P5CR3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: P5CR3_MOUSE
• UniProt AC: Q9DCC4
• Protein Name: Pyrroline-5-carboxylate reductase 3 {ECO:0000250|UniProtKB:Q53H96}
• Gene Name: Pycr3 {ECO:0000250|UniProtKB:Q53H96}
• Organism: Mus musculus (Mouse).
• Sequence Length: 274
• Subcellular Localization: Cytoplasm .
• Protein Description: Enzyme that catalyzes the last step in proline biosynthesis. Proline is synthesized from either glutamate or ornithine; both are converted to pyrroline-5-carboxylate (P5C), and then to proline via pyrroline-5-carboxylate reductases (PYCRs). PYCRL is exclusively linked to the conversion of ornithine to proline..
• Protein Sequence: MAATMSEPRRVGFVGAGRMAEAIARGLIQAGKVEAKQVLASAPTDNNLCHFRALGCQTTHSNHEVLQNCPLVIFATKPQVLPTVLAEVAPIVTTEHIIVSVAAGISLSTMEGLLPPNTRVLRVSPNLPCVVQEGAMVMARGHHAGNDDAELLQNLLEACGQCIEVPESYVDIHTGLSGSGVAFVCTFSEALAEGAIKMGMPSGLAHRIAAQTLLGTAKMLQQEGKHPAQLRTDVLTPAGTTIHGLHALERGGFRAATMSAVEAATCRAKELSKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAATMSEPR ------CCCCCCCCC	16.19	-
4	Phosphorylation	----MAATMSEPRRV ----CCCCCCCCCCC	16.22	25619855
6	Phosphorylation	--MAATMSEPRRVGF --CCCCCCCCCCCCC	39.84	25619855
49	S-nitrosocysteine	APTDNNLCHFRALGC CCCCCCCCCEEECCC	2.87	-
49	Glutathionylation	APTDNNLCHFRALGC CCCCCCCCCEEECCC	2.87	24333276
49	S-nitrosylation	APTDNNLCHFRALGC CCCCCCCCCEEECCC	2.87	21278135
49	S-palmitoylation	APTDNNLCHFRALGC CCCCCCCCCEEECCC	2.87	28526873
109	Ubiquitination	AAGISLSTMEGLLPP HHCCCHHHHCCCCCC	25.24	27667366
129	S-palmitoylation	RVSPNLPCVVQEGAM EECCCCCEEEECCCE	5.44	28526873
218	Ubiquitination	QTLLGTAKMLQQEGK HHHHHHHHHHHHCCC	39.73	22790023
236	Phosphorylation	QLRTDVLTPAGTTIH HHCCEEECCCCCCHH	15.79	-
266	Glutathionylation	SAVEAATCRAKELSK HHHHHHHHHHHHHHC	3.23	24333276
266	S-palmitoylation	SAVEAATCRAKELSK HHHHHHHHHHHHHHC	3.23	28526873

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of P5CR3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of P5CR3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of P5CR3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of P5CR3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.