| UniProt ID | HELZ2_MOUSE | |
|---|---|---|
| UniProt AC | E9QAM5 | |
| Protein Name | Helicase with zinc finger domain 2 | |
| Gene Name | Helz2 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 2947 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Helicase that acts as a transcriptional coactivator for a number of nuclear receptors including PPARA, PPARG, THRA, THRB and RXRA.. | |
| Protein Sequence | MASVGCSLRSASTSATNGPSLAGLCAKVDLYLGCSRCTQCLNESTYILREVEHTCPREILLARFKQAAESKIWRKVGRRPSFPTPMRYQVCHYYRPGLGCRRHWNRCTFARSPEEALVWTFELKNNLPRLKLKEAVQGTRAPDRLQTPADTIRAEFGGHFQLLCAICFTCCPPCLCPVDPRGHCPKHQICPTLLIHVIVEGLKRQFVEVRPLPQRRHPLNYCMYVGRGVPCRHGASRCEYAHSAVEMAVWKAEQLDGLQRGDLLTYPLFGENKWKASPNPNPPVTKLYCHACLVTCNSQEAFENHCSSLEHAQMVAFDQAVPWKHRAPPMGLSKFDLCPRPDLCEHGEVCIKAHSKQELQEWVQRAQDMELREQAAWQDGLVPYQARLLAEYQRSSKEVSVMAETIRGVSVTCHPPPVHQAQEKIQHQWVFTIHSEDPLLHVALLNQEPGAAFSLVAPSLPPHQLYAQGKHFCVQSSPAQYKVGVLVQAVAFGSFEQWVVFDFGRRPVLLQKLKLQLGQTHSQGLNGKPAPSHPQELECWHTGNRHVVLEVDWTPEQEALMAKYKLPSLALEFNQIVPDWGPISRSNYRQRMHKFLYEEEAAQQQLVAKLAMKGQVSLKTALETPALGMLFAPPGALYAKVPFHSSLLPDTDQGFLLSRAVSTALVAPVPAPNSTVYQVRLEARASSDHALWLLLPARCCMALGLQAQDSPILEVQFQIDPMTFRFWHQAVDALLEEHLVVPDLPACTLPHPWPTPPSFRGNHKQKLAVGLIAGRRPEGTKHIPPLLIYGPFGTGKTYTLAMAALEVVQQPHTKVLICTHTNSAADIYIREYFHDYVSSGHPEATPLRVMYADRPPRQTDPTTLQYCCLTEDRQAFRPPTGPELVHHRLVVTTTSQARELQVPAGFFSHIFIDEAAQMLECEALIPLSYALSLTRVVLAGDHMQVTPRLFSVPRDKSARHTLLHRLFLYYQQEAHKIAQQSRIIFHENYRSTAAIINFVSHHFYLAKGNPIQASGKVPRHPQHYPLMFCHVAGSPEQDMSMTSWLNSAEVTQVVEKVREIYNTWPHCWGPREQRHICAVSHGAQVSALRQELRRRNLGEVSVGSFEILPGREFRVVVLSSVHNRNSLLSPGAPTSEFFTEPRVLNTVMTRAQSQLVAVGDAVALCSSGACRNLWRSFIRECIEHHSAFPEELSLEQIEQGVAQRQNWASLTLKARGPETEQKSMAQGPQRLIAEGTMVTVKAETRAEAAAKAQTAAVAAEDTASGNSASRDAAAEVSTLEGGMSEEDSESDFWPSDWELNADDAILKELLDESQQVTVTVREDGLLDTVVCSAPQKAREYTNLPSSVLWKFLRSNSKQFRRCSFLQETFERALATPLDDMASSPIQVRGRLNCGMAFTGDEVLVQILGPAGDDRCVPGSLQGRVMGVLKRRRHELAFVCRMDEWDPRIMIPINGSVTKIFVAEMKDPQQVPIHRLIQGQVQRVRHETLKPEDRSTRLFWVRIVLWRERFYYPLGIVLEVLPKAITWEQGLYILDLEHGLKAHTPDPASVSKALQRYRSELNTAAGHREDYRHFLTFTVDPQGACNLDDALSVRDLGPVYEVAVHIADVASLVPKDGALDVEARQQGTVFYAPNREPVLMLPASLCQDALSLLPGQDRLAISLFLTMEKGGGQIKSLRFAPSIIRSDRQLSYEEAEELIKRHPGAGLELPAHLDSVEACVVAACYFSWMLRRQRLSAACYYEPPDEDSVLGFRTAHIMVQEYMIQFNSHVAEFLVSNKHTQTLTPLRWQPTPSRQQLDSVFKKYRGLVPLSLHLCHHSNTDYTPNKQLHLLTSLWKQVQLAAGTQDYSQMVDLIAADDMHPSLAPACLDLRRALGRSVFGRSSQGKQQPAVHHSLQVDWYTWATSPIRRYLDVVLQRLILLALGHRGSTYSNRDIDGLCLDFSRQYASAQSYQRRAYSLHLAIQLKSQPQNKLGFVVDVEMGARCFKVLFPINRETLPDPCPIHYHSLQLAEHPQELVSQTGVRLVWRRRMYSVQASKLPLPLLGTSLDPHTQTVDAALWMKLLMLLKEQRWPEIAALIQEQDKRFHPREKVKIHQSRCGHFVEVVYELGSGDTLQVQLGSSLQRGFLAPTLKLWTVVPGFSLCLEHMERPGDCFSSHVHQALQDQYLQVGEYSGAWGPRCALESLTNAVTENDSIVLHDVHISWDTSQGQLQGTFQLEAAFLQEKCINIHFGCCYLCIRLEGLPLPLDSSLPGPSGLGPFLNIDPNTYTWVAHGLSGDWDHELAGGDWDQENVDDRQEAPKQVYFLIHHMTMEKVPEEVLRPSARFTVEVLSKQLPDLRKEEAVRQLKTASPLVISIALGLPIPEIRWPISGPRRLVSELRWPIPGPRRPVSEPHRPMSGPCGPISEPCRSIPEPCRGNWPRQHSFHKASTSRFLERQNYNIPAGHHKLNQSQDRAVRSALQKQFTVIQGPPGTGKTVVGFHIVYWFHRSNQEQMPTDSSPSGEEQLGGPCVLYCGPSNKSVDVLGGLLLRRKTEMKPLRVYGEQAEATEFPLPGVSNRSLFGKTSQEGRPNQSLRSITLHHRIRQAPNPYAAEIRKFDAQLREGKIFSKEDLRVYRRVLGKARKHELERHSVILCTCSCAASKSLKILNVRQILIDEAGMATEPETLIPLVCFSKTVEKVVLLGDHKQLRPVVKSEQLQSLGMDRSLFERYHRDAIMLDTQYRMHKDICSFPSVEFYGGKLKTWSDLRRLPSILGHTGKPSCSVIFGSVQGHEQKLLVSTEDGNENSRANPEEVTQVVRIIKQLTLDRTVDPKDIAVLTPYNAQAAAISRGLMQRGVTGVTVTSITKSQGSEWRYVIVSTVRTCPRSDVDQRPTKSWLKKFLGFVVDPHQVNVAITRAQEALCIIGDHLLLRCCPLWHRLLDFCEAQHSLVSAEKVRVQRKSALSS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 7 | Phosphorylation | -MASVGCSLRSASTS -CCCCCCCCCCCCCC | 29176673 | ||
| 81 | Phosphorylation | RKVGRRPSFPTPMRY HHHCCCCCCCCCCCE | 24719451 | ||
| 84 | Phosphorylation | GRRPSFPTPMRYQVC CCCCCCCCCCCEEEH | 29472430 | ||
| 93 | Phosphorylation | MRYQVCHYYRPGLGC CCEEEHHHCCCCCCC | 17242355 | ||
| 273 | Ubiquitination | YPLFGENKWKASPNP ECCCCCCCCCCCCCC | 22790023 | ||
| 356 | Ubiquitination | VCIKAHSKQELQEWV EEEHHCCHHHHHHHH | 22790023 | ||
| 594 | Ubiquitination | NYRQRMHKFLYEEEA HHHHHHHHHHCCHHH | 22790023 | ||
| 766 | Ubiquitination | FRGNHKQKLAVGLIA CCCCCCCEEEEEEEC | 22790023 | ||
| 932 | Phosphorylation | IPLSYALSLTRVVLA HHHHHHHHHCEEHHC | 23737553 | ||
| 934 | Phosphorylation | LSYALSLTRVVLAGD HHHHHHHCEEHHCCC | 22324799 | ||
| 1016 | Ubiquitination | NPIQASGKVPRHPQH CCCCCCCCCCCCCCC | 22790023 | ||
| 1222 | Ubiquitination | RGPETEQKSMAQGPQ CCCHHHHHHHHCCCC | 22790023 | ||
| 1336 | Ubiquitination | VVCSAPQKAREYTNL EEECCCHHHHHHCCC | 22790023 | ||
| 1356 | Phosphorylation | WKFLRSNSKQFRRCS HHHHHCCCHHHHHCH | 30635358 | ||
| 1465 | Ubiquitination | KIFVAEMKDPQQVPI EEEEEECCCCCCCCH | 22790023 | ||
| 1543 | Phosphorylation | EHGLKAHTPDPASVS CCCCCCCCCCHHHHH | - | ||
| 1548 | Phosphorylation | AHTPDPASVSKALQR CCCCCHHHHHHHHHH | - | ||
| 1551 | Ubiquitination | PDPASVSKALQRYRS CCHHHHHHHHHHHHH | 22790023 | ||
| 1674 | Ubiquitination | EKGGGQIKSLRFAPS CCCCCCEEEEEECCH | 22790023 | ||
| 1685 | Phosphorylation | FAPSIIRSDRQLSYE ECCHHHHCCCCCCHH | 30635358 | ||
| 1690 | Phosphorylation | IRSDRQLSYEEAEEL HHCCCCCCHHHHHHH | 30635358 | ||
| 1691 | Phosphorylation | RSDRQLSYEEAEELI HCCCCCCHHHHHHHH | 30635358 | ||
| 1801 | Ubiquitination | QQLDSVFKKYRGLVP HHHHHHHHHHCCCHH | 22790023 | ||
| 2067 | Ubiquitination | MKLLMLLKEQRWPEI HHHHHHHHHCCCHHH | 22790023 | ||
| 2333 | Ubiquitination | FTVEVLSKQLPDLRK CHHHHHHHHCCCCCH | 22790023 | ||
| 2378 | Phosphorylation | SGPRRLVSELRWPIP CCCCHHHHEECCCCC | 23140645 | ||
| 2381 | Methylation | RRLVSELRWPIPGPR CHHHHEECCCCCCCC | 24129315 | ||
| 2425 | Phosphorylation | GNWPRQHSFHKASTS CCCCCCCCCCHHHHH | 23140645 | ||
| 2463 | Ubiquitination | AVRSALQKQFTVIQG HHHHHHHHHEEEEEC | 22790023 | ||
| 2564 | Ubiquitination | SNRSLFGKTSQEGRP CCHHHCCCCCCCCCC | 22790023 | ||
| 2609 | Phosphorylation | LREGKIFSKEDLRVY HHCCCCCCHHHHHHH | 24719451 | ||
| 2680 | Ubiquitination | CFSKTVEKVVLLGDH HEECCEEEEEECCCC | 22790023 | ||
| 2688 | Ubiquitination | VVLLGDHKQLRPVVK EEECCCCCCCCCCCC | 22790023 | ||
| 2741 | Ubiquitination | SVEFYGGKLKTWSDL CEEEECCEECCHHHH | 22790023 | ||
| 2803 | Ubiquitination | TQVVRIIKQLTLDRT HHHHHHHHHHHCCCC | 22790023 | ||
| 2822 | Phosphorylation | DIAVLTPYNAQAAAI HCEEECCCHHHHHHH | 17203969 | ||
| 2830 | Phosphorylation | NAQAAAISRGLMQRG HHHHHHHHHHHHHCC | 17203969 | ||
| 2860 | Phosphorylation | EWRYVIVSTVRTCPR EEEEEEEEEEEECCC | 27357545 | ||
| 2861 | Phosphorylation | WRYVIVSTVRTCPRS EEEEEEEEEEECCCC | 27357545 | ||
| 2936 | Ubiquitination | HSLVSAEKVRVQRKS HHHHHHHHHHHHHHH | 22790023 | ||
| 2946 | Phosphorylation | VQRKSALSS------ HHHHHHHCC------ | 24719451 | ||
| 2947 | Phosphorylation | QRKSALSS------- HHHHHHCC------- | 24719451 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of HELZ2_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of HELZ2_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of HELZ2_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of HELZ2_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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