TBA8_MOUSE - dbPTM
TBA8_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TBA8_MOUSE
UniProt AC Q9JJZ2
Protein Name Tubulin alpha-8 chain
Gene Name Tuba8
Organism Mus musculus (Mouse).
Sequence Length 449
Subcellular Localization Cytoplasm, cytoskeleton.
Protein Description Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain..
Protein Sequence MRECISVHVGQAGVQIGNACWELFCLEHGIQADGTFGTQASKINDDDSFTTFFSETGNGKHVPRAVMVDLEPTVVDEVRAGTYRQLFHPEQLITGKEDAANNYARGHYTVGKESIDLVLDRIRKLTDACSGLQGFLIFHSFGGGTGSGFTSLLMERLSLDYGKKSKLEFAIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLVTYAPIISAEKAYHEQLSVAEITSSCFEPNSQMVKCDPRHGKYMACCMLYRGDVVPKDVNVAIAAIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGTDSFEEENEGEEF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
48PhosphorylationSKINDDDSFTTFFSE
CCCCCCCCCEECEEE		31.3322817900
94PhosphorylationFHPEQLITGKEDAAN
CCHHHHCCCCHHHHH		51.2827600695
96UbiquitinationPEQLITGKEDAANNY
HHHHCCCCHHHHHHC		43.7127667366
103PhosphorylationKEDAANNYARGHYTV
CHHHHHHCCCCCCCC		9.4825367039
163UbiquitinationRLSLDYGKKSKLEFA
HHCCCCCCCCCCEEE		47.8722790023
210PhosphorylationMVDNEAIYDICRRNL
EECHHHHHHHHHCCC		13.3022817900
223PhosphorylationNLDIERPTYTNLNRL
CCCCCCCCHHCHHHH		49.5522817900
224PhosphorylationLDIERPTYTNLNRLI
CCCCCCCHHCHHHHH		9.0522817900
225PhosphorylationDIERPTYTNLNRLIS
CCCCCCHHCHHHHHH		35.3922817900
232PhosphorylationTNLNRLISQIVSSIT
HCHHHHHHHHHHHHH		20.6026824392
236PhosphorylationRLISQIVSSITASLR
HHHHHHHHHHHHHCC		20.0423984901
237PhosphorylationLISQIVSSITASLRF
HHHHHHHHHHHHCCC		17.0523984901
337PhosphorylationVAIAAIKTKRTIQFV
HHHHHCCCCCEEEEE		21.4629899451
340PhosphorylationAAIKTKRTIQFVDWC
HHCCCCCEEEEEEEC		22.2321183079
347S-palmitoylationTIQFVDWCPTGFKVG
EEEEEEECCCCEEEE		1.5528526873
352UbiquitinationDWCPTGFKVGINYQP
EECCCCEEEEEECCC		40.68-
352AcetylationDWCPTGFKVGINYQP
EECCCCEEEEEECCC		40.687212419
357PhosphorylationGFKVGINYQPPTVVP
CEEEEEECCCCEECC		22.0725521595
361PhosphorylationGINYQPPTVVPGGDL
EEECCCCEECCCCCH		40.6025159016
370UbiquitinationVPGGDLAKVQRAVCM
CCCCCHHHHHHHHHH		46.3127667366
379PhosphorylationQRAVCMLSNTTAIAE
HHHHHHHCCHHHHHH		12.7822817900
381PhosphorylationAVCMLSNTTAIAEAW
HHHHHCCHHHHHHHH		17.7723984901
382PhosphorylationVCMLSNTTAIAEAWA
HHHHCCHHHHHHHHH		21.9523984901
394UbiquitinationAWARLDHKFDLMYAK
HHHHCCCCCCHHHEE		39.9927667366
399PhosphorylationDHKFDLMYAKRAFVH
CCCCCHHHEEEHHHH		19.1026745281
401UbiquitinationKFDLMYAKRAFVHWY
CCCHHHEEEHHHHHH		27.1127667366
401AcetylationKFDLMYAKRAFVHWY
CCCHHHEEEHHHHHH		27.117675709
408PhosphorylationKRAFVHWYVGEGMEE
EEHHHHHHCCCCCCC		5.4525777480
437PhosphorylationKDYEEVGTDSFEEEN
HHHHHHCCCCCCCCC		33.3826745281
439PhosphorylationYEEVGTDSFEEENEG
HHHHCCCCCCCCCCC		34.1026745281
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TBA8_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TBA8_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TBA8_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of TBA8_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TBA8_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale identification and evolution indexing of tyrosinephosphorylation sites from murine brain.";
Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.;
J. Proteome Res. 7:311-318(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-103 AND TYR-357, ANDMASS SPECTROMETRY.

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