| UniProt ID | ICE1_MOUSE | |
|---|---|---|
| UniProt AC | E9Q286 | |
| Protein Name | Little elongation complex subunit 1 | |
| Gene Name | Ice1 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 2241 | |
| Subcellular Localization | Nucleus . Nucleus, Cajal body . Colocalizes with COIL in subnuclear Cajal and histone locus bodies. Associates to transcriptionally active chromatin at snRNA genes. | |
| Protein Description | Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies (By similarity).. | |
| Protein Sequence | MMPGETHPAAPGPADLARCQGCASLQQNLNEYVEALIALKQKIINTDNLLTEYQKKCDELQFARRENSTLHHQVEQMLQKISPLQKCQEELGSLKAELEEKKSSLKLYQDTHQEYARVKEECLRTDAQKKKLEAKVKKLEEAAVKQTQDFKQLRNEKKILEKEFKKTQERLDEFSKQKNEKELRHIGTQISSDSHGSIDKRKVKVLLKELWLCVNTAHRLSGEGGRRIPEKPAKGSSAARASEQDELLPVQGGPARAADMRSFFSKLSMEMEGDFSSSESAEEELPSGASPSTEHAFCEERHSEVSGQRPDDGNRTNVYDHEHFFDDDLQAAIDFFKLPPPLLSPVPSPPPMASGSLPSSLAPESFFGEFTDSSDSDSVPPRDSMESALEDYTAESRAYFDLLEKIKRSDQYVKKPGSLEATQAVNSLTPLGFVTGRTALGEPSAAASLAQGRHWTESSEFVRDRGDSVEEAERMVEAREVDKSVQVGKGLLKHNRKLWLEMASRGPARKKEAGAGESEICFSSLGKRTFSELIESEGKTLSSKALCPSQSEFSKRTLTDGSASKSPCVTGSGRFQRRERDVRESTPQSGICAAAAGRGHSARLPSSSSATSVPVSVCSNHQTPWPGCVSVGTPAEGTCTEQKSPTRTLNTFLLRSEPTACFPKENDPENSLSTLSPKSKLGTSTFSDWKSRGLESFSTLKSTAKGHSLPQSVFPKPTGGGQCKGRGPGATLILPKSDWTSLARSQAGFTRRSSGSADSTSWHRSDVLRRGSGGSPRASSEYQQRTRLQLEKATPASQNSSLTAMHGPSGESTIPPESNAAAALLPNQVSVITKQARPRRVLGSSLEPWQPHGNTLSPAVNGGKETGLMPSVSACVGDGDPIAQVPEQIADKETPSPEVSVSWRNPICDSPSDSLLAENFSCSTDRKLPFSSEDNIFQCAMNEHLQQKPTKSPQTTQSGASRLEAGELLPSGVTSGVFPAEQVPHGPHHQADTEAPVVARESHSAPQNASAPPVVPSRGPLRARVPTVPVCPSSLSRAEEETQGTSQSSLPGASYCYTGIRERGEEDTEVEDEAVSCSEGEHEAEAVMGRRQQEQAEDSHRPLGDPEAGVGEAGHPSDVGDLTSALEECNLSTLLYIDKLSTSEVVMVLESCQLGDYSSRVSASECASKGSLSEEMNTELRQSEISRKKCGKRLWEEKLLRASEEWAESEGDDSCGRTSCQHAQCPLEVPSDVLTKTGEELDTNPVDCGGTDTEHALLESTHHSQAAEDLTEDALPEETSSPMPHTAELPDPSAVDGGGSSPLSSRSDPEHIQSSYEDEPNSGECLSIGEEGLAEPGELLTLSSDSSTPPRLEQSSDCVAETAFRYQISAVTSEVISVLINKDQDLVIEKGDNWTIISGVAISPGMEQVVLCDTLGDAASSQDQGGLDDGSMEKSPEASPSGPLPQEPPCGGDLSGAQEDISSNGQSANFDKSRLRNRPVKPSIWIRSQIYDQTLETEKVASDHTYYNWKLEPLGKNKPRSKISNKDQASKLAKTLVLNRGEVHLNEVPQPASGEGTNIKLPRSQAQPIMAGTDRSTPTNCSPDTLSKIRQEVGPPLPPLLPPLIATPPRSSQTLSPLVPNSGPSSRSSPAGHVSPLCEVPGPPVLSPWPEELQQASPLDPSPSPSTAAASGRIVSSPLQFCAATPKHALPVPGRLPSCAPGHAAVSGPQQENSVKILDTMYPELSARARTLSLLKGNMQLSRGSTVDGKVLPGRVSALLGLKAITSTSTAFVLTGGSSGADGSQGKSQDSGVQQDAGGKRTLAVSMLRSAKRLRLDNKSPEPDTREVTGEGVPEDPQGGSPLAEVVPAEEEQADVPVCSAASLLRVNPREMAESYNIAITRALRKIAESSFDLLPVIRSHVYVGNISKKPVMRDQEKEVVYEFSTTNKHLGEYLLRSILSELKIQKTSLDHSYIHALCRVYVGICRQLGDLERARLFCYSLLKEDFPESEKLTLFIANMWREVFLSQSAISEAMQLVARQRARGEVLNCLRAFLSWEKNAPIDVGIVVSKLLLTIQLCPKTEFQSSEEFGEDLSANIWEYIFAIDLLCCHQRWIWTHDNIISKELWPVMDKWIKYRKGHSNIAYTPDVIVASVLRLIGRLGQLGLKEGFPTAVKNISSVIGMFIQHAQDEDIPWGVQLAAVYALCDLSPSNPAEISKILEAWRTQTSNAIPSAIVHCLEEVGSLSADGSAGCTSKGDSAP | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 40 | Ubiquitination | VEALIALKQKIINTD HHHHHHHHHHHHCCC | - | ||
| 82 | Phosphorylation | EQMLQKISPLQKCQE HHHHHHHCHHHHHHH | 24719451 | ||
| 181 | Acetylation | FSKQKNEKELRHIGT HHHHHCHHHHHHHCH | 7718783 | ||
| 303 | Phosphorylation | AFCEERHSEVSGQRP CCHHHHCCCCCCCCC | - | ||
| 399 | Phosphorylation | YTAESRAYFDLLEKI HHHHHHHHHHHHHHH | - | ||
| 468 | Phosphorylation | FVRDRGDSVEEAERM HHHHCCCCHHHHHHH | 29899451 | ||
| 518 | Phosphorylation | KEAGAGESEICFSSL CCCCCCCCCCCCHHC | 23140645 | ||
| 523 | Phosphorylation | GESEICFSSLGKRTF CCCCCCCHHCCCCHH | 23140645 | ||
| 524 | Phosphorylation | ESEICFSSLGKRTFS CCCCCCHHCCCCHHH | 23140645 | ||
| 531 | Phosphorylation | SLGKRTFSELIESEG HCCCCHHHHHHHCCC | 29899451 | ||
| 566 | Phosphorylation | TDGSASKSPCVTGSG CCCCCCCCCCCCCCC | 29514104 | ||
| 585 | Phosphorylation | RERDVRESTPQSGIC CCCCHHHCCCCCCCC | 28066266 | ||
| 586 | Phosphorylation | ERDVRESTPQSGICA CCCHHHCCCCCCCCH | 28066266 | ||
| 589 | Phosphorylation | VRESTPQSGICAAAA HHHCCCCCCCCHHHC | 28066266 | ||
| 616 | Phosphorylation | SATSVPVSVCSNHQT CCCCCCEEHHCCCCC | 25293948 | ||
| 619 | Phosphorylation | SVPVSVCSNHQTPWP CCCEEHHCCCCCCCC | 25293948 | ||
| 623 | Phosphorylation | SVCSNHQTPWPGCVS EHHCCCCCCCCCEEE | 25293948 | ||
| 630 | Phosphorylation | TPWPGCVSVGTPAEG CCCCCEEEECCCCCC | 25293948 | ||
| 633 | Phosphorylation | PGCVSVGTPAEGTCT CCEEEECCCCCCCCC | 25293948 | ||
| 638 | Phosphorylation | VGTPAEGTCTEQKSP ECCCCCCCCCCCCCC | 25293948 | ||
| 640 | Phosphorylation | TPAEGTCTEQKSPTR CCCCCCCCCCCCCCC | 25293948 | ||
| 644 | Phosphorylation | GTCTEQKSPTRTLNT CCCCCCCCCCCEECE | 25293948 | ||
| 646 | Phosphorylation | CTEQKSPTRTLNTFL CCCCCCCCCEECEEH | 25293948 | ||
| 648 | Phosphorylation | EQKSPTRTLNTFLLR CCCCCCCEECEEHHC | 26643407 | ||
| 651 | Phosphorylation | SPTRTLNTFLLRSEP CCCCEECEEHHCCCC | 28285833 | ||
| 671 | Phosphorylation | KENDPENSLSTLSPK CCCCCCCCCCCCCCC | 25293948 | ||
| 673 | Phosphorylation | NDPENSLSTLSPKSK CCCCCCCCCCCCCCC | 25293948 | ||
| 674 | Phosphorylation | DPENSLSTLSPKSKL CCCCCCCCCCCCCCC | 26643407 | ||
| 676 | Phosphorylation | ENSLSTLSPKSKLGT CCCCCCCCCCCCCCC | 25521595 | ||
| 737 | Phosphorylation | ATLILPKSDWTSLAR CEEEEEHHHHHHHHH | 24719451 | ||
| 740 | Phosphorylation | ILPKSDWTSLARSQA EEEHHHHHHHHHHHC | 21454597 | ||
| 750 | Phosphorylation | ARSQAGFTRRSSGSA HHHHCCCCCCCCCCC | 24719451 | ||
| 753 | Phosphorylation | QAGFTRRSSGSADST HCCCCCCCCCCCCCC | 30635358 | ||
| 754 | Phosphorylation | AGFTRRSSGSADSTS CCCCCCCCCCCCCCC | 30635358 | ||
| 756 | Phosphorylation | FTRRSSGSADSTSWH CCCCCCCCCCCCCEE | 30635358 | ||
| 759 | Phosphorylation | RSSGSADSTSWHRSD CCCCCCCCCCEEHHH | 30635358 | ||
| 760 | Phosphorylation | SSGSADSTSWHRSDV CCCCCCCCCEEHHHH | 30635358 | ||
| 761 | Phosphorylation | SGSADSTSWHRSDVL CCCCCCCCEEHHHHH | - | ||
| 803 | Phosphorylation | ASQNSSLTAMHGPSG CCCCCCCEEECCCCC | - | ||
| 896 | Phosphorylation | IADKETPSPEVSVSW HCCCCCCCCCCCCEE | - | ||
| 910 | Phosphorylation | WRNPICDSPSDSLLA ECCCCCCCCCCCHHH | 25168779 | ||
| 912 | Phosphorylation | NPICDSPSDSLLAEN CCCCCCCCCCHHHCC | 25168779 | ||
| 914 | Phosphorylation | ICDSPSDSLLAENFS CCCCCCCCHHHCCCC | 29472430 | ||
| 921 | Phosphorylation | SLLAENFSCSTDRKL CHHHCCCCCCCCCCC | 29472430 | ||
| 952 | Phosphorylation | LQQKPTKSPQTTQSG HHHCCCCCCCCCCCC | 29550500 | ||
| 1189 | Acetylation | QSEISRKKCGKRLWE HHHHHHHHHHHHHHH | - | ||
| 1209 | Phosphorylation | ASEEWAESEGDDSCG HHHHHHHHCCCCCCC | 26745281 | ||
| 1369 | Phosphorylation | TAFRYQISAVTSEVI HHHHHHHHHCCHHHH | 27600695 | ||
| 1473 | Phosphorylation | QSANFDKSRLRNRPV CCCCCCHHHHHCCCC | 28059163 | ||
| 1553 | Phosphorylation | NEVPQPASGEGTNIK CCCCCCCCCCCCCCC | - | ||
| 1573 | Phosphorylation | AQPIMAGTDRSTPTN CCCCCCCCCCCCCCC | 26643407 | ||
| 1576 | Phosphorylation | IMAGTDRSTPTNCSP CCCCCCCCCCCCCCH | 26745281 | ||
| 1577 | Phosphorylation | MAGTDRSTPTNCSPD CCCCCCCCCCCCCHH | 26745281 | ||
| 1579 | Phosphorylation | GTDRSTPTNCSPDTL CCCCCCCCCCCHHHH | 26643407 | ||
| 1582 | Phosphorylation | RSTPTNCSPDTLSKI CCCCCCCCHHHHHHH | 26745281 | ||
| 1585 | Phosphorylation | PTNCSPDTLSKIRQE CCCCCHHHHHHHHHH | 28066266 | ||
| 1587 | Phosphorylation | NCSPDTLSKIRQEVG CCCHHHHHHHHHHHC | 28066266 | ||
| 1607 | Phosphorylation | LLPPLIATPPRSSQT CCCCCCCCCCCCCCC | 25159016 | ||
| 1611 | Phosphorylation | LIATPPRSSQTLSPL CCCCCCCCCCCCCCC | 26643407 | ||
| 1612 | Phosphorylation | IATPPRSSQTLSPLV CCCCCCCCCCCCCCC | 26643407 | ||
| 1614 | Phosphorylation | TPPRSSQTLSPLVPN CCCCCCCCCCCCCCC | 26643407 | ||
| 1616 | Phosphorylation | PRSSQTLSPLVPNSG CCCCCCCCCCCCCCC | 26643407 | ||
| 1628 | Phosphorylation | NSGPSSRSSPAGHVS CCCCCCCCCCCCCCC | 25293948 | ||
| 1629 | Phosphorylation | SGPSSRSSPAGHVSP CCCCCCCCCCCCCCC | 25293948 | ||
| 1635 | Phosphorylation | SSPAGHVSPLCEVPG CCCCCCCCCCCCCCC | 25293948 | ||
| 1647 | Phosphorylation | VPGPPVLSPWPEELQ CCCCCCCCCCCHHHH | 25293948 | ||
| 1657 | Phosphorylation | PEELQQASPLDPSPS CHHHHHCCCCCCCCC | 25293948 | ||
| 1662 | Phosphorylation | QASPLDPSPSPSTAA HCCCCCCCCCHHHHH | 25293948 | ||
| 1664 | Phosphorylation | SPLDPSPSPSTAAAS CCCCCCCCHHHHHHC | 25293948 | ||
| 1666 | Phosphorylation | LDPSPSPSTAAASGR CCCCCCHHHHHHCCC | 25293948 | ||
| 1667 | Phosphorylation | DPSPSPSTAAASGRI CCCCCHHHHHHCCCC | 25293948 | ||
| 1671 | Phosphorylation | SPSTAAASGRIVSSP CHHHHHHCCCCCCCC | 25293948 | ||
| 1676 | Phosphorylation | AASGRIVSSPLQFCA HHCCCCCCCCCHHHC | 26239621 | ||
| 1677 | Phosphorylation | ASGRIVSSPLQFCAA HCCCCCCCCCHHHCC | 26824392 | ||
| 1685 | Phosphorylation | PLQFCAATPKHALPV CCHHHCCCCCCCCCC | 28066266 | ||
| 1742 | Phosphorylation | LKGNMQLSRGSTVDG HHCCEEECCCCCCCC | 26160508 | ||
| 1745 | Phosphorylation | NMQLSRGSTVDGKVL CEEECCCCCCCCEEC | 26160508 | ||
| 1746 | Phosphorylation | MQLSRGSTVDGKVLP EEECCCCCCCCEECC | 26160508 | ||
| 1757 | Phosphorylation | KVLPGRVSALLGLKA EECCHHHHHHHCCEE | 26824392 | ||
| 1820 | Phosphorylation | RLRLDNKSPEPDTRE HHCCCCCCCCCCCCC | 26824392 | ||
| 1825 | Phosphorylation | NKSPEPDTREVTGEG CCCCCCCCCCCCCCC | 25777480 | ||
| 1841 | Phosphorylation | PEDPQGGSPLAEVVP CCCCCCCCCCCEECC | 25293948 | ||
| 1863 | Phosphorylation | VPVCSAASLLRVNPR CCCCCHHHHHCCCHH | 27149854 | ||
| 2205 | Phosphorylation | KILEAWRTQTSNAIP HHHHHHHHCCCCCCC | - | ||
| 2207 | Phosphorylation | LEAWRTQTSNAIPSA HHHHHHCCCCCCCHH | - | ||
| 2208 | Phosphorylation | EAWRTQTSNAIPSAI HHHHHCCCCCCCHHH | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ICE1_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ICE1_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ICE1_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of ICE1_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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