| UniProt ID | PERE_MOUSE | |
|---|---|---|
| UniProt AC | P49290 | |
| Protein Name | Eosinophil peroxidase | |
| Gene Name | Epx | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 716 | |
| Subcellular Localization | Cytoplasmic granule. Cytoplasmic granules of eosinophils. | |
| Protein Description | Mediates tyrosine nitration of secondary granule proteins in mature resting eosinophils.. | |
| Protein Sequence | MMQQLLALVGALATLILTQHAEGTAPASPSPVEISVLRDCIAEAKLLVDTAYNHTQKSIMQRLRSGSASPMDLLAYFKQPVAATRRVVQAADYMHVALGLLEERLQPRGSRPFNATDVLTEPQLRLLSQASGCALQDQAERCSNKYRTITGRCNNKKHPWLGASNQALARWLPAEYEDHRSLPFGWTPGKRRNGFLLPLVRDVSNQIVRFPSKKLTSDRGRALMFMQWGQFIDHDLDFSPESPARVAFSMGVDCEKTCAQLPPCFPIKIPRNDPRIKNQRDCIPFFRSAPACPQNRNKVRNQINALTSFVDASMVYGSEVTLALRLRNRTNFLGLLATNQRFQDNGRALLPFDNLHEDPCLLTNRSARIPCFLAGDTRSSETPKLTALHTLFVREHNRLAAELRRLNPHWSGDKLYNEARKIVGAMVQIITYRDFLPLVLGRARIRRTLGPYRGYCSNVDPRVANVFTLAFRFGHTMLQPFMFRLDSQYRASAPNSHVPLSSVFFASWRIIHEGGIDPILRGLMATPAKLNRQDSMLVDELRDKLFQQVRRIGLDLAALNMQRSRDHGLPGYNAWRRFCGLSQPRNLAQLSRVLKNQDLARKFLRLYKTPDNIDIWVGAIAEPLLPGARVGPLLACLFENQFRRARDGDRFWWQKWGVFTKRQRKALRRISLSRIVCDNTGITTVSRDIFRANIYPQGFVSCSRIPKLNLSAWRGK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 14 | Phosphorylation | ALVGALATLILTQHA HHHHHHHHHHHHHHC | 18.38 | 29109428 | |
| 30 | Phosphorylation | GTAPASPSPVEISVL CCCCCCCCCCEEHHH | 38.80 | 29109428 | |
| 35 | Phosphorylation | SPSPVEISVLRDCIA CCCCCEEHHHHHHHH | 11.12 | 29109428 | |
| 53 | N-linked_Glycosylation | LLVDTAYNHTQKSIM HHHHHHCHHHHHHHH | 29.30 | - | |
| 114 | N-linked_Glycosylation | PRGSRPFNATDVLTE CCCCCCCCCCCCCCH | 44.61 | - | |
| 328 | N-linked_Glycosylation | TLALRLRNRTNFLGL HHHHHHHCCCCHHHH | 60.77 | - | |
| 364 | N-linked_Glycosylation | EDPCLLTNRSARIPC CCCCCCCCCCCCCCE | 35.56 | - | |
| 489 | Nitrated tyrosine | MFRLDSQYRASAPNS HHHHCHHHCCCCCCC | 16.46 | - | |
| 489 | Nitration | MFRLDSQYRASAPNS HHHHCHHHCCCCCCC | 16.46 | - | |
| 671 | Phosphorylation | RKALRRISLSRIVCD HHHHHHHCCHHHCCC | 20.62 | 19854140 | |
| 673 | Phosphorylation | ALRRISLSRIVCDNT HHHHHCCHHHCCCCC | 17.11 | 22982522 | |
| 709 | N-linked_Glycosylation | CSRIPKLNLSAWRGK CCCCCCCCCCCCCCC | 37.77 | - | |
| 711 | Phosphorylation | RIPKLNLSAWRGK-- CCCCCCCCCCCCC-- | 25.39 | 22942356 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PERE_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PERE_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PERE_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of PERE_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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