECCCCCCCCC	23.02	30635358
443	Phosphorylation	ATANDVPSPYEVKGF CCCCCCCCCCEECCC	39.71	30635358
460	Acetylation	IYFSPANKKLTPKKY EEECCCCCCCCCCCC	51.79	2388121
460	Ubiquitination	IYFSPANKKLTPKKY EEECCCCCCCCCCCC	51.79	22790023
478	Phosphorylation	RELNDFISYLQREAT HHHHHHHHHHHHHCC	21.56	25338131
494	Acetylation	PPIIQEEKPKKKKKA CCCCCCCCCHHHHHH	62.48	23806337
494	Succinylation	PPIIQEEKPKKKKKA CCCCCCCCCHHHHHH	62.48	23806337
496	Acetylation	IIQEEKPKKKKKAQE CCCCCCCHHHHHHHH	84.22	23864654

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PDIA3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PDIA3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PDIA3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PDIA3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.