COQ3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: COQ3_MOUSE
• UniProt AC: Q8BMS4
• Protein Name: Ubiquinone biosynthesis O-methyltransferase, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03190}
• Gene Name: Coq3 {ECO:0000255|HAMAP-Rule:MF_03190}
• Organism: Mus musculus (Mouse).
• Sequence Length: 370
• Subcellular Localization: Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side .
• Protein Description: O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway..
• Protein Sequence: MWRGGRLGSRGVRLLETLGFGCPSAVAQPPRLTSRSAYSGTQLTRNLQIKPWELGEHGTMCFRSYRMALSCLSRVKTYRTPWKRLYSTSQTTVDSREVKNFQALAHTWWDEYGKFAPLHSMNDLRVPFIRDNLLKTSASHHPGKPLSGMKILDVGCGGGLLTEPLGRLGASVVGIDPVAENIKIAQHHKSFDPVLDKRIQYKVCSLEEAVDESAECFDAVVASEVVEHVSHLEMFIQCCYQVLKPGGSLFITTVNKTQLSYALGIVFAEQIAGIVPKGTHTWEKFVSPEKLESILEPNGLSVETVAGLVYNPFSGYWHWSENTSLNYAAHAVRSRAQEHQEPAESALKGETGALHANTSGSPSVREEQRT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
70	Phosphorylation	RSYRMALSCLSRVKT HHHHHHHHHHHHCCC	11.95	24719451
73	Phosphorylation	RMALSCLSRVKTYRT HHHHHHHHHCCCCCC	39.08	24719451
144	Acetylation	SASHHPGKPLSGMKI CCCCCCCCCCCCCEE	47.43	23576753
150	Acetylation	GKPLSGMKILDVGCG CCCCCCCEEEEECCC	43.58	23576753
156	S-nitrosocysteine	MKILDVGCGGGLLTE CEEEEECCCCCHHCC	4.62	-
156	S-nitrosylation	MKILDVGCGGGLLTE CEEEEECCCCCHHCC	4.62	21278135
156	S-palmitoylation	MKILDVGCGGGLLTE CEEEEECCCCCHHCC	4.62	28526873
197	Acetylation	SFDPVLDKRIQYKVC CCCHHHHHHHHHEEC	47.44	23576753
197	Succinylation	SFDPVLDKRIQYKVC CCCHHHHHHHHHEEC	47.44	23954790
257	Phosphorylation	FITTVNKTQLSYALG EEEEECHHHHHHHHH	29.55	25367039
260	Phosphorylation	TVNKTQLSYALGIVF EECHHHHHHHHHHHH	9.88	25367039
279	Phosphorylation	AGIVPKGTHTWEKFV HCCCCCCCCCCHHCC	23.43	25367039
281	Phosphorylation	IVPKGTHTWEKFVSP CCCCCCCCCHHCCCH	34.85	25367039
284	Acetylation	KGTHTWEKFVSPEKL CCCCCCHHCCCHHHH	42.50	23201123

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of COQ3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of COQ3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of COQ3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of COQ3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.