VPS4A_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VPS4A_MOUSE
• UniProt AC: Q8VEJ9
• Protein Name: Vacuolar protein sorting-associated protein 4A
• Gene Name: Vps4a {ECO:0000312|EMBL:AAH18368.1, ECO:0000312|MGI:MGI:1890520}
• Organism: Mus musculus (Mouse).
• Sequence Length: 437
• Subcellular Localization: Prevacuolar compartment membrane ; Peripheral membrane protein . Late endosome membrane; Peripheral membrane protein. Midbody. Membrane-associated in the prevacuolar endosomal compartment. Localizes to the midbody of dividing cells. Localizes to the
• Protein Description: Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. Involved in cytokinesis: retained at the midbody by ZFYVE19/ANCHR and CHMP4C until abscission checkpoint signaling is terminated at late cytokinesis. It is then released following dephosphorylation of CHMP4C, leading to abscission. VPS4A/B are required for the exosomal release of SDCBP, CD63 and syndecan (By similarity)..
• Protein Sequence: MTTSTLQKAIDLVTKATEEDKAKNYEEALRLYQHAVEYFLHAIKYEAHSDKAKESIRAKCMQYLDRAEKLKDYLRNKEKHGKKPVKENQSEGKGSDSDSEGDNPEKKKLQEQLMGAVVMEKPNIRWNDVAGLEGAKEALKEAVILPIKFPHLFTGKRTPWRGILLFGPPGTGKSYLAKAVATEANNSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEVDSLCGSRNENESEAARRIKTEFLVQMQGVGNNNDGTLVLGATNIPWVLDSAIRRRFEKRIYIPLPEEAARAQMFRLHLGSTPHNLTDANIHELARKTEGYSGADISIIVRDSLMQPVRKVQSATHFKKVCGPSRTNPSVMIDDLLTPCSPGDPGAIEMTWMDVPGDKLLEPVVCMSDMLRSLATTRPTVNADDLLKVKKFSEDFGQES

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Acetylation	MTTSTLQKAIDLVTK CCHHHHHHHHHHHHH	50.88	-
51	Acetylation	KYEAHSDKAKESIRA HHHHCCHHHHHHHHH	65.46	23806337
90	Phosphorylation	KPVKENQSEGKGSDS CCCCCCCCCCCCCCC	60.96	21149613
95	Phosphorylation	NQSEGKGSDSDSEGD CCCCCCCCCCCCCCC	37.11	25521595
97	Phosphorylation	SEGKGSDSDSEGDNP CCCCCCCCCCCCCCH	44.74	25521595
99	Phosphorylation	GKGSDSDSEGDNPEK CCCCCCCCCCCCHHH	47.64	25521595
140	Ubiquitination	EGAKEALKEAVILPI HHHHHHHHHCCEEEE	51.15	27667366
156	Ubiquitination	FPHLFTGKRTPWRGI CCCCCCCCCCCCEEE	50.47	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VPS4A_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VPS4A_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VPS4A_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of VPS4A_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.