VTA1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VTA1_MOUSE
• UniProt AC: Q9CR26
• Protein Name: Vacuolar protein sorting-associated protein VTA1 homolog
• Gene Name: Vta1
• Organism: Mus musculus (Mouse).
• Sequence Length: 309
• Subcellular Localization: Cytoplasm . Endosome membrane ; Peripheral membrane protein .
• Protein Description: Involved in the endosomal multivesicular bodies (MVB) pathway. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Thought to be a cofactor of VPS4A/B, which catalyzes disassembles membrane-associated ESCRT-III assemblies (By similarity). Involved in the sorting and down-regulation of EGFR..
• Protein Sequence: MAALAPLPPLPAQFKSIQHHLRTAQEHDKRDPVVAYYCRLYAMQTGMKIDSKTPECRKFLSKLMDQLEALKKQLGDNEAVTQEIVGCAHLENYALKMFLYADNEDRAGRFHKNMIKSFYTASLLIDVITVFGELTDENVKHRKYARWKATYIHNCLKNGETPQAGPVGIEEENDVEENEDVGATSLPTQPPQPSSSSAYDPSNLAPGSYSGIQIPPGAHAPANTPAEVPHSTGVTSNAVQPSPQTVPAAPAVDPDLYTASQGDIRLTPEDFARAQKYCKYAGSALQYEDVGTAVQNLQKALRLLTTGRE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAALAPLPP ------CCCCCCCCC	15.93	-
15	Acetylation	PPLPAQFKSIQHHLR CCCCHHHHHHHHHHH	34.27	22902405
52	Malonylation	TGMKIDSKTPECRKF HCCCCCCCCHHHHHH	65.44	32601280
62	Acetylation	ECRKFLSKLMDQLEA HHHHHHHHHHHHHHH	50.40	22902405
116	Acetylation	RFHKNMIKSFYTASL HHCHHHHHHHHHHHH	24.60	19845091
140	Acetylation	ELTDENVKHRKYARW HCCCCCHHCHHHHHH	49.64	19845099
155	Glutathionylation	KATYIHNCLKNGETP HHHHHHHHHHCCCCC	3.37	24333276
277	Phosphorylation	DFARAQKYCKYAGSA HHHHHHHHHHHCCCC	5.10	20139300
280	Phosphorylation	RAQKYCKYAGSALQY HHHHHHHHCCCCCCC	16.78	25619855
283	Phosphorylation	KYCKYAGSALQYEDV HHHHHCCCCCCCCCH	20.03	25619855
287	Phosphorylation	YAGSALQYEDVGTAV HCCCCCCCCCHHHHH	18.23	25619855

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VTA1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VTA1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VTA1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of VTA1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.