S27A4_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: S27A4_MOUSE
• UniProt AC: Q91VE0
• Protein Name: Long-chain fatty acid transport protein 4
• Gene Name: Slc27a4
• Organism: Mus musculus (Mouse).
• Sequence Length: 643
• Subcellular Localization: Membrane ; Multi-pass membrane protein . Endoplasmic reticulum membrane.
• Protein Description: Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Appears to be the principal fatty acid transporter in small intestinal enterocytes. Plays a role in the formation of the epidermal barrier. Required for fat absorption in early embryogenesis. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids (VLCFAs). Indirectly inhibits RPE65 via substrate competition and via production of VLCFA derivatives like lignoceroyl-CoA. Prevents light-induced degeneration of rods and cones..
• Protein Sequence: MLLGASLVGALLFSKLVLKLPWTQVGFSLLLLYLGSGGWRFIRVFIKTVRRDIFGGMVLLKVKTKVRRYLQERKTVPLLFASMVQRHPDKTALIFEGTDTHWTFRQLDEYSSSVANFLQARGLASGNVVALFMENRNEFVGLWLGMAKLGVEAALINTNLRRDALRHCLDTSKARALIFGSEMASAICEIHASLEPTLSLFCSGSWEPSTVPVSTEHLDPLLEDAPKHLPSHPDKGFTDKLFYIYTSGTTGLPKAAIVVHSRYYRMASLVYYGFRMRPDDIVYDCLPLYHSAGNIVGIGQCLLHGMTVVIRKKFSASRFWDDCIKYNCTIVQYIGELCRYLLNQPPREAESRHKVRMALGNGLRQSIWTDFSSRFHIPQVAEFYGATECNCSLGNFDSRVGACGFNSRILSFVYPIRLVRVNEDTMELIRGPDGVCIPCQPGQPGQLVGRIIQQDPLRRFDGYLNQGANNKKIANDVFKKGDQAYLTGDVLVMDELGYLYFRDRTGDTFRWKGENVSTTEVEGTLSRLLHMADVAVYGVEVPGTEGRAGMAAVASPISNCDLESFAQTLKKELPLYARPIFLRFLPELHKTGTFKFQKTELRKEGFDPSVVKDPLFYLDARKGCYVALDQEAYTRIQAGEEKL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
98	Phosphorylation	TALIFEGTDTHWTFR EEEEEECCCCCEEHH	30.44	-
100	Phosphorylation	LIFEGTDTHWTFRQL EEEECCCCCEEHHHH	21.10	-
103	Phosphorylation	EGTDTHWTFRQLDEY ECCCCCEEHHHHHHH	11.01	-
125	Phosphorylation	LQARGLASGNVVALF HHHCCCCCCCEEEEE	35.62	-
338	S-palmitoylation	VQYIGELCRYLLNQP HHHHHHHHHHHHCCC	2.03	28680068
411	Phosphorylation	GFNSRILSFVYPIRL CCCHHHHHCCEEEEE	15.42	24719451
414	Phosphorylation	SRILSFVYPIRLVRV HHHHHCCEEEEEEEE	7.31	28285833
595	Acetylation	LHKTGTFKFQKTELR HHHCCCEEEECHHHH	46.88	23806337

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of S27A4_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of S27A4_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of S27A4_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of S27A4_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.