PLBL1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PLBL1_MOUSE
• UniProt AC: Q8VCI0
• Protein Name: Phospholipase B-like 1
• Gene Name: Plbd1
• Organism: Mus musculus (Mouse).
• Sequence Length: 550
• Subcellular Localization: Lysosome.
• Protein Description: Exhibits weak phospholipase activity, acting on various phospholipids, including phosphatidylcholine, phosphatidylinositol, phosphatidylethanolamine and lysophospholipids. However, in view of the small size of the putative binding pocket, it has been proposed that it may act rather as an amidase or a peptidase (By similarity)..
• Protein Sequence: MCHRSPGRSLRPPSPLLLLLPLLLQPPWAAGAASQSDPTGVHCATAYWSPESKKVEIKTVLDKNGDAYGYYNDSIKTTGWGILEIRAGYGSQVLSNEIIMFLAGYLEGYLTALHMYDHFTNLYPQLIKNPSIVKKVQDFMEKQEMWTRQNIKAQKDDPFWRHTGYVVTQLDGLYLGAQKRASEEKIKPMTMFQIQFLNAVGDLLDLIPSLSPTKSSSMMKFKIWEMGHCSALIKVLPGFENIYFAHSSWYTYAAMLRIYKHWDFNIKDKYTLSKRLSFSSYPGFLESLDDFYILSSGLILLQTTNSVYNKTLLKQVVPKTLLAWQRVRVANMMAEGGKEWAQIFSKHNSGTYNNQYMVLDLKKVTINRSLDKGTLYIVEQIPTYVEYSDQTNVLRKGYWASYNIPFHKTIYNWSGYPLLVHKLGLDYSYDLAPRAKIFRRDQGNVTDMASMKYIMRYNNYKEDPYSKGDPCSTICCREDLNGASPSPGGCYDTKVADIFLASQYKAYAISGPTVQDGLPPFNWNRFNETLHRGMPEVFDFNFVTMKPILS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
72	N-linked_Glycosylation	GDAYGYYNDSIKTTG CCCCCEECCCCCCCC	28.24	16170054
309	N-linked_Glycosylation	QTTNSVYNKTLLKQV ECCCCCCCHHHHHHH	28.78	-
367	N-linked_Glycosylation	DLKKVTINRSLDKGT EEEEEEEECCCCCCE	20.37	-
412	N-linked_Glycosylation	PFHKTIYNWSGYPLL CCCCEECCCCCCCEE	23.68	-
457	Phosphorylation	SMKYIMRYNNYKEDP HHHHHHHHCCCCCCC	7.15	22817900
527	N-linked_Glycosylation	PFNWNRFNETLHRGM CCCHHHHHHHHHCCC	37.80	-
529	Phosphorylation	NWNRFNETLHRGMPE CHHHHHHHHHCCCCC	29.03	30635358
544	Phosphorylation	VFDFNFVTMKPILS- EECCEEEEECCCCC-	18.49	30635358
550	Phosphorylation	VTMKPILS------- EEECCCCC-------	38.61	30635358

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PLBL1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PLBL1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PLBL1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PLBL1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"High throughput quantitative glycomics and glycoform-focusedproteomics of murine dermis and epidermis.";
Uematsu R., Furukawa J., Nakagawa H., Shinohara Y., Deguchi K.,Monde K., Nishimura S.;
Mol. Cell. Proteomics 4:1977-1989(2005).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-72, AND MASS SPECTROMETRY.
PubMed: 16170054