NLE1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NLE1_MOUSE
• UniProt AC: Q8VEJ4
• Protein Name: Notchless protein homolog 1
• Gene Name: Nle1
• Organism: Mus musculus (Mouse).
• Sequence Length: 485
• Subcellular Localization: Nucleus, nucleolus.
• Protein Description: Plays a role in regulating Notch activity (Probable). Plays a role in regulating the expression of CDKN1A and several members of the Wnt pathway, probably via its effects on Notch activity. Required during embryogenesis for inner mass cell survival..
• Protein Sequence: MAAAVVEEAAAGDVQRLLVQFQDEGGQLLGSPFDVPVDITPDKLQLVCNALLAQEEPLPLAFYVHDAEIVSSLGKTLESQSVETEKIVDIIYQPQAVFRVRAVTRCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGKKLASGCKNGQVLLWDPSTGLQVGRTLTGHSKWITGLSWEPLHMNPECRYVASSSKDGSVRVWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEATVNAQDLQGSLKELKERASSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLARMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLATDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIWRR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAAAVVEEA ------CCCHHHHHH	12.25	-
79	Phosphorylation	SLGKTLESQSVETEK HHCCCHHCCCCCEEE	30.76	-
218	Phosphorylation	HMNPECRYVASSSKD CCCCCCCEEEECCCC	16.42	-
221	Phosphorylation	PECRYVASSSKDGSV CCCCEEEECCCCCCE	25.71	-
222	Phosphorylation	ECRYVASSSKDGSVR CCCEEEECCCCCCEE	31.50	-
223	Phosphorylation	CRYVASSSKDGSVRV CCEEEECCCCCCEEE	32.07	-
323	Ubiquitination	QDLQGSLKELKERAS HHHCHHHHHHHHHHH	63.80	-
409	Phosphorylation	RTGKYLASLRGHVAA CCHHHHHHHHHHHEE	18.92	28059163
460	Phosphorylation	PGHADEVYAVDWSPD CCCCCEEEEEEECCC	10.00	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NLE1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NLE1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NLE1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of NLE1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.