PCID2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PCID2_MOUSE
• UniProt AC: Q8BFV2
• Protein Name: PCI domain-containing protein 2
• Gene Name: Pcid2
• Organism: Mus musculus (Mouse).
• Sequence Length: 399
• Protein Description: Required for B-cell survival through the regulation of the expression of cell-cycle checkpoint MAD2L1 protein during B cell differentiation. [PubMed: 20870947 Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, SEM1, and either centrin CETN2 or CETN3. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and transcription-associated genomic instability. R-loop accumulation does not increase in PCID2-depleted cells.]
• Protein Sequence: MAHITINQYLQQVYEAIDTRDGASCAELVSFKHPHVANPRLQMASPEEKCQQVLEPPYDEMFAAHLRCTYAVGNHDFIEAYKCQTVIVQSFLRAFQAHKEENWALPVMYAVALDLRIFANNADQQLVKKGKSKVGDMLEKAAELLMSCFRVCASDTRAGIEDSKKWGMLFLVNQLFKIYFKINKLHLCKPLIRAIDSSNLKDDYSTAQRITYKYYVGRKAMFDSDFKQAEEYLSFAFEHCHRSSQKNKRMILIYLLPVKMLLGHMPTIELLRKYHLMQFSEVTKAVSEGNLLLLNEALAKHETFFIRCGIFLILEKLKIITYRNLFKKVYLLLKTHQLSLDAFLVALKFMHVEDVDIDEVQCILANLIYMGHIKGYISHQHQKLVVSKQNPFPPLSTVC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAHITINQY ------CCCCCHHHH	11.64	-
14	Phosphorylation	NQYLQQVYEAIDTRD HHHHHHHHHHHHCCC	8.70	29895711
19	Phosphorylation	QVYEAIDTRDGASCA HHHHHHHCCCCCCHH	25.25	29895711
45	Phosphorylation	NPRLQMASPEEKCQQ CCCCCCCCHHHHHHH	27.74	-
69	Phosphorylation	FAAHLRCTYAVGNHD HHHHHHHHEEECCCH	14.21	22871156
70	Phosphorylation	AAHLRCTYAVGNHDF HHHHHHHEEECCCHH	11.69	22871156
81	Phosphorylation	NHDFIEAYKCQTVIV CCHHHHHHCCCHHHH	10.25	22871156
133	Acetylation	LVKKGKSKVGDMLEK HHHCCCCHHHHHHHH	54.44	23806337
147	Phosphorylation	KAAELLMSCFRVCAS HHHHHHHHHHHHHHC	15.29	28285833
204	Phosphorylation	SSNLKDDYSTAQRIT CCCCCCCCCCCHHHH	20.32	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PCID2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PCID2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PCID2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PCID2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.