KLH41_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KLH41_MOUSE
• UniProt AC: A2AUC9
• Protein Name: Kelch-like protein 41
• Gene Name: Klhl41
• Organism: Mus musculus (Mouse).
• Sequence Length: 606
• Subcellular Localization: Cytoplasm . Cytoplasm, cytoskeleton . Cell projection, pseudopodium . Cell projection, ruffle . Cytoplasm, myofibril, sarcomere, M line . Sarcoplasmic reticulum membrane . Endoplasmic reticulum membrane . Predominantly cytoplasmic but can colocalize
• Protein Description: Involved in skeletal muscle development and differentiation. Regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. Required for pseudopod elongation in transformed cells..
• Protein Sequence: MDSQRELAEELRLYQSTLLQDGLKDLLEEKKFIDCTLKAGDKSFPCHRLILSACSPYFREYFLSEIEEEKKKEVALDNVDPAILDLIIKYLYSASIDLNDGNVQDIFALSSRFQIPSVFTVCVSYLQKRLAPGNCLAILRLGLLLDCPRLAISAREFVSDRFVQICKEEDFMQLSPQELISVISNDSLNVEKEEVVFEAVMKWVRTDKENRAKNLSEVFDCIRFRLMAEKYFKDHVEKDDIIKSNPEVQKKIKVLKDAFAGKLPEPSKNAEKAGAGEVNGDVGDEDLLPGYLNDIPRHGMFVKDLILLVNDTAAVAYDPMENECYLTALAEQIPRNHSSLVTQQNQVYVVGGLYVDEENKDQPLQSYFFQLDNVTSEWVGLPPLPSARCLFGLGEVDDKIYVVAGKDLQTEASLDSVLCYDPVAAKWSEVKNLPIKVYGHNVISHNGMIYCLGGKTDDKKCTNRVFIYNPKKGDWKDLAPMKTPRSMFGVAIHKGKIVIAGGVTEDGLSASVEAFDLKTNKWEVMTEFPQERSSISLVSLAGALYAIGGFAMIQLESKEFAPTEVNDIWKYEDDKKEWAGMLKEIRYASGASCLATRLNLFKLSKL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MDSQRELAEE -----CHHHHHHHHH		22210690
57	Phosphorylation	ILSACSPYFREYFLS HHHHCCHHHHHHHHH		28464351
153	Phosphorylation	DCPRLAISAREFVSD CCCHHHHHHHHHHHH		23737553
244	Phosphorylation	EKDDIIKSNPEVQKK CHHHHHHCCHHHHHH		28464351
471	Ubiquitination	RVFIYNPKKGDWKDL CEEEECCCCCCHHHC		22790023
476	Acetylation	NPKKGDWKDLAPMKT CCCCCCHHHCCCCCC		23864654
482	Acetylation	WKDLAPMKTPRSMFG HHHCCCCCCCHHHCE		23864654
583	Ubiquitination	KEWAGMLKEIRYASG HHHHHHHHHHHHHHH		22790023

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KLH41_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KLH41_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KLH41_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of KLH41_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.