NUP50_MOUSE - dbPTM
NUP50_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NUP50_MOUSE
UniProt AC Q9JIH2
Protein Name Nuclear pore complex protein Nup50
Gene Name Nup50
Organism Mus musculus (Mouse).
Sequence Length 466
Subcellular Localization Nucleus, nuclear pore complex. Nucleus membrane
Peripheral membrane protein
Nucleoplasmic side . Localizes to the nucleoplasmic fibrils of the nuclear pore complex. Dissociates from the NPC structure early during prophase of mitosis. Associates w
Protein Description Component of the nuclear pore complex that has a direct role in nuclear protein import. [PubMed: 10811608 Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta-cargo complex and importin recycling]
Protein Sequence MAKRVAEKELTDRNWDEEDEVEEMGTFSVASEEVMKNRAVKKAKRRNVGFESDSGGAFKGFKGLVVPSGGGGFSGFGGSGGKPLEGLTNGNSTDNATPFSNVKTAAEPKAAFGSFAVNGPTTLVDKKISSPKCNNSNQPPSSGPASSTACPGNAYHKQLAGLNCSVRDWIVKHVNTNPLCDLTPIFKDYERYLATIEKQLENGGGSSSESQTDRATAGMEPPSLFGSTKLQQESPFSFHGNKAEDTSEKVEFTAEKKSDAAQGATSASFSFGKKIESSALGSLSSGSLTGFSFSAGSSSLFGKDAAQSKAASSLFSAKASESPAGGGSSECRDGEEEENDEPPKVVVTEVKEEDAFYSKKCKLFYKKDNEFKEKGVGTLHLKPTATQKTQLLVRADTNLGNILLNVLIAPNMPCTRTGKNNVLIVCVPNPPLDEKQPTLPATMLIRVKTSEDADELHKILLEKKDA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
8AcetylationMAKRVAEKELTDRNW
CCCCHHHHHHCCCCC		48.5723806337
52PhosphorylationRRNVGFESDSGGAFK
HCCCCCCCCCCCCCC		34.5126525534
54PhosphorylationNVGFESDSGGAFKGF
CCCCCCCCCCCCCCC		48.7026643407
59UbiquitinationSDSGGAFKGFKGLVV
CCCCCCCCCCCEEEE		64.0022790023
59AcetylationSDSGGAFKGFKGLVV
CCCCCCCCCCCEEEE		64.0022826441
82AcetylationGFGGSGGKPLEGLTN
CCCCCCCCCCCCCCC		50.37-
104PhosphorylationTPFSNVKTAAEPKAA
CCCCCCCCCCCCCHH		27.1518779572
114PhosphorylationEPKAAFGSFAVNGPT
CCCHHHCCCEECCCC		11.9917203969
121PhosphorylationSFAVNGPTTLVDKKI
CCEECCCCEEEECCC		33.8717203969
122PhosphorylationFAVNGPTTLVDKKIS
CEECCCCEEEECCCC		28.1117203969
126AcetylationGPTTLVDKKISSPKC
CCCEEEECCCCCCCC		44.5223806337
129PhosphorylationTLVDKKISSPKCNNS
EEEECCCCCCCCCCC		49.8526160508
130PhosphorylationLVDKKISSPKCNNSN
EEECCCCCCCCCCCC		31.6726160508
136PhosphorylationSSPKCNNSNQPPSSG
CCCCCCCCCCCCCCC		23.8926160508
172AcetylationSVRDWIVKHVNTNPL
CHHHHHHHHCCCCCC		32.4722826441
208PhosphorylationENGGGSSSESQTDRA
HCCCCCCCHHHHHHH		42.86-
216PhosphorylationESQTDRATAGMEPPS
HHHHHHHCCCCCCCH		25.3329514104
229UbiquitinationPSLFGSTKLQQESPF
CHHHCCCCCEECCCC		46.1022790023
234PhosphorylationSTKLQQESPFSFHGN
CCCCEECCCCCCCCC		27.2327087446
237PhosphorylationLQQESPFSFHGNKAE
CEECCCCCCCCCCCC		21.5125159016
246PhosphorylationHGNKAEDTSEKVEFT
CCCCCCCCCCCEEEE		30.23-
257AcetylationVEFTAEKKSDAAQGA
EEEEEECCCHHHCCC		45.1022826441
265PhosphorylationSDAAQGATSASFSFG
CHHHCCCCEEEEECC		31.4825338131
268PhosphorylationAQGATSASFSFGKKI
HCCCCEEEEECCCCC		22.61-
273AcetylationSASFSFGKKIESSAL
EEEEECCCCCCCCCC		48.8722826441
273UbiquitinationSASFSFGKKIESSAL
EEEEECCCCCCCCCC		48.8722790023
294PhosphorylationSLTGFSFSAGSSSLF
CCCCEEEECCCHHHC		30.44-
312PhosphorylationAAQSKAASSLFSAKA
HHHHHHHHHHHHCCC		32.2227600695
313PhosphorylationAQSKAASSLFSAKAS
HHHHHHHHHHHCCCC		28.8021183079
320PhosphorylationSLFSAKASESPAGGG
HHHHCCCCCCCCCCC		37.5928066266
322PhosphorylationFSAKASESPAGGGSS
HHCCCCCCCCCCCCC		19.9725263469
328PhosphorylationESPAGGGSSECRDGE
CCCCCCCCCCCCCCC		26.6626745281
329PhosphorylationSPAGGGSSECRDGEE
CCCCCCCCCCCCCCC		43.9526745281
382UbiquitinationGVGTLHLKPTATQKT
CCEEEEECCCCCCCE		29.5827667366
397PhosphorylationQLLVRADTNLGNILL
EEEEECCCCHHHHHH		31.2125890499
417PhosphorylationPNMPCTRTGKNNVLI
CCCCCCCCCCCCEEE		34.0625890499
448AcetylationATMLIRVKTSEDADE
EEEEEEEECCCCHHH		36.1623806337
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NUP50_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NUP50_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NUP50_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CDN1B_MOUSECdkn1bphysical
10811608
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NUP50_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Protein phosphorylation and expression profiling by Yin-yangmultidimensional liquid chromatography (Yin-yang MDLC) massspectrometry.";
Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R.;
J. Proteome Res. 6:250-262(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-114, AND MASSSPECTROMETRY.

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