dbPTM

ZC3HA_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ZC3HA_MOUSE
UniProt AC	Q8R205
Protein Name	Zinc finger CCCH domain-containing protein 10
Gene Name	Zc3h10
Organism	Mus musculus (Mouse).
Sequence Length	435
Subcellular Localization	Nucleus .
Protein Description	Specific regulator of miRNA biogenesis. Binds, via the C3H1-type zinc finger domains, to the binding motif 5'-GCAGCGC-3' on microRNA pri-MIR143 and negatively regulates the processing to mature microRNA..
Protein Sequence	MPDRDSYANGTGSSGGGPGGGGSEEASGAGTGSGGATSDAICRDFLRNVCKRGKRCRYRHPDMSEVSNLGVSKNEFIFCHDFQNKECSRPNCRFIHGSKEDEDGYKKTGELPPRLRQKVAAGLGLSPADLPNGKEEVPICRDFLKGDCQRGAKCKFRHLQRDFEFDARGGGGTGGGGSTGSAPPGRRHDLYDIYDLPERGFEDHEPGPKRRRGGCCPPDGPHFESYECNLAPLRGVECRLLEEENALLRKRVEELKKQVSNLLATNEVLLEQNAQFRNQAKVMTLSSTAPATEQTLAPTVGTVATFNHGIAQTHTTLSSQALQPRPVSQQELVAPTGAPAAPPTNAAPPAAPPPPPPHLNPEITPLSAALAQTIAQGMAPPPVSMAPVAVSVAPVAPVAVSMAQPLAGITMSHTTTPMVTYPIASQSMRITAMPH

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
108	Phosphorylation	DEDGYKKTGELPPRL CCCCCCCCCCCCHHH	31.56	25619855
186	Methylation	TGSAPPGRRHDLYDI CCCCCCCCCCCCCCH	38.24	24129315
187	Methylation	GSAPPGRRHDLYDIY CCCCCCCCCCCCCHH	33.32	24129315
373	Phosphorylation	LSAALAQTIAQGMAP HHHHHHHHHHCCCCC	16.81	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
126	S	Phosphorylation	Kinase	P38A	P47811	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ZC3HA_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ZC3HA_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of ZC3HA_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ZC3HA_MOUSE

Related Literatures of Post-Translational Modification