dbPTM

LAT3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	LAT3_MOUSE
UniProt AC	Q8BSM7
Protein Name	Large neutral amino acids transporter small subunit 3
Gene Name	Slc43a1 {ECO:0000312\|MGI:MGI:1931352}
Organism	Mus musculus (Mouse).
Sequence Length	564
Subcellular Localization	Membrane Multi-pass membrane protein .
Protein Description	Sodium-independent, high affinity transport of large neutral amino acids. Has narrower substrate selectivity compared to SLC7A5 and SLC7A8 and mainly transports branched-chain amino acids and phenylalanine (By similarity)..
Protein Sequence	MAPTLKQAYRRRWWMACTAVVENLFFSAVLLGWASLLIMLKKEGFYSSLCPAENRTNTTQDEQHQWTSCDQQEKMLNLGFTIGSFLLSATTLPLGILMDRFGPRPLRLVGSACFAASCTLMALASRDTEVLSPLIFLALSLNGFAGICLTFTSLTLPNMFGNLRSTFMALMIGSYASSAITFPGIKLIYDAGVPFTVIMFTWSGLACLIFLNCALNWPAEAFPAPEEVDYTKKIKLIGLALDHKVTGDRFYTHVTIVGQRLSQKSPSLEEGADAFISSPDIPGTSEETPEKSVPFRKSLCSPIFLWSLVTMGMTQLRVIFYMGAMNKILEFIVTGGKERETNEQRQKVEETVEFYSSIFGVMQLLCLLTCPLIGYIMDWRIKDCVDAPTEGTLNENASFGDARDGASTKFTRPRYRKVQKLTNAINAFTLTNILLVGFGIACLIKNLHLQLLAFVLHTIVRGFFHSACGGLYAAVFPSNHFGTLTGLQSLISAVFALLQQLLFMAMVGPLHGDPFWVNLGLLLLSFLGFLLPSYLYYYRSRLQREYATNLVDPQKVLNTSKVAT

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Ubiquitination	--MAPTLKQAYRRRW --CCCHHHHHHHHHH	35.05	22790023
54	N-linked_Glycosylation	SSLCPAENRTNTTQD HHCCCCCCCCCCCHH	59.17	-
57	N-linked_Glycosylation	CPAENRTNTTQDEQH CCCCCCCCCCHHHHH	37.58	19349973
81	Phosphorylation	KMLNLGFTIGSFLLS HHHHHCCHHHHHHHH	23.72	28609623
84	Phosphorylation	NLGFTIGSFLLSATT HHCCHHHHHHHHHCC	14.63	28609623
88	Phosphorylation	TIGSFLLSATTLPLG HHHHHHHHHCCCCCH	26.22	28609623
90	Phosphorylation	GSFLLSATTLPLGIL HHHHHHHCCCCCHHH	26.03	28609623
91	Phosphorylation	SFLLSATTLPLGILM HHHHHHCCCCCHHHH	26.54	28609623
251	Phosphorylation	KVTGDRFYTHVTIVG CCCCCCCEEEEEEEC	9.24	29514104
262	Phosphorylation	TIVGQRLSQKSPSLE EEECHHHCCCCCCHH	37.44	26060331
265	Phosphorylation	GQRLSQKSPSLEEGA CHHHCCCCCCHHHCC	16.45	25521595
267	Phosphorylation	RLSQKSPSLEEGADA HHCCCCCCHHHCCCC	56.34	25521595
277	Phosphorylation	EGADAFISSPDIPGT HCCCCCCCCCCCCCC	29.39	23737553
278	Phosphorylation	GADAFISSPDIPGTS CCCCCCCCCCCCCCC	23.06	23737553
284	Phosphorylation	SSPDIPGTSEETPEK CCCCCCCCCCCCCCC	27.84	23140645
285	Phosphorylation	SPDIPGTSEETPEKS CCCCCCCCCCCCCCC	39.07	20469934
288	Phosphorylation	IPGTSEETPEKSVPF CCCCCCCCCCCCCCC	32.47	20469934
392	Phosphorylation	VDAPTEGTLNENASF CCCCCCCCCCCCCCC	21.85	25521595
396	N-linked_Glycosylation	TEGTLNENASFGDAR CCCCCCCCCCCCCCC	39.55	-
398	Phosphorylation	GTLNENASFGDARDG CCCCCCCCCCCCCCC	41.15	25521595
408	Phosphorylation	DARDGASTKFTRPRY CCCCCCCCCCCCHHH	29.64	-
422	Phosphorylation	YRKVQKLTNAINAFT HHHHHHHHHHHHHHH	29.64	-
429	Phosphorylation	TNAINAFTLTNILLV HHHHHHHHHHHHHHH	30.20	-
555	Ubiquitination	TNLVDPQKVLNTSKV HCCCCHHHHHCCCCC	54.82	22790023
558	N-linked_Glycosylation	VDPQKVLNTSKVAT- CCHHHHHCCCCCCC-	45.34	-
560	Phosphorylation	PQKVLNTSKVAT--- HHHHHCCCCCCC---	24.86	30482847

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of LAT3_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of LAT3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of LAT3_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of LAT3_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of LAT3_MOUSE

Related Literatures of Post-Translational Modification

N-linked Glycosylation
Reference	PubMed
"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."; Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M.,Schiess R., Aebersold R., Watts J.D.; Nat. Biotechnol. 27:378-386(2009). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-57, AND MASS SPECTROMETRY.	19349973 [Abstract]
Phosphorylation
Reference	PubMed
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-265, AND MASSSPECTROMETRY.	17242355 [Abstract]