BLMH_MOUSE - dbPTM
BLMH_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID BLMH_MOUSE
UniProt AC Q8R016
Protein Name Bleomycin hydrolase
Gene Name Blmh
Organism Mus musculus (Mouse).
Sequence Length 455
Subcellular Localization Cytoplasm.
Protein Description The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B-aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity..
Protein Sequence MNNAGLNSEKVSALIQKLNSDPQFVLAQNVGTTHDLLDICLRRATVQGAQHVFQHVVPQEGKPVTNQKSSGRCWIFSCLNVMRLPFMKKFNIEEFEFSQSYLFFWDKVERCYFFLNAFVDTAQKKEPEDGRLVQYLLMNPTNDGGQWDMLVNIVEKYGVVPKKCFPESHTTEATRRMNDILNHKMREFCIRLRNLVHSGATKGEISSTQDAMMEEIFRVVCICLGNPPETFTWEYRDKDKNYHKIGPITPLQFYKEHVKPLFNMEDKICFVNDPRPQHKYNKLYTVDYLSNMVGGRKTLYNNQPIDFLKKMVAASIKDGEAVWFGCDVGKHFNGKLGLSDMNVYDHELVFGVSLKNMNKAERLAFGESLMTHAMTFTAVSEKDNQEGTFVKWRVENSWGEDHGHKGYLCMTDEWFSEYVYEVVVDKKHVPEEVLAVLEQEPIVLPAWDPMGALAE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MNNAGLNS
-------CCCCCCCH		8.66-
162UbiquitinationEKYGVVPKKCFPESH
HHHCCCCCCCCCCCC		51.0327667366
163MalonylationKYGVVPKKCFPESHT
HHCCCCCCCCCCCCH		34.7326320211
164S-nitrosylationYGVVPKKCFPESHTT
HCCCCCCCCCCCCHH		9.5621278135
164S-nitrosocysteineYGVVPKKCFPESHTT
HCCCCCCCCCCCCHH		9.56-
164GlutathionylationYGVVPKKCFPESHTT
HCCCCCCCCCCCCHH		9.5624333276
198PhosphorylationRLRNLVHSGATKGEI
HHHHHHHCCCCCCCC		23.7325777480
201PhosphorylationNLVHSGATKGEISST
HHHHCCCCCCCCCHH		43.0125777480
206PhosphorylationGATKGEISSTQDAMM
CCCCCCCCHHHHHHH		24.0325777480
207PhosphorylationATKGEISSTQDAMME
CCCCCCCHHHHHHHH		35.4325777480
208PhosphorylationTKGEISSTQDAMMEE
CCCCCCHHHHHHHHH		24.5525777480
242PhosphorylationYRDKDKNYHKIGPIT
EECCCCCCCCCCCCC		15.3826060331
249PhosphorylationYHKIGPITPLQFYKE
CCCCCCCCCHHHHHH		22.5326060331
254PhosphorylationPITPLQFYKEHVKPL
CCCCHHHHHHHCCCC		11.5126060331
259AcetylationQFYKEHVKPLFNMED
HHHHHHCCCCCCCCC		37.6022826441
284PhosphorylationQHKYNKLYTVDYLSN
CCCCCCCHHHHHHHC		13.3124759943
285PhosphorylationHKYNKLYTVDYLSNM
CCCCCCHHHHHHHCC		19.8224759943
288PhosphorylationNKLYTVDYLSNMVGG
CCCHHHHHHHCCCCC		14.0124759943
297UbiquitinationSNMVGGRKTLYNNQP
HCCCCCCCCCCCCCC		46.2722790023
309AcetylationNQPIDFLKKMVAASI
CCCHHHHHHHHHHHC		38.5222826441
391MalonylationNQEGTFVKWRVENSW
CCCCEEEEEEEECCC		25.7026320211
391AcetylationNQEGTFVKWRVENSW
CCCCEEEEEEEECCC		25.7023806337
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of BLMH_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of BLMH_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of BLMH_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of BLMH_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of BLMH_MOUSE

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Related Literatures of Post-Translational Modification

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