dbPTM

TAB1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TAB1_MOUSE
UniProt AC	Q8CF89
Protein Name	TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
Gene Name	Tab1
Organism	Mus musculus (Mouse).
Sequence Length	502
Subcellular Localization
Protein Description	May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis..
Protein Sequence	MAAQRRSLLQSEQQPSWTDDLPLCHLSGVGSASNRSYSADGKGTESHPPEDNWLKFRSENNCFLYGVFNGYDGNRVTNFVAQRLSAELLLGQLNTEHTEADVRRVLLQAFDVVERSFLESIDDALAEKASLQSQLPEGVPQHQLPPQYQKILERLKALEREISGGAMAVVAVLLNSKLYVANVGTNRALLCKSTVDGLQVTQLNMDHTTENEDELFRLSQLGLDAGKIKQMGVICGQESTRRIGDYKVKYGYTDIDLLSAAKSKPIIAEPEIHGAQPLDGVTGFLVLMSEGLYKALEAAHGPGQANQEIAAMIDTEFAKQTSLDAVAQAVVDRVKRIHSDTFASGGERAKFCPRHEDMTLLVRNFGYPLGEMSQPTPTPAPGGRVYPVSVPYSSAQSTSKTSVTLSLVMPSQGQMVNGSHSASTLDEATPTLTNQSPTLTLQSTNTHTQSSSSSSDGGLFRSRPAHSLPPGEDGRVEPYVDFAEFYRLWSVDHGEQSVMTAP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MAAQRRSLLQSEQQ -CHHHHHHHHHCCCC	35.30	26824392
11	Phosphorylation	QRRSLLQSEQQPSWT HHHHHHHCCCCCCCC	37.02	25619855
16	Phosphorylation	LQSEQQPSWTDDLPL HHCCCCCCCCCCCCC	37.97	25619855
18	Phosphorylation	SEQQPSWTDDLPLCH CCCCCCCCCCCCCEE	24.79	25619855
27	Phosphorylation	DLPLCHLSGVGSASN CCCCEECCCCCCCCC	14.04	25619855
393	O-linked_Glycosylation	YPVSVPYSSAQSTSK EEEECCCCCCCCCCC	17.09	30059200
394	O-linked_Glycosylation	PVSVPYSSAQSTSKT EEECCCCCCCCCCCC	25.20	30059200
436	Phosphorylation	TPTLTNQSPTLTLQS CCCCCCCCCEEEEEE	23.17	-
440	Phosphorylation	TNQSPTLTLQSTNTH CCCCCEEEEEECCCC	25.81	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TAB1_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TAB1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TAB1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
ITCH_MOUSE	Itch	physical	25714464

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TAB1_MOUSE

Related Literatures of Post-Translational Modification